Glaucoma Treatment Devices and Methods

• US 20070156079A1
• Filed: 09/14/2006
• Published: 07/05/2007
• Est. Priority Date: 09/16/2005
• Status: Abandoned Application

• Current Assignee: BG Implant Incorporated
• Original Assignee: BG Implant Incorporated
• Inventors: Brown, J.
• Application Number:
  US11/531,965
• Publication Number:
  US 20070156079A1
• Time in Patent Office: Days
• US Class Current: 604/9
• CPC Class Codes: A61B 3/16 for measuring intraocular pressure, e.g. tonometers
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

This document provides methods and materials related to treating glaucoma. For example, devices that can be implanted into a human'"'"'s eye to treat glaucoma, methods for treating glaucoma, compositions for reducing polypeptide clogging of implanted devices, and methods for making devices for treating glaucoma are provided.

Claims

1. A device for treating glaucoma in an eye, comprising:

a body defining a lumen and having first and second ends and external and lumenal surfaces, said body having a length sufficient to provide fluid communication between the anterior chamber and tear film of an eye through said lumen when said device is implanted in the sclera; and

a flexible filter membrane capable of providing outflow resistance to aqueous humor flowing through said lumen and capable of flexing in response to an increase in intraocular pressure.

2. The device of claim 1, wherein said second end of said device is adapted to lie substantially flush with the scleral surface when said device is implanted in the sclera.

3. The device of claim 1, wherein said body is flared at said second end.

4. The device of claim 1, wherein said body comprises a material selected from the group consisting of silicone, acrylic, polyimide, polypropylene, polymethyl methacrylate, polytetrafluoroethylene, hydrogels, polyolefin, polyvinylchloride, and polyester.

5. The device of claim 1, wherein said flexible filter membrane comprises polydimethylsiloxane, a silicone rubber, or a hydrogel.

6. The device of claim 1, wherein said flexible filter membrane is a microporous/nanoporous filter membrane or a debris filter.

7. The device of claim 1, wherein said flexible filter membrane is a microporous/nanoporous filter membrane and comprises micropores having a diameter less than or equal to about 0.2 microns.

8. The device of claim 1, wherein said flexible filter membrane is a debris filter and comprises pores having a diameter between about 0.5 and 2 microns.

9. The device of claim 8, wherein said debris filter comprises an inflow face, an outflow face, and a peripheral edge contiguous with said body.

10. The device of claim 1, wherein said device comprises a microporous/nanoporous filter membrane and a debris filter.

11. The device of claim 10, wherein said debris filter is positioned at said first end or between said first end and said microporous/nanoporous filter membrane.

12. The device of claim 11, wherein said flexible filter membrane is positioned between said debris filter and said microporous/nanoporous filter membrane.

13. The device of claim 10, wherein said microporous/nanoporous filter membrane comprises a pressure sensor.

14. The device of claim 13, wherein said pressure sensor comprises photonic crystals.

15. The device of claim 14, wherein said photonic crystals are within a polymer network of a hydrogel.

16. The device of claim 10, wherein said body and said microporous/nanoporous filter membrane comprise the same material.

17. The device of claim 16, wherein said body and said microporous/nanoporous filter membrane are fused together using heat.

18. The device of claim 17, wherein said body and said microporous/nanoporous filter membrane comprise polyolefin, polypropylene, polytetrafluoroethylene, polyvinylchloride, or polyester.

19. The device of claim 10, wherein said device comprises a second debris filter.

20. The device of claim 19, wherein said second debris filter is positioned at or near the second end of the body, external to said microporous/nanoporous filter membrane.

21. The device of claim 1, wherein the flexing of said flexible filter membrane in response to an increase in intraocular pressure reduces said outflow resistance.

22. The device of claim 1, wherein said flexible filter membrane comprises a pressure sensor.

23. The device of claim 22, wherein said pressure sensor comprises photonic crystals.

24. The device of claim 23, wherein said photonic crystals are within a polymer network of a hydrogel.

25. The device of claim 1, wherein said body and said flexible filter membrane comprise different materials.

26. The device of claim 25, wherein said body and said flexible filter membrane are fused together using heat.

27. The device of claim 25, wherein said body and said flexible filter membrane comprise polyolefin, polypropylene, polytetrafluoroethylene, polyvinylchloride, or polyester.

28. A method for treating glaucoma, comprising:

(a) providing a device comprising a body defining a lumen and having first and second ends, said body having sufficient length to provide fluid communication between the anterior chamber and tear film of an eye, and said device comprising a flexible filter membrane capable of providing outflow resistance to aqueous humor and capable of flexing in response to an increase in intraocular pressure; and

(b) implanting said device in the sclera of the eye such that aqueous humor flows from the anterior chamber to the tear film of the eye.

29. A method for making a device for treating glaucoma in an eye, said method comprising using heat to fuse a body to a filter membrane to form said device, wherein said body comprises a lumen, first and second ends, and external and lumenal surfaces, said body having a length sufficient to provide fluid communication between the anterior chamber and tear film of an eye through said lumen when said device is implanted in the sclera, and wherein said filter membrane is capable of providing outflow resistance to aqueous humor flowing through said lumen.

30. The method of claim 29, wherein said body and said filter membrane comprise different materials.

31. The method of claim 30, wherein said body comprises a heat shrink material.

32. The method of claim 30, wherein said material is selected from the group consisting of polyolefin, polypropylene, polytetrafluoroethylene, polyvinylchloride, and polyester.

33. A method for reducing polypeptide clogging in a device implanted in the sclera of an eye, said method comprising administering a solution comprising particles containing a protease, a surfactant, heparin, or a combination thereof to said eye under conditions wherein polypeptides clogging said device are cleaved or removed.

34. The method of claim 33, wherein said device comprises a body defining a lumen and having first and second ends, said body having sufficient length to provide fluid communication between the anterior chamber and tear film of the eye, and said device comprising a filter membrane capable of providing outflow resistance to aqueous humor.

35. The method of claim 34, wherein said device comprises a flexible filter membrane capable of flexing in response to an increase in intraocular pressure.

36. The method of claim 35, wherein said flexible filter membrane is said filter membrane.

37. The method of claim 33, wherein said solution is a biocompatible solution.

38. The method of claim 33, wherein said solution is an eye drop solution.

39. The method of claim 33, wherein said particles are capable of degrading following administration to said eye.

40. The method of claim 33, wherein said particles comprise material selected from the group consisting of thermoplastic starch materials, mater-bi, polylatic acid, and poly-hydroxybutyrate-co-hydroxyvalerate.

41. The method of claim 33, wherein said protease is a papain or subtilisin protease.

42. A method for providing a patient with the ability to monitor intraocular pressure, comprising:

(a) providing a patient with a detector comprising a light source and a wavelength sensor, wherein the sclera of an eye of said patient comprises (i) a device comprising a body defining a lumen and having first and second ends and external and lumenal surfaces, said body having a length sufficient to provide fluid communication between the anterior chamber and tear film of said eye through said lumen and (ii) a flexible filter membrane capable of providing outflow resistance to aqueous humor flowing through said lumen and capable of flexing in response to an increase in intraocular pressure, wherein said flexible filter membrane comprises a pressure sensor; and

(b) instructing said patient to emit light from said detector onto said eye such that said detector is capable of detecting the wavelength of the emitted light that is reflected from said pressure sensor.

43. The method of claim 42, wherein said pressure sensor comprises photonic crystals.

44. The method of claim 43, wherein said photonic crystals are within a polymer network of a hydrogel of said flexible filter membrane.

45. The method of claim 42, wherein said light is emitted as white light.

46. The method of claim 42, wherein said detector records the wavelength of the emitted light that is reflected from said pressure sensor.

47. The method of claim 42, wherein said detector converts the detected wavelength of the emitted light that is reflected from said pressure sensor into a pressure value.

48. The method of claim 42, wherein said detector records the wavelength value of the emitted light that is reflected from said pressure sensor or a pressure value converted from said wavelength value, wherein said recorded wavelength value or pressure value is recorded with the time, day, or time and day that said detector detected said wavelength.

49. The method of claim 42, said detector records multiple wavelength values detected by said detector at different times or multiple pressure values converted from said multiple wavelength values.

50. A method for determining intraocular pressure in a patient, wherein the sclera of an eye of said patient comprises (i) a device comprising a body defining a lumen and having first and second ends and external and lumenal surfaces, said body having a length sufficient to provide fluid communication between the anterior chamber and tear film of said eye through said lumen and (ii) a flexible filter membrane capable of providing outflow resistance to aqueous humor flowing through said lumen and capable of flexing in response to an increase in intraocular pressure, wherein said flexible filter membrane comprises a pressure sensor, wherein said method comprises:

(a) providing a detector comprising a light source and a wavelength sensor; and

(b) emitting light from said detector onto the eye of said patient such that said detector is capable of detecting the wavelength of the emitted light that is reflected from said pressure sensor.

51. The method of claim 50, wherein said pressure sensor comprises photonic crystals.

52. The method of claim 50, wherein said photonic crystals are within a polymer network of a hydrogel of said flexible filter membrane.

53. The method of claim 50, wherein said light is emitted as white light.

54. The method of claim 50, wherein said detector records the wavelength of the emitted light that is reflected from said pressure sensor.

55. The method of claim 50, wherein said detector converts the detected wavelength of the emitted light that is reflected from said pressure sensor into a pressure value.

56. The method of claim 50, wherein said detector records the wavelength value of the emitted light that is reflected from said pressure sensor or a pressure value converted from said wavelength value, wherein said recorded wavelength value or pressure value is recorded with the time, day, or time and day that said detector detected said wavelength.

57. The method of claim 50, said detector records multiple wavelength values detected by said detector at different times or multiple pressure values converted from said multiple wavelength values.

58. A kit comprising a device and a detector, wherein said device comprises (a) a body defining a lumen and having first and second ends and external and lumenal surfaces, said body having a length sufficient to provide fluid communication between the anterior chamber and tear film of an eye through said lumen when said device is implanted in the sclera, and (b) a flexible filter membrane capable of providing outflow resistance to aqueous humor flowing through said lumen and capable of flexing in response to an increase in intraocular pressure, wherein said flexible filter membrane comprises a pressure sensor;

and wherein said detector comprises a light source and a wavelength sensor, wherein said detector is capable of emitting light onto an eye containing said device such that said detector is capable of detecting the wavelength of the emitted light that is reflected from said pressure sensor.