Anti-inflammatory agent

• US 20070154575A1
• Filed: 10/25/2006
• Published: 07/05/2007
• Est. Priority Date: 10/26/2005
• Status: Active Grant

• Current Assignee: Oryza Oil & Fat Chemical Co. Ltd
• Original Assignee: Oryza Oil & Fat Chemical Co. Ltd
• Inventors: Okada, Tadashi, Tanaka, Junji, Shimoda, Hiroshi, Shan, Shaojie, Murai, Hiromichi
• Granted Patent: US 8,017,162 B2
• Time in Patent Office: Days
• US Class Current: 424/756
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/7008 Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
• CPC Class Codes: A61K 36/9068 Zingiber, e.g. garden ginger

Abstract

This invention provides an anti-inflammatory agent or the like which is safer and less adverse and has the great effectiveness to prevent and treat arthritis, or the like. An anti-inflammatory agent or the like in this invention is characterized by comprising anthocyanidin and gingerol as an active substance. Also, the abovementioned anthocyanidin and gingerol are preferably extracted from red ginger.

Claims

1. A composition comprising a red ginger extract effective to inhibit inflammation.

6. A composition of claim 1 further comprising an amino sugar and/or its salt.

7. A composition of claim 6 wherein the amino sugar is glucosamine.

8. A medicine comprising the composition described in claim 1.

9. A food and drink comprising the composition described in claim 1.

10. A dermatological agent for external skin use comprising the composition described in claim 1.

11. An inhibition method by using the composition described in claim 1.

12. A prevention method or a treatment method for arthritis or rheumatism by using the composition described in claim 1.

13. An antipyretic method by using the composition described in claim 1.

14. An analgesic method by using the composition described in claim 1.

2. A composition comprising an anthocyanidin and a gingerol effective to inhibit inflammation.

3. A composition of claim 2 wherein the anthocyanidin and the gingerol are extracted from red ginger.

4. A composition of claim 2 further comprising a shogaol.

5. A composition of claim 4 wherein the shogaol is extracted from red ginger.

22. A composition of claim 2 further comprising an amino sugar and/or its salt.

23. A medicine comprising the composition described in claim 2.

24. A food and drink comprising the composition described in claim 2.

25. A dermatological agent for external skin use comprising the composition described in claim 2.

26. An inhibition method by using the composition described in claim 2.

27. A prevention method or a treatment method for arthritis or rheumatism by using the composition described in claim 2.

28. An antipyretic method by using the composition described in claim 2.

29. An analgesic method by using the composition described in claim 2.

15. A composition comprising the red ginger extract effective to inhibit a COX-2.

17. A composition of claim 15 further comprising a shogaol effective to inhibit a COX-2.

18. A composition described in claim 15 which is characterized in that a COX-2 activity promotes a COX-1 activity.

20. A red ginger extract of claim 18 which is characterized by comprising an anthocyanidin (0.5 to 5.0 wt %) and a gingerol (1.0 to 10 wt %), provided the entire weight of the red ginger extract is 100 wt %.

21. A red ginger extract of claim 18 characterized by further comprising shogaol.

16. A composition comprising anthocyanidin and gingerol effective to inhibit a COC-2.

30. A composition described in claim 16 which is characterized in that a COX-2 activity promotes a COX-1 activity.

19. A red ginger extract which is characterized by comprising an anthocyanidin and a gingerol.