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RNAi-mediated inhibition of HIF1A for treatment of ocular angiogenesis

  • US 20070155690A1
  • Filed: 12/19/2006
  • Published: 07/05/2007
  • Est. Priority Date: 12/29/2005
  • Status: Abandoned Application
First Claim
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1. A method of attenuating expression of HIF1A mRNA of a subject, comprising:

  • administering to the subject a composition comprising an effective amount of interfering RNA having a length of 19 to 49 nucleotides and a pharmaceutically acceptable carrier, the interfering RNA comprising;

    a sense nucleotide strand, an antisense nucleotide strand, and a region of at least near-perfect contiguous complementarity of at least 19 nucleotides;

    wherein the antisense strand hybridizes under physiological conditions to a portion of MRNA corresponding to SEQ ID NO;

    1 or SEQ ID NO;

    2 and has a region of at least near-perfect contiguous complementarity of at least 19 nucleotides with the hybridizing portion of MRNA corresponding to SEQ ID NO;

    1 or SEQ ID NO;

    2, respectively, wherein the expression of HIF1A mRNA is attenuated thereby.

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