High throughput cell-based assays fabricated with integrated silicon and cell culture technologies
First Claim
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1. An apparatus comprising:
- a membrane, the membrane comprising;
a first side;
a second, opposing side; and
a plurality of pores spanning the membrane from the first side to the second side, wherein the membrane comprises primarily inorganic material, and wherein the apparatus is configured for cell culturing and/or performing a cell assay.
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Abstract
The present invention relates to articles and methods involving porous materials (e.g., membranes) which may interact with species, such as biological molecules, cells, etc., whereby the species may adhere to or become immobilized with respect to a surface of the porous material or an adhesion layer coating the porous surface. The porous material may be capable of attaching species with control over the positioning and spatial distribution of the species across the surface of the material. Such articles and methods may be useful in, for example, biological assays, biological sensors, or in the culturing of biological cells.
17 Citations
85 Claims
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1. An apparatus comprising:
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a membrane, the membrane comprising;
a first side;
a second, opposing side; and
a plurality of pores spanning the membrane from the first side to the second side, wherein the membrane comprises primarily inorganic material, and wherein the apparatus is configured for cell culturing and/or performing a cell assay. - View Dependent Claims (67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
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2-66. -66. (canceled)
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85. An article for cell culturing and/or cell assay, comprising:
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a membrane having a first side and a second, opposing side;
a plurality of pores spanning the membrane from the first side to the second side and a cell adhesive material layer positioned on the first side of the membrane such that the cell adhesive material layer is exposed through the pores to an environment in contact with the second, opposing side and occludes at least some of the plurality of pores.
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Specification