Subcutaneous Glucose Electrode
First Claim
1. An analyte measurement system, comprising:
- at least one sensor introducer;
a first electrochemical sensor having at least one electrode with analyte response enzyme thereon, the first electrochemical sensor coupleable to the at least one sensor introducer for positioning at least a portion of the first sensor in the body of a user;
a second electrochemical sensor having at least one electrode with analyte response enzyme thereon, the second electrochemical sensor coupleable to the at least one sensor introducer for positioning at least a portion of the second sensor in the body of a user; and
a device to compare signals obtained from the first and second sensors.
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Accused Products
Abstract
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
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Citations
18 Claims
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1. An analyte measurement system, comprising:
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at least one sensor introducer;
a first electrochemical sensor having at least one electrode with analyte response enzyme thereon, the first electrochemical sensor coupleable to the at least one sensor introducer for positioning at least a portion of the first sensor in the body of a user;
a second electrochemical sensor having at least one electrode with analyte response enzyme thereon, the second electrochemical sensor coupleable to the at least one sensor introducer for positioning at least a portion of the second sensor in the body of a user; and
a device to compare signals obtained from the first and second sensors. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of analyte measurement, comprising:
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positioning at least a portion of at least one electrode of a first electrochemical sensor having analyte response enzyme thereon, in fluid contact with body fluid;
positioning at least a portion of at least one electrode of a second electrochemical sensor having analyte response enzyme thereon, in fluid contact with body fluid; and
comparing signals obtained from the first and second sensors. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification