Multi-assay microfluidic chips
First Claim
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1. A method of microfluidic analysis, the method comprising:
- consecutively receiving two or more samples into a microfluidic device;
consecutively receiving two or more different reagents into the microfluidic device;
contacting the samples with the reagents in the device, wherein at least two of the samples contact at least one of the reagents and at least two of the reagents contact at least one of the samples; and
, detecting signals resulting from three or more of the contacts between samples and reagents.
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Abstract
This invention provides systems and methods of running multiple different analyses on a microfluidic device. Results from such analyses can be useful in high throughput screening of samples or correlation of multiple as
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Citations
41 Claims
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1. A method of microfluidic analysis, the method comprising:
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consecutively receiving two or more samples into a microfluidic device;
consecutively receiving two or more different reagents into the microfluidic device;
contacting the samples with the reagents in the device, wherein at least two of the samples contact at least one of the reagents and at least two of the reagents contact at least one of the samples; and
,detecting signals resulting from three or more of the contacts between samples and reagents. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system for analyzing a matrix of sample to reagent combinations, the system comprising:
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a first pipettor tube configured to sequentially receive two or more samples;
a second pipettor tube configured to sequentially receive two or more reagents;
a microfluidic device comprising a reaction channel in fluid connection with the first pipettor tube and with the second pipettor tube, whereby the samples and reagents can come into contact in the channel; and
,a detector configured to detect one or more signals resulting from the contact of one or more of the samples with one or more of the reagents;
wherein resultant signals are detected for the contact of each of two or more samples separately with each of two or more reagents, thereby analyzing a matrix of samples to reagents. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of multiple analyses, the method comprising:
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receiving a sample into a microfluidic device;
contacting the sample with a plurality of different reagents in the device;
separately detecting signals resulting from two or more of the contacts between the reagents and the sample; and
,evaluating the resultant signals to determine the presence or quantity of one or more sample analytes;
thereby providing multiple analysis results for the sample. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A system for conducting multiple sample analyses, the system comprising:
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a microfluidic device comprising one or more reaction channels;
two or more different reagents in the one or more reaction channels; and
,one or more detectors configured to detect one or more signals resulting from two or more of the contacts between the reagents and one or more samples;
whereby the resultant signals can be evaluated to determine a presence or quantity of two or more analytes in the sample;
thereby conducting multiple sample analyses. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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Specification