Portable NMR device and method for making and using the same

• US 20070152670A1
• Filed: 12/29/2005
• Published: 07/05/2007
• Est. Priority Date: 12/29/2005
• Status: Active Grant

• Current Assignee: Intel Corporation
• Original Assignee: Intel Corporation
• Inventors: Park, Chang-Min, Ramanathan, Shriram, Morrow, Patrick, Cadien, Kenneth
• Granted Patent: US 7,345,479 B2
• Time in Patent Office: Days
• US Class Current: 324/321
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: G01N 24/08 by using nuclear magnetic resonance G01N24/12 takes precedence
• CPC Class Codes: G01R 33/302 Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips

Abstract

An embodiment of the invention relates to a portable or handheld device for performing NMR analysis. The device comprises a console and a strip which can be placed into the console through a slot or other means. The strip comprises a sample holding place and a microcoil for generating an excitation magnetic field across a sample in the sample holding space. A permanent magnet is provided either by the console or the strip and generates a static magnetic field which, together with the excitation field, creates NMR within the sample. Other embodiments of the invention also encompass method of performing NMR analysis using the portable device and method of making such devices.

Claims

1. A portable device comprising:

a console;

a strip, the strip comprising a space for holding a liquid sample and a microcoil capable of generating an excitation magnetic field across at least a portion of the space; and

a magnet capable of generating a static magnetic field across at least a portion of the space;

wherein the strip is capable of being placed within the console and wherein the static magnetic field and the excitation magnetic field are capable of creating Nuclear Magnetic Resonance (NMR) within a liquid sample contained in the space; and

wherein the microcoil is capable of detecting signals from the NMR.

2. The portable device of claim 1, wherein the console has a dimension of from about 1.0 cm to about 50 cm.

3. The portable device of claim 1, wherein the device is powered by a battery.

4. The portable device of claim 1, wherein the console comprises an opening through which the strip is placed within the console.

5. The portable device of claim 4, wherein the opening is a slot through which the strip is inserted into the console.

6. The portable device of claim 1, wherein the console comprises circuitry capable of detecting, processing, or analyzing the signals from the NMR.

7. The portable device of claim 1, wherein the console comprises an integrated circuit or a MEMS.

8. The portable device of claim 1, wherein the strip comprises silicon, glass, a polymeric material, metal, or a combination thereof.

9. The portable device of claim 1, wherein the strip comprises an integrated circuit, a MEMS device, a microarray, a macroarray, a multi-well plate, a microfluidic device, or a combination thereof.

10. The portable device of claim 1, wherein the strip comprises circuitry capable of amplifying or processing the NMR signals detected by the microcoil.

11. The portable device of claim 1, wherein the space for holding a liquid sample comprises a reservoir, a microchannel, an opening, a surface, or a combination thereof.

12. The portable device of claim 11, wherein the space for holding a liquid sample is a microchannel, the microchannel having two or more inlets, at least one outlet, and at least one mixing section where liquid samples introduced from the two or more inlets can be mixed.

13. The portable device of claim 1, wherein the space for holding a liquid sample has a volume of from about 1.0 nL to about 1.0 mL.

14. The portable device of claim 13, wherein the space for holding a liquid sample has a volume of from about 10 nL to about 10 uL.

15. The portable device of claim 1, wherein the microcoil comprises copper, aluminum, gold, silver, or a mixture thereof.

16. The portable device of claim 1, wherein the microcoil is placed near or adjacent to the space for holding a liquid sample.

17. The portable device of claim 1, wherein the microcoil is a Solenoid type coil.

18. The portable device of claim 1, wherein the microcoil is a planar spiral coil.

19. The portable device of claim 18, wherein the planar spiral microcoil comprises an inner-area dimension of from about 10 μ

m to 10 mm, about 1 to 100 windings, and a winding separation of about 1 μ

m to 500 μ

m.

20. The portable device of claim 19, wherein the planar spiral microcoil comprises an inner-area dimension of from about 100 μ

m to 1.0 mm, about 1 to 30 windings, and a winding separation of about 10 μ

m to 100 μ

m.

21. The portable device of claim 1, wherein the microcoil has a cross-section dimension of from about 0.01 μ

m to about 100 μ

m.

22. The portable device of claim 1, wherein the magnet is located on the console.

23. The portable device of claim 1, wherein the magnet is located on the strip.

24. The portable device of claim 1, wherein the magnet comprises a permanent magnet or an electromagnet.

25. The portable device of claim 1, wherein the magnet is capable of generating a uniform static magnetic field across substantial portion of the space.

26. The portable device of claim 1, wherein the magnet is capable of generating a static magnetic field strength of from about 0.01 Tesla (T) to about 30 T.

27. The portable device of claim 1, wherein the magnet is capable of generating a static magnetic field strength of from about 0.1 T to about 5.0 T.

28. The portable device of claim 1, wherein the magnet is capable of generating a static magnetic field strength of from about 0.1 T to about 2.0 T.

29. A method comprising:

providing a portable device, the device comprising a console, a strip, the strip comprising a space for holding a liquid sample and a microcoil capable of generating an excitation magnetic field across at least a portion of the space, and a magnet capable of generating a static magnetic field across at least a portion of the space;

providing a liquid sample within the space;

placing the strip into the console;

using the magnet to generate a static magnetic field across at least a portion of the sample;

using the microcoil to generate an excitation magnetic field across at least a portion of the sample;

detecting signals from the sample.

30. The method of claim 29, wherein the static magnetic field and the excitation magnetic field create Nuclear Magnetic Resonance (NMR) within the liquid sample.

31. The method of claim 29, wherein the detecting of signals from the sample is by the microcoil.

32. The method of claim 29, wherein the console comprises circuitry capable of detecting, processing, or analyzing the signals from the sample.

33. The method of claim 32, wherein the detecting of signals from the sample in by the circuitry.

34. The method of claim 29, further comprising generating an NMR spectroscopy of the liquid sample.

35. The method of claim 29, wherein the strip is placed into the console through an opening on the console.

36. The method of claim 35, wherein the opening is a slot.

37. The method of claim 29, wherein the providing a liquid sample within the space comprises introducing two or more different samples into the space.

38. A portable device comprising:

a console;

a strip, the strip comprising a space for holding a liquid sample and an array of microcoils capable of generating excitation magnetic fields across at least a portion of the space; and

a magnet capable of generating a static magnetic field across at least a portion of the space;

wherein the strip is capable of being placed within the console and wherein the static magnetic field and the excitation magnetic fields are capable of creating Nuclear Magnetic Resonance (NMR) within a liquid sample contained in the space; and

wherein the microcoil is capable of detecting signals from the NMR.

39. The portable device of claim 38, wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across a distinct portion of the space.

40. The portable device of claim 39, wherein the strip comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces.

41. The portable device of claim 38, wherein the space for holding a liquid sample comprises a reservoir, a microchannel, an opening, a surface, or a combination thereof.

42. The portable device of claim 38, wherein the space for holding a liquid sample has a volume of from about 1.0 nL to about 10 mL.

43. The portable device of claim 38, wherein the substrate comprises an array of spaces for holding liquid samples and wherein each of the spaces has a volume of from about 10 nL to about 100 μ

L.

44. A method comprising:

providing a portable device, the device comprising a console, a strip, the strip comprising a space for holding a liquid sample and an array of microcoils capable of generating excitation magnetic fields across at least a portion of the space, and a magnet capable of generating a static magnetic field across at least a portion of the space;

providing a liquid sample within the space;

placing the strip into the console;

using the magnet to generate a static magnetic field across at least a portion of the sample;

using at least a portion of the microcoils to generate an excitation magnetic field across at least a portion of the sample;

detecting signals from the sample.

45. The method of claim 44, wherein the static magnetic field and the excitation magnetic fields create Nuclear Magnetic Resonance (NMR) within the liquid sample.

46. The method of claim 44, wherein the detecting of signals from the sample is by at least a portion of the microcoils.

47. The method of claim 44, wherein the strip comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is used to generate an excitation magnetic field across one of the spaces.

48. The method of claim 44, wherein the magnet is capable of generating a uniform static magnetic field across at least a portion of the space for holding a liquid sample.

49. The method of claim 44, further comprising generating an NMR spectroscopy of the liquid sample.

50. The method of claim 44, wherein each of at least a portion of the microcoils is associated with a biomolecule.

51. The method of claim 50, wherein the biomolecule is a DNA capable of hybridizing with a complementary DNA.

52. The method of claim 51, wherein signals from the DNA hybridization is detected by at least a portion of the microcoils.

53. A method comprising:

fabricating a space for holding a liquid sample on a strip;

fabricating a microcoil on the strip, the microcoil being capable of generating an excitation magnetic field across at least a portion of the space;

fabricating a console, the console comprising an opening through which the strip can be placed within the console; and

attaching a magnet to the console or the strip, the magnet being capable of generating a static magnetic field across at least a portion of the space;

wherein the static magnetic field and the excitation magnetic field are capable of creating Nuclear Magnetic Resonance (NMR) within a liquid sample contained in the space; and

wherein the microcoil is capable of detecting signals from the NMR.

54. The method of claim 53, wherein the fabricating of the space or the fabricating of the microcoil comprises combining two or more substrates to form the strip.

55. The method of claim 53, further comprising forming circuitry on the strip, the circuitry being capable of amplifying or processing the NMR signals detected by the microcoil.

56. The method of claim 53, wherein the fabricating of the microcoil comprises fabricating an array of microcoils capable of generating an excitation magnetic field across at least a portion of the space.

57. The method of claim 56, wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across a distinct portion of the space.

58. The method of claim 56, wherein the strip comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces.

59. The method of claim 53, wherein the magnet is attached to the console.

60. The method of claim 53, wherein the magnet is attached to the strip.