Insulin-producing cells derived from stem cells
First Claim
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1. An insulin-producing cell derived from a neural or neuroendocrine stem cell.
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Abstract
The disclosure provides, among other things, insulin-producing cells derived from stem cells, such as human stem cells and neural stem cells. The disclosure discloses a relationship between caudalizing factors and the differentiation of insulin-producing cells.
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Citations
53 Claims
- 1. An insulin-producing cell derived from a neural or neuroendocrine stem cell.
- 6. A cell cluster derived from neural or neuroendocrine stem cells, wherein the cell cluster comprises insulin-producing cells.
- 10. A method for making a cell composition comprising cells that are receptive to treatment with an islet cell differentiation factor, the method comprising culturing stem cells with a neural/endoderm caudalizing factor.
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17. (canceled)
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18. A method for producing insulin-producing cells, the method comprising:
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a. culturing human stem cells with a neural/endoderm caudalizing factor to obtain a first cell composition;
b. culturing the first cell composition, or a portion thereof, with an islet cell differentiation factor, thereby obtaining a second cell composition comprising insulin-producing cells. - View Dependent Claims (19, 20, 21, 22, 23, 27, 28, 29, 30, 40)
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24-26. -26. (canceled)
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31-39. -39. (canceled)
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41-44. -44. (canceled)
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45. A method for ameliorating, in a subject, a condition related to insufficient pancreatic function, the method comprising:
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a. obtaining from the subject or an HLA-matched donor a sample comprising neural or neuroendocrine stem cells;
b. culturing one or more of the neural or neuroendocrine stem cells in the presence of a neural/endoderm caudalizing factor to obtain a first cell composition;
c. culturing the first cell composition in the presence of an islet cell differentiation factor to obtain a second cell composition, wherein the second cell composition comprises insulin producing cells; and
d. administering to the subject an effective amount of insulin-producing cells. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53)
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Specification