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Method of increasing testosterone and related steriod concentrations in women

  • US 20070154533A1
  • Filed: 04/11/2006
  • Published: 07/05/2007
  • Est. Priority Date: 04/13/2005
  • Status: Abandoned Application
First Claim
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1. A method of treating, preventing or reducing the risk of developing a testosterone-deficient disorder in a female subject in need thereof, comprising:

  • (i) identifying a female subject having, or at risk of developing, a testosterone-deficient disorder;

    (ii) administering an amount of a hydroalcoholic gel pharmaceutical composition to an area of skin of the subject, which delivers a therapeutically-effective amount of testosterone to the blood serum of the subject such that the testosterone-deficient disorder is improved or the risk of developing a testosterone-deficient disorder is reduced, wherein the composition comprises;

    a. about 0.1% to about 10% (w/w) testosterone, or a salt, ester, amide, enantiomer, isomer, tautomer, prodrug, or derivative thereof;

    b. about 30% to about 98% (w/w) alcohol selected from the group consisting of ethanol or isopropanol;

    c. about 0.1% to about 5% (w/w) penetration enhancer;

    d. about 0.1% to about 5% (w/w) of a gelling agent; and

    e. the balance purified water;

    wherein the composition is capable of releasing the testosterone to the skin at a rate and duration that raises testosterone blood serum concentration to at least about 3 pg testosterone/ml blood serum within about 24 hours after administration.

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