Method and device for selectively detecting ferromagnetic or superparamagnetic particles.
First Claim
1. A method of selectively detecting and/or quantifying super paramagnetic and/or ferro magnetic particles, characterized in that based upon the nonlinearality of the magnetization characteristics of the particles, frequency components of magnetic fields generated by their magnetization are measured in terms of mixed frequencies.
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Abstract
The invention relates to a method for selectively detecting and/or quantifying superparamagnetic and/or ferromagnetic particles on analytes. The method is characterized in that a frequency component of magnetic fields (15, 18), which is generated due to the non-linearity of the magnetization characteristic curve of the particles, is measured at a mixing frequency. A device for selectively detecting and/or quantifying superparamagnetic and/or ferromagnetic particles on analytes comprises: a container (12) that contains particles, which are to be detected and/or quantified, on analytes; at least one oscillator (13, 16; 25) for generating frequencies of alternating magnetic fields (15, 18); at least one field generator (14, 17) for subjecting the analytes to alternating magnetic fields (15, 18); a magnetic field sensor (20) for measuring a response magnetic field (19) of the particles, and; at least one phase-sensitive detector (21, 23). These elements are configured in such a manner as to enable a frequency component of the magnetic fields (15, 18), which is generated due to the non-linearity of the magnetization characteristic curve of the particles, to be measured at a mixing frequency.
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Citations
27 Claims
- 1. A method of selectively detecting and/or quantifying super paramagnetic and/or ferro magnetic particles, characterized in that based upon the nonlinearality of the magnetization characteristics of the particles, frequency components of magnetic fields generated by their magnetization are measured in terms of mixed frequencies.
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3. The method according to claim in which the modulating magnetic field (4, 18) has a frequency between 50 and 100 hertz.
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12. A device for the selective detection and/or quantification of super power magnetic and/or thermal magnetic particles with analytes, comprising:
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a vessel (12) with an analyte to be detected or to be quantified, at least one oscillator (13, 16;
25) for producing frequencies of alternating magnetic fields (15, 18),at least one field generator (14, 17) for subjecting the analyte to alternating magnetic field (15, 18), a magnetic field sensor (20) for measuring a response magnetic field (19) of the particles, and at least one phase sensitive detector (21, 23). - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 25, 26, 27)
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Specification