Methods for recommending a program to improve or maintain pro-inflammatory immune health

• US 20070150204A1
• Filed: 12/27/2005
• Published: 06/28/2007
• Est. Priority Date: 12/27/2005
• Status: Abandoned Application

• Current Assignee: Johnson & Johnson Consumer Companies Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Consumer Companies Incorporated (Johnson & Johnson)
• Inventors: Wiegand, Benjamin, Luedtke, Kathryn
• Application Number:
  US11/318,869
• Publication Number:
  US 20070150204A1
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: G01N 33/5091 for testing the pathological state of an organism
• CPC Class Codes: G01N 33/6863 Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
• CPC Class Codes: G01N 33/6866 Interferon
• CPC Class Codes: G01N 33/6869 Interleukin
• CPC Class Codes: G16B 20/00 ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 20/30 relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: G16H 20/60 relating to nutrition control, e.g. diets
• CPC Class Codes: G16H 20/70 relating to mental therapies, e.g. psychological therapy or autogenous training
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

The invention relates to a method of assessing the pro-inflammatory immune health of a healthy individual comprising: (a) establishing a benchmark pro-inflammatory protein value set, wherein the pro-inflammatory protein value is determined by a calculation made using levels of pro-inflammatory protein measured in samples of non-blood body fluid collected from healthy individuals at one or more time points in a 24 hour period; (b) determining an optimal pro-inflammatory protein value range from the benchmark pro-inflammatory protein value set established in (a) by using descriptive statistic methodology; (c ) establishing a pro-inflammatory protein value for said individual to be assessed, wherein said value is determined by the same calculation as set forth in (a); and (d) comparing the value established in step (c) to the optimal pro-inflammatory protein value range determined in step (b), wherein a pro-inflammatory protein value for said individual that is within the optimal pro-inflammatory protein value range is indicative of good pro-inflammatory immune health and wherein a pro-inflammatory protein value that is outside the optimal pro-inflammatory protein value range is indicative of inferior pro-inflammatory immune health.

Claims

1. A method for recommending a program to improve or maintain pro-inflammatory immune health of a healthy individual comprising:

(a) establishing a benchmark pro-inflammatory protein value set, wherein the pro-inflammatory protein value is determined by a calculation made using levels of pro-inflammatory protein measured in samples of non-blood body fluid collected from healthy individuals at one or more time points in a 24 hour period;

(b) determining an optimal pro-inflammatory protein value range from the benchmark pro-inflammatory protein value set established in (a) by using descriptive statistic methodology;

(c) establishing a pro-inflammatory protein value for said individual to be assessed, wherein said value is determined by the same calculation as set forth in (a)b; and

comparing the value established in step (c) to the optimal pro-inflammatory protein value range determined in step (b), wherein a pro-inflammatory protein value for said individual that is within the optimal pro-inflammatory protein value range is indicative of good pro-inflammatory immune health and wherein a pro-inflammatory protein value that is outside the optimal pro-inflammatory protein value range is indicative of inferior pro-inflammatory immune health;

wherein when the pro-inflammatory protein value for said individual is within the optimal pro-inflammatory protein value range the recommended program comprises instructions for the individual to continue practicing his or her current lifestyle factors;

(wherein when the pro-inflammatory protein value for said individual is outside the optimal pro-inflammatory protein value range, the recommended program comprises instructions to change current lifestyle factors.

2. The method according to claim 1, wherein the recommendation to change current lifestyle factors includes at least one of the following recommendations:

i. improve sleep;

ii. stop smoking;

iii. reduce stress;

iv. lose weight;

v. reduce alcohol usage;

vi. reduce caffeine consumption.

3. The method according to claim 1, wherein said recommendation to change lifestyle factors includes at least one of the following:

a. a recommendation to seek psychological, emotion and/or social counseling,

b. a recommendation to start an exercise program

c. a recommendation to practice behavioral modification techniques,

d. a recommendation to practice relaxation techniques and/or breathing techniques,

e. a recommendation to improve sleep patterns;

f. a recommendation to increase sleep,

g. a recommendation to reduce or cease smoking,

h. a recommendation to loose weight; and

i. a recommendation to administer herbal supplements, vitamins or special food, and/or over the counter or prescription medications;

j. a recommendation to start an in-person coaching program;

k. a recommendation to start an online coaching program;

l. a recommendation to practice a sensory regimen.

4. The method according to claim 1, wherein the non-blood body fluid is saliva, nasal secretions, tears, breath, or combinations thereof.

5. The method according to claim 3, wherein the non-blood body fluid is saliva.

6. The method according to claim 4, wherein the level of pro-inflammatory protein in saliva is measured using an ELISA or RIA technique.

7. The method according to claim 1, wherein the pro-inflammatory protein is selected from a c-reactive protein, cytokines, and mixtures thereof.

8. The method according to claim 1, wherein said cytokine is selected from interleukin 1α

, interleukin-1β

, interleukin-2, interleukin-6, interferon-alpha, interferon-gamma, tumor necrosis factor-α

, growth factors, omcogenes and mixtures thereof.

9. The method according to claim 2 wherein the cytokine is IL-6.

10. The method according to claim 1, wherein the benchmark pro-inflammatory protein value set is established by measuring the pro-inflammatory protein value of at greater than 25 healthy individuals.

11. The method according to claim 1, wherein said pro-inflammatory protein is measured at least at one of the following time points:

(1) at or about waking;

(2) about 30 minutes post waking;

(4) about 60 minutes post waking;

(5) about 10 hours post waking; and

(6) about 16 hours post waking.

12. The method according to claim 1 wherein the pro-inflammatory protein value comprises the level of the pro-inflammatory protein in the saliva of the individual as measured at the time of waking.

13. The method according to claim 1 wherein the pro-inflammatory protein value comprises the level of the pro-inflammatory protein in the saliva of the individual as measured about 16 hours post waking.

14. The method according to claim 1, wherein said recommendation is delivered via a personalized report.

15. The method according to claim 14, wherein personalized report includes one or more of the following:

age;

name;

gender;

product preferences, family composition, address, coupons, a summary of lifestyle factors.

16. The method according to claim 15, wherein said lifestyle factors are selected from at least one of the following :

(1) the quantity and/or frequency of smoking or chewing any form of tobacco;

(2) sleep quantity and quality ;

(3) alcohol consumption;

(4) caffeine consumption; and

(5) body weight.

17. A method for recommending a program to improve or maintain pro-inflammatory immune health of a healthy individual comprising:

(a) establishing a benchmark pro-inflammatory protein value set of the value of pro-inflammatory protein at least at two time points in a 24 hour period in non-blood body fluid of healthy, individuals;

(b) determining an optimal pro-inflammatory protein value range from the benchmark pro-inflammatory protein value set established in (a) by using descriptive statistic methodology;

(c) establishing a pro-inflammatory protein value for said individual by measuring the value of the pro-inflammatory protein in non-blood body fluid of said individual wherein said value is determined by the same calculation as set forth in (a); and

(d) comparing the value in step (c) to the value in step (b), wherein a pro-inflammatory protein value for said individual that is within the optimal pro-inflammatory protein value range is indicative of good pro-inflammatory immune health and wherein a pro-inflammatory protein value range outside the optimal pro-inflammatory protein value range is indicative of inferior pro-inflammatory immune health

(e) wherein when the pro-inflammatory protein value for said individual is within the optimal pro-inflammatory protein value range the recommended program comprises instructions to continue practicing his or her current lifestyle factors;

(f) wherein when the pro-inflammatory protein value for said individual is outside the optimal pro-inflammatory protein value range, the recommended program comprises instructions to change current lifestyle factors.

18. The method according to claim 17, wherein said pro-inflammatory protein value is determined by measuring the level of pro-inflammatory protein at least at two of the following time points:

(1) at or about waking;

(2) about 30 minutes post waking;

(3) about 60 minutes post waking;

(4) about 6 hours post waking;

(5) about 10 hours post waking;

(6) about 16 hours post waking.

19. The method according to claim 18, wherein the level of pro-inflammatory protein is measured at least at two of the following time points:

(1) at or about waking;

(2) about 30 minutes post waking;

(3) about 6 hours post waking;

(4) about 16 hours post waking.

20. The method according to claim 19, wherein the level of pro-inflammatory protein is measured at (1) at or about waking;

and (2) about 30 minutes post waking.

21. The method according to claim 19, wherein the pro-inflammatory protein is measured at (1) about 6 hours post waking;

and (2) about 16 hours post waking.

22. The method according to claim 17, wherein the pro-inflammatory protein value is determined by calculating the area under the curve defined by the levels of the pro-inflammatory protein in non-blood body fluid of the individual as measured at or about waking, about 30 minutes post waking, about 10 hours post waking, and about 16 hours post waking versus the respective times.

23. The method according to claim 17, wherein the pro-inflammatory protein value is determined by calculating the slope over time of the levels of the pro-inflammatory protein in the saliva of the individual as measured at or about waking and about 30 minutes post waking.

24. The method according to claim 17, wherein the pro-inflammatory protein value is determined by calculating the slope over time of the levels of the pro-inflammatory protein in the saliva of the individual as measured at about 10 hours post waking and about 16 hours post waking.

25. The method according to claim 17, wherein the pro-inflammatory protein value is determined by calculating the ratio of the level of pro-inflammatory protein in the saliva as measured at or about waking and the level of pro-inflammatory protein in the saliva as measured at 16 hours post waking.