METHODS FOR COATING SURFACES WITH ANTIMICROBIAL AGENTS

• US 20070154621A1
• Filed: 11/15/2006
• Published: 07/05/2007
• Est. Priority Date: 11/18/2005
• Status: Abandoned Application

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: RAAD, ISSAM
• Application Number:
  US11/560,300
• Publication Number:
  US 20070154621A1
• Time in Patent Office: Days
• US Class Current: 427/2.100
• CPC Class Codes: A01N 25/24 containing ingredients to enhance the sticking of the active ingredients
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 37/44 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
• CPC Class Codes: A01N 43/90 having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/442 Colorants, dyes
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

Disclosed are methods for coating or impregnating a surface with an antimicrobial agent that involve contacting the surface with a composition that includes an antimicrobial agent and a solvent, and curing the surface by applying heat. Also disclosed are methods for reducing the risk of development or progression of an infection in a subject in need of a medical device, that involve coating or impregnating a surface of the medical device with an antimicrobial agent and then curing the surface by applying heat, wherein the risk of development or progression of an infection is reduced.

Claims

1. A method for coating or impregnating a non-organic surface with an antimicrobial agent, comprising:

a) contacting the non-organic surface with an composition comprising an antimicrobial agent and a solvent; and

b) curing the non-organic surface at a temperature that is at least about 40°

C., wherein at least some of the solvent that was contacted with the surface is removed, and wherein the antimicrobial agent coats or impregnates the surface.

2. The method of claim 1, further defined as a method for coating or impregnating a medical device with an antimicrobial agent, wherein the non-organic surface is the surface of a medical device.

3. The method of claim 2, wherein the medical device is an endotracheal tube, a tracheotomy tube, chest tube, a vascular catheter, an urinary catheter, a nephrostomy tube, a biliary stent, a peritoneal catheter, an epidural catheter, a central nervous system catheter, an orthopedic device, a prosthetic valve, a gastric tube, an intestinal tube, or drug-delivery implant.

4. The method of claim 3, wherein the medical device is a vascular catheter selected from the group consisting of a central venous catheter, an arterial line, a pulmonary artery catheter, a stent, and a peripheral venous catheter, an infusion port, or a dialysis catheter.

5. The method of claim 3, wherein the medical device is a central nervous system catheter further defined as an intraventricular shunt.

6. The method of claim 1, wherein the non-organic surface is a surface of a glove, a condom, a gown, hospital equipment, a table, a container, a countertop, a floor, a bag, a suture, a device used in food-processing, a sponge, or a mop.

7. The method of claim 1, wherein the antimicrobial agent is further defined as an antibiotic, an antiseptic, an antiviral agent, an antifungal agent, or a disinfectant.

8. The method of claim 7, wherein the antimicrobial agent is an antibiotic.

9. The method of claim 8, wherein the antibiotic is a tetracycline, a macrocyclic antibiotic compound, or a combination thereof.

10. The method of claim 9, wherein the tetracycline is minocycline.

11. The method of claim 9, wherein the macrocyclic antibiotic is rifampin, rifampicin, or a combination thereof.

12. The method of claim 8, wherein the composition comprises tetracycline and minocycline.

13. The method of claim 7, wherein the antimicrobial agent is an antiseptic.

14. The method of claim 7, wherein the antimicrobial agent is a disinfectant.

15. The method of claim 1, wherein the antimicrobial agent comprises a dye, a basic reagent, or a combination thereof.

16. The method of claim 15, wherein the composition comprises a basic reagent and a dye.

17. The method of claim 16, wherein the basic reagent is a guanidium compound, a biguanide, a bipyridine, a phenoxide antiseptic, an alkyl oxide, an aryl oxide, a thiol, a halide, an aliphatic amine, or an aromatic amine.

18. The method of claim 17, wherein the basic reagent is a guanidium compound.

19. The method of claim 18, wherein the guanidium compound is chlorhexidine, alexidine, or hexamidine.

20. The method of claim 17, wherein the basic reagent is a bipyridine.

21. The method of claim 20, wherein the bipyridine is octenidine.

22. The method of claim 17, wherein the basic reagent is a phenoxide antiseptic.

23. The method of claim 22, wherein the phenoxide antiseptic is clofoctol, chloroxylenol, or triclosan.

24. The method of claim 16, wherein the dye is a triarylmethane dye, a monoazo dye, a diazo dye, an indigoid dye, a xanthene dye, an anthraquinone dye, a quinoline dye, an FD&

C dye, a D&

C dye, or brilliant green.

25. The method of claim 24, wherein the dye is a triarylmethane dye selected from the group consisting of gentian violet, crystal violet, and ethyl violet.

26. The method of claim 25, wherein the FD&

C dye is Blue No. 1 or Green No. 3.

27. The method of claim 24, wherein the monoazo dye is FD&

C Yellow No. 5 or FD&

C Yellow No. 6.

28. The method of claim 24, wherein the diazo dye is D&

C Red No. 17.

29. The method of claim 24, wherein the indigoid dye is FD&

C Blue No. 2.

30. The method of claim 24, wherein the xanthene dye is FD&

C Red No. 3.

31. The method of claim 24, wherein the anthraquinone dye is D&

C Green No. 6.

32. The method of claim 24, wherein the quinoline dye is D&

C Yellow No. 1.

33. The method of claim 1, wherein the surface comprises a micropore or a nanopore.

34. The method of claim 1, wherein curing comprises heating the surface to a temperature that is about 40°

C. to about 100°

C.

35. The method of claim 24, wherein curing comprises heating the surface to a temperature that is about 40°

C. to about 80°

C.

36. The method of claim 35, wherein curing comprises heating the surface to a temperature that is about 40°

C. to about 60°

C.

37. The method of claim 36, wherein the surface is heated for about 1 hour to about 3 weeks.

38. The method of claim 37, wherein the surface is heated for about 12 hours to about 96 hours.

39. The method of claim 38, wherein the surface is heated for about 24 hours to about 72 hours.

40. The method of claim 1, wherein curing is further defined as drying the surface.

41. The method of claim 1, further comprises washing the surface after curing the surface.

42. The method of claim 41, wherein washing is further defined as contacting the surface with a composition comprising a detergent and water.

43. The method of claim 41, further comprising curing the surface at a temperature of at least 40°

C. after washing the surface.

44. The method of claim 43, wherein the surface is cured for at least 1 hour to at least 96 hours.

45. The method of claim 44, wherein the surface is cured for at least 24 hours to at least 72 hours.

46. The method of claim 1, wherein the surface is composed of a polymer or silicone.

47. The method of claim 46, wherein the polymer is polyvinyl chloride, polyurethane, polyethylene, silastic elastomers, polytetrafluoroethylene, dacron, collodion, carboethane or nylon.

48. The method of claim 2, further comprising packaging the medical device in a container.

49. The method of claim 2, further comprising sterilizing the medical device.

51. A method for reducing the risk of development or progression of an infection in a subject in need of a medical device, comprising coating or impregnating a surface of the medical device with an antimicrobial agent in accordance with the method of claim 1 prior to contacting the medical device with the subject, wherein the risk of development or progression of an infection is reduced.

52. The method of claim 51, wherein the subject is a human.

53. The method of claim 51, wherein the antimicrobial agent is further defined as an antibiotic, an antiseptic, an antiviral agent, an antifungal agent, or a disinfectant.

54. The method of claim 53, wherein the antimicrobial agent is an antibiotic.

55. The method of claim 54, wherein the antibiotic is a tetracycline, a macrocyclic antibiotic compound, or a combination thereof.

56. The method of claim 55, wherein the tetracycline is minocycline.

57. The method of claim 55, wherein the macrocyclic antibiotic is rifampin, rifampicin, or a combination thereof.

58. The method of claim 51, wherein the infection is pneumonia, bacteremia, fungimia, candidemia, a urinary tract infection, a catheter-exit site infection, or a surgical wound infection.

59. The method of claim 51, wherein the infection is a nosocomial infection.

60. The method of claim 59, wherein the infection is caused by methicillin-resistant staphylococci, vancomycin-resistant enterococci, resistant Pseudomonas aeruginosa, or a combination thereof.

61. The method of claim 59, wherein the infection is a fungal infection secondary to Candida species.

62. The method of claim 51, wherein the antimicrobial agent is an antibacterial agent, an antiviral agent, or an antifungal agent.

63. The method of claim 62, wherein the antibacterial agent is minocycline or rifampin.

64. The method of claim 51, wherein the composition comprises a basic reagent and a dye.

65. The method of claim 51, wherein the medical device is an endotracheal tube, a vascular catheter, an urinary catheter, a nephrostomy tube, a biliary stent, a peritoneal catheter, an epidural catheter, a central nervous system catheter, an orthopedic device, a prosthetic valve, a silk suture, or a medical implant.

66. The method of claim 65, wherein the medical device is a vascular catheter further defined as a central venous catheter, an arterial line, an pulmonary artery catheter, or a peripheral venous catheter.

67. The method of claim 65, wherein said central nervous system catheter is an intraventricular shunt.

50. A method for coating or impregnating a medical device with an antimicrobial composition, comprising the steps of:

a) contacting the medical device with a composition comprising an antimicrobial agent and a solvent;

b) curing the medical device at a temperature of about 40°

C. to about 80°

C. for about 12 hours to about 72 hours, wherein the medical device is dried;

c) washing the medical device with an aqueous composition; and

d) repeating step b),

wherein the medical device becomes coated or impregnated with an antimicrobial composition.