Self-assembling cross-linking molecular nano film

• US 20070154519A1
• Filed: 12/29/2005
• Published: 07/05/2007
• Est. Priority Date: 12/29/2005
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Yang, Zhongping
• Granted Patent: US 8,535,704 B2
• Time in Patent Office: Days
• US Class Current: 424/424
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

The present invention is a molecular nano film formed on a surface of an implantable medical device to provide a barrier to tissue attachment. The film comprises self-assembling cross-linking molecules.

Claims

1. A molecular nano film that provides a barrier to tissue attachment, wherein the film comprises self-assembling cross-linking molecules.

2. The film of claim 1, wherein the film at least partially covers surfaces of an implantable medical device.

3. The film of claim 1, wherein the film is a monolayer.

4. The film of claim 3, wherein each monolayer has a thickness in a range of about 2 nanometers to about 10 nanometers.

5. The film of claim 3, wherein the film comprises a plurality of monolayers, thereby creating a multilayer film structure.

6. The film of claim 1, wherein the film is porous, with a pore size in a range of about 0.2 nanometers to about 500 nanometers.

7. The film of claim 1, wherein the film is non-conductive when dry and ionic conductive when wet.

8. The film of claim 1, wherein the film comprises functional silane molecules deposited through at least one of molecular layer deposition, chemical vapor deposition, solution immersion, and combinations thereof.

9. The film of claim 8, wherein the molecules are chosen from a group consisting essentially of:

fluorocarbon-alkyltrichlorosilane, hydrocarbon-alkyltrichlorosilane, ethylene oxide-alkyltrichlorosilane, a halide-alkylsilane, alkylsilane, an ethylene oxide-halidealkylsilane, and combinations thereof.

10. An implantable medical device, comprising an external surface coated with a conductive self-assembling cross-linking molecular nano film that provides a barrier to tissue attachment, wherein the film at least partially covers the external surface.

11. The implantable medical device of claim 10, wherein the film comprises a monolayer.

12. The implantable medical device of claim 11, wherein the monolayer has a thickness in a range of about 2 nanometers to about 10 nanometers.

13. The implantable medical device of claim 11, wherein the film comprises a plurality of monolayers, thereby creating a multilayer film structure.

14. The implantable medical device of claim 10, wherein the film is porous, with a pore size in a range of about 0.2 nanometers to about 500 nanometers.

15. The implantable medical device of claim 10, wherein the film comprises functional silane molecules deposited through at least one of molecular layer deposition, chemical vapor deposition, solution immersion, and combinations thereof.

16. The implantable medical device of claim 15, wherein the molecules include at least one of a fluorocarbon-alkyltrichlorosilane, hydrocarbon-alkyltrichlorosilane, ethylene oxide-alkyltrichlorosilane, a halide-alkylsilane, alkylsilane, an ethylene oxide-halidealkylsilane, and combinations thereof.

17. A method of providing a conductive barrier to tissue attachment on an implantable medical device, the method comprising:

hydroxylating at least one surface of the device; and

binding functional silane molecules to the hydroxylated surface of the device, thereby forming a self-assembling cross-linking monolayer nano film.

18. The method of claim 17, wherein binding the functional silane molecules includes at least one of molecular layer deposition, chemical vapor deposition, solution immersion, and combinations thereof.

19. The method of claim 17, wherein each monolayer of the film has a thickness in a range of about 2 nanometers to about 10 nanometers.

20. The method of claim 17, wherein the film comprises a plurality of monolayers, thereby creating a multilayer film structure.