AUTOMATED CONTROL MECHANISMS AND METHODS FOR CUSTOM LENGTH STENT APPARATUS

• US 20070156225A1
• Filed: 12/21/2006
• Published: 07/05/2007
• Est. Priority Date: 12/23/2003
• Status: Abandoned Application

• Current Assignee: JW Medical Systems Ltd
• Original Assignee: XTENT, Inc.
• Inventors: Andreas, Bernard, George, Robert
• Application Number:
  US11/614,271
• Publication Number:
  US 20070156225A1
• Time in Patent Office: Days
• US Class Current: 623/1.120
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2/9517 handle assemblies therefor
• CPC Class Codes: A61F 2/966 with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
• CPC Class Codes: A61F 2250/0097 Visible markings, e.g. indicia
• CPC Class Codes: A61M 2025/0008 having visible markings on its surface, i.e. visible to the naked eye, for any purpose, e.g. insertion depth markers, rotational markers or identification of type
• CPC Class Codes: A61M 2025/1068 having means for varying the length or diameter of the deployed balloon, this variations could be caused by excess pressure
• CPC Class Codes: A61M 25/0136 Handles therefor

Abstract

Methods and apparatus for delivering prosthetic segments to a body lumen, utilize a delivery device having an elongated flexible member including proximal and distal ends, a plurality of prosthetic segments arranged near the distal end and axially along the elongated flexible member and an outer sheath slidably disposed over at least a portion of the prosthetic segments. The delivery device also includes a control mechanism coupled with the outer sheath and the elongated flexible member, wherein the control mechanism is adapted to retract the sheath a fixed distance, the fixed distance selectable by an operator to expose a selected number of prosthetic segments and create a spacing between a proximal prosthetic segment in the selected number and a distal prosthetic segment remaining with the elongated flexible member.

Claims

1. An apparatus for delivering prostheses in a body lumen, the apparatus comprising:

an elongated flexible member having a proximal end and a distal end;

a plurality of radially-expandable prostheses in an unexpanded condition arranged axially along the elongated flexible member near the distal end;

an outer sheath slidably disposed over at least a portion of the prostheses; and

a control mechanism coupled with the outer sheath and the elongated flexible member wherein the control mechanism includes means for selecting a plurality of prostheses to deploy in a range from 2 to 20, and wherein the control mechanism retracts the sheath a fixed distance to expose the selected plurality of prostheses outside the sheath in the unexpanded condition.

2. An apparatus as in claim 1, wherein the control mechanism is further adapted to create a space free of the prostheses between a proximal prosthesis in the selected plurality and a distal end of the sheath with the prostheses in the unexpanded condition.

3. An apparatus as in claim 2, wherein the control mechanism creates the space with a predetermined length.

4. An apparatus as in claim 3, wherein the control mechanism is adapted to permit operator adjustment of the length of the space after creating the space with the predetermined length.

5. An apparatus as in claim 4, wherein the control mechanism is adapted to be held by an operator using one hand while simultaneously being actuated with one or more fingers or a thumb of the one hand.

6. An apparatus as in claim 1, further comprising a handle coupled to the proximal end of the elongated flexible member.

7. An apparatus as in claim 1, wherein actuation of the control mechanism retracts the sheath a fixed distance equal to a predetermined multiple of the length of each prosthesis.

8. An apparatus as in claim 6, wherein the control mechanism comprises an actuator movably coupled to the handle.

9. An apparatus as in claim 8, wherein the handle is adapted to be held by an operator using one hand while simultaneously actuating the actuator with one or more fingers or a thumb of the one hand.

10. An apparatus as in claim 6, wherein the control mechanism comprises an axially movable slider disposed on the handle.

11. An apparatus as in claim 6, wherein the control mechanism comprises a pair of triggers pivotably coupled to the handle.

12. An apparatus as in claim 6, wherein the control mechanism comprises a lever.

13. An apparatus as in claim 8, wherein the actuator is movable through a fixed distance, and each actuation of the actuator through the fixed distance retracts the outer sheath a distance equal to the length of one of the prostheses or a predetermined multiple thereof.

14. An apparatus as in claim 2, wherein the control mechanism comprises an actuator movable through a fixed distance, and each actuation of the actuator through the fixed distance retracts the outer sheath a distance equal to the length of one prosthetic segment plus the predetermined length.

15. An apparatus as in claim 6, wherein the control mechanism comprises a selector switch disposed on the handle, the selector switch having a plurality of positions corresponding to different numbers of the prostheses to be included in the selected plurality.

16. An apparatus as in claim 15, wherein the control mechanism further comprises a movable actuator, wherein movement of the actuator retracts the sheath a distance which varies according to the position of the selector switch.

17. An apparatus as in claim 16, wherein the actuator is movable through a distance, wherein the distance varies according to the position of the selector switch.

18. An apparatus as in claim 16, wherein the actuator is movable through a fixed distance, and wherein moving the actuator through the fixed distance retracts the sheath a distance equal to the length of one of the prostheses or a predetermined multiple thereof.

19. An apparatus as in claim 6, wherein the control mechanism comprises a ratchet mechanism.

20. An apparatus as in claim 6, wherein the control mechanism comprises a rotationally movable mechanism.

21. An apparatus as in claim 6, wherein the control mechanism comprises a linearly movable mechanism.

22. An apparatus as in claim 21, wherein the control mechanism comprises a plurality of axially movable sliders on the handle, the sliders being movable through a fixed distance.

23. An apparatus as in claim 22, wherein a first of the sliders is movable through a first fixed distance and a second of the sliders is movable through a second fixed distance different than the first distance.

24. An apparatus as in claim 23, wherein when the first slider is moved through the first fixed distance the selected plurality of prostheses exposed outside the sheath is a different number than when the second slider is moved through the second fixed distance.

25. An apparatus as in claim 6, wherein the control mechanism is adapted to provide audible, visual or tactile feedback during actuation of the control mechanism to indicate the number of prostheses in the selected plurality.

26. An apparatus as in claim 6, wherein the control mechanism comprises a first control adapted to expose the selected number of prostheses and a second control adapted to create the spacing.

27. An apparatus as in claim 26, wherein the second control is an actuator movably coupled to the handle.

28. An apparatus as in claim 27, wherein the handle is adapted to be held by an operator using one hand while simultaneously actuating the second control with one or more fingers or a thumb of the one hand.

29. An apparatus as in claim 26, wherein the second control comprises an axially movable slider disposed on the handle.

30. An apparatus as in claim 26, wherein the second control comprises a lever pivotably coupled to a handle.

31. An apparatus as in claim 26, wherein the second control is rotationally movable.

32. An apparatus as in claim 26, wherein the second control is linearly movable.

33. An apparatus as in claim 26, wherein the second control is movable through a predetermined distance and wherein moving the second control through the fixed distance creates the spacing with a predetermined length.

34. An apparatus as in claim 33, wherein the second control is not movable beyond the predetermined distance.

35. An apparatus as in claim 33, wherein the second control provides feedback to the operator when moved through the predetermined distance.

36. An apparatus as in claim 35, wherein the feedback comprises a visual indicator associated with the second control.

37. An apparatus as in claim 35, wherein the feedback comprises a detent engaged by the second control.

38. An apparatus as in claim 33, wherein after moving through the fixed distance the second control is further movable to adjust the length of the spacing.

39. An apparatus as in claim 1, further comprising a pusher element disposed on the elongated flexible member and adapted to prevent the prostheses from axially moving toward the proximal end of the elongated flexible member.

40. An apparatus as in claim 1, further comprising an engaging member disposed near a distal end of the outer sheath and adapted to engage one or more of the prostheses so as to facilitate movement of the prostheses axially on the elongated flexible member.

41. An apparatus as in claim 1, further comprising a balloon coupled to the flexible member, wherein the prosthetic segments are positionable on the balloon for expansion therewith.

42. An apparatus as in claim 1, wherein the prostheses are self-expanding.

43. An apparatus as in claim 1, further comprising an expandable member near the distal end of the elongated flexible member.

44. An apparatus as in claim 43, wherein the sheath is adapted to constrain the expandable member from expansion when positioned over the expandable member.

45. An apparatus as in claim 44, wherein upon retraction of the sheath a selected portion of the expandable member is exposed for expansion of the selected plurality of prostheses.

46. An apparatus as in claim 43, wherein the expandable member is a balloon.

47. An apparatus as in claim 1, wherein the plurality of prostheses carry a therapeutic agent adapted to be released therefrom.

48. An apparatus as in claim 47, wherein the therapeutic agent comprises an anti-restenosis agent.

49. An apparatus as in claim 1, wherein the plurality of prostheses have a length in the range from about 2 mm to about 20 mm.

50. An apparatus as in claim 1, wherein the plurality of prostheses comprise segments having a length about 3 mm to 10 mm.

51. An apparatus as in claim 1, wherein the plurality of prostheses have the same length.

52. An apparatus as in claim 1, further comprising a switch having a first position and a second position, wherein upon actuation the control mechanism exposes the prostheses when the switch is in the first position and creates the spacing when the switch is in the second position.

53. An apparatus as in claim 1, wherein the plurality of prostheses have two or more lengths.

54. An apparatus as in claim 1, wherein the plurality of prostheses have ends in engagement with one another prior to deployment.

55. An apparatus as in claim 1, further comprising an indicator adapted to display the selected number of prostheses exposed from the sheath.

56. An apparatus as in claim 1, wherein the control mechanism comprises a length selector having a plurality of settings, each setting corresponding to a number of prostheses to be exposed, whereby upon actuation the sheath is retracted a distance to expose the number of prostheses corresponding to a selected setting.

57. An apparatus for delivering prostheses in a body lumen, the apparatus comprising:

an elongated flexible member having a proximal end and a distal end;

a plurality of prostheses arranged axially along the elongated flexible member near the distal end;

an outer sheath slidably disposed over at least a portion of the prostheses; and

a control mechanism coupled with the outer sheath and the elongated flexible member, the control mechanism having a first actuator which retracts the outer sheath a distance for exposing a selected number of prostheses, the control mechanism also having a second actuator which creates a space free of the prostheses between a proximal prosthesis in the selected number of prostheses and a distal end of outer sheath.

58. An apparatus as in claim 57, wherein the control mechanism creates the space with a predetermined length.

59. An apparatus as in claim 58, wherein the control mechanism is adapted to permit operator adjustment of the length of the space after creating the space with the predetermined length.

60. An apparatus as in claim 57, wherein actuation of the control mechanism retracts the sheath a fixed distance equal to a predetermined multiple of the length of each prosthesis.

61. An apparatus as in claim 57, wherein the first actuator is movable through a fixed distance, and each actuation of the first actuator through the fixed distance retracts the outer sheath a distance equal to the length of one prosthetic segment or a predetermined multiple thereof.

62. An apparatus as in claim 57, wherein the control mechanism comprises a plurality of axially movable sliders, the sliders being movable through a fixed distance.

63. An apparatus as in claim 62, wherein a first of the sliders is movable through a first fixed distance and a second of the sliders is movable through a second fixed distance different than the first fixed distance.

64. An apparatus as in claim 63, wherein the first slider is moved through the first fixed distance the selected number of prostheses exposed outside the sheath is a different number than when the second slider is moved through the second fixed distance.

65. An apparatus as in claim 57, further comprising a handle coupled to the proximal end of the elongated flexible member.

66. An apparatus as in claim 65, wherein the handle is adapted to be held by an operator using one hand while simultaneously actuating the first actuator or the second actuator with the fingers or thumb of the one hand.

67. An apparatus as in claim 57, wherein the first actuator comprises an axially movable slider.

68. An apparatus as in claim 57, wherein the first actuator comprises a pair of triggers.

69. An apparatus as in claim 57, wherein the first actuator comprises a lever.

70. An apparatus as in claim 57, wherein the first actuator comprises a selectable switch.

71. An apparatus as in claim 57, wherein the first actuator comprises a ratchet mechanism.

72. An apparatus as in claim 57, wherein the first actuator comprises a rotationally movable mechanism.

73. An apparatus as in claim 57, wherein the first actuator comprises a linearly movable mechanism.

74. An apparatus as in claim 57, wherein the first actuator is adapted to provide audible, visual or tactile feedback during actuation of the first actuator, to indicate the number of prostheses in the selected number.

75. An apparatus as in claim 57, wherein each actuation of the first actuator retracts the outer sheath a distance equal to the length of one of the prostheses.

76. An apparatus as in claim 57, wherein the second actuator comprises an axially movable slider.

77. An apparatus as in claim 57, wherein the second actuator comprises a lever.

78. An apparatus as in claim 57, wherein the second actuator comprises a rotationally movable mechanism.

79. An apparatus as in claim 57, wherein the second actuator comprises a linearly movable mechanism.

80. An apparatus as in claim 57, wherein the second actuator is movable through a predetermined distance and wherein moving the second actuator through the predetermined distance creates the spacing with a predetermined length.

81. An apparatus as in claim 80, wherein the second actuator is not movable beyond the predetermined distance.

82. An apparatus as in claim 80, wherein the second control provides feedback to the operator when moved through the predetermined distance.

83. An apparatus as in claim 82, wherein the feedback comprises a visual indicator associated with the second actuator.

84. An apparatus as in claim 82, wherein the feedback comprises a detent engaged by the second actuator.

85. An apparatus as in claim 80, wherein after moving through the fixed distance the second actuator is further movable to adjust the length of the spacing.

86. An apparatus as in claim 57, further comprising a pusher element disposed on the elongated flexible member and adapted to prevent the prostheses from axially moving toward the proximal end of the elongated flexible member.

87. An apparatus as in claim 57, further comprising an engaging member disposed near a distal end of the outer sheath and adapted to engage one or more of the prostheses so as to facilitate movement of the prostheses axially on the elongated flexible member.

88. An apparatus as in claim 57, wherein the prostheses are balloon expandable.

89. An apparatus as in claim 57, wherein the prostheses segments are self-expanding.

90. An apparatus as in claim 57, further comprising an expandable member coupled to the flexible member, wherein the prostheses are positionable on the expandable member for expansion therewith.

91. An apparatus as in claim 90, wherein the expandable member is a balloon.

92. An apparatus as in claim 90, wherein the sheath is adapted to constrain the expandable member from expansion when positioned over the expandable member.

93. An apparatus as in claim 92, wherein upon retraction of the sheath a selected portion of the expandable member is exposed for expansion of the selected number of prostheses.

94. An apparatus as in claim 57, wherein the plurality of prostheses carry a therapeutic agent adapted to be released therefrom.

95. An apparatus as in claim 94, wherein the therapeutic agent comprises an anti-restenosis agent.

96. An apparatus as in claim 57, wherein the plurality of prostheses have a length in the range from about 2 mm to about 20 mm.

97. An apparatus as in claim 57, wherein the plurality of prostheses have a length about 3 mm to about 10 mm.

98. An apparatus as in claim 57, wherein the plurality of prostheses have the same length.

99. An apparatus as in claim 57, wherein the plurality of prostheses have two or more lengths.

100. An apparatus as in claim 57, wherein the plurality of prostheses have ends in engagement with each other prior to deployment.

101. An apparatus as in claim 57, further comprising an indicator adapted to display the selected number of prostheses.

102. An apparatus for delivering a prosthesis in a body lumen, the apparatus comprising:

an elongated flexible member having a proximal end and a distal end;

at least a first and a second radially expandable prosthesis arranged axially along the elongated flexible member, near the distal end, the first and second prosthetic segments being in an unexpanded condition;

an outer sheath slidably disposed over at least a portion of the prostheses; and

a control mechanism coupled to the outer sheath and the elongated flexible member, wherein the control mechanism has at least two settings, wherein upon actuation of the control mechanism in the first setting the outer sheath is retracted to expose only the first prosthesis in the unexpanded condition and in the second setting the outer sheath is retracted to expose both the first and the second prostheses in the unexpanded condition.

103. An apparatus as in claim 102, wherein upon actuation of the control mechanism in the first setting the outer sheath is retracted to expose only the first prosthesis and create a preselected spacing between the first prosthesis and a distal end of the outer sheath.

104. An apparatus as in claim 103, wherein upon actuation of the control mechanism in the second setting the outer sheath is retracted to expose both the first and second prostheses and create the preselected spacing between the second prosthesis and a distal end of the outer sheath.

105. An apparatus as in claim 102, further comprising a handle adjacent to the proximal end of the elongated flexible member.

106. An apparatus as in claim 105, wherein the handle is adapted to be held by an operator using one hand while simultaneously actuating the control mechanism with the fingers or thumb of the one hand.

107. An apparatus as in claim 102, wherein the control mechanism comprises a sliding switch selectable between the two settings.

108. An apparatus as in claim 102, wherein the control mechanism comprises an axially movable actuator.

109. An apparatus as in claim 102, wherein the control mechanism comprises two axially movable sliders.

110. An apparatus as in claim 102, wherein the at least first and second prostheses are balloon expandable.

111. An apparatus as in claim 102, wherein the at least first and second prostheses are self-expanding.

112. An apparatus as in claim 102, further comprising an expandable member near the distal end of the elongated flexible member.

113. An apparatus as in claim 112, wherein the expandable member is a balloon.

114. An apparatus as in claim 102, wherein the at least first and second prostheses carry a therapeutic agent adapted to be released therefrom.

115. An apparatus as in claim 114, wherein the therapeutic agent comprises an anti-restenosis agent.

116. An apparatus as in claim 102, wherein the at least first and second prostheses have a length in the range from about 2 mm to about 20 mm

117. An apparatus as in claim 102, wherein the at least first and second prostheses have different lengths.

118. An apparatus as in claim 102, wherein the at least first and second prostheses have ends in engagement with each other prior to deployment.

119. An apparatus as in claim 102, further comprising a pusher element disposed on the elongated flexible member and adapted to prevent the at least first and second prostheses from axially moving toward the proximal end of the elongated flexible member.

120. An apparatus as in claim 102, further comprising an engaging member disposed near a distal end of the outer sheath and adapted to engage one or more of the prostheses so as to facilitate movement of the prostheses axially on the elongated flexible member.

121. An apparatus as in claim 120, wherein the engaging member is disposed a distance from a distal end of the sheath selected so that the engaging member engages only the second prosthesis when the sheath is positioned over both of the prostheses.

122. An apparatus as in claim 121, wherein the distance is greater than the length of the first prosthesis.

123. An apparatus as in claim 102, wherein the control mechanism is operatively coupled with the outer sheath.

124. An apparatus as in claim 102, wherein the control mechanism is operatively coupled with the pusher element.

125. An apparatus as in claim 102, wherein the pusher element is operatively coupled with the outer sheath.

126. An apparatus as in claim 125, wherein the control mechanism comprises an actuator for selectively coupling the pusher element to the outer sheath, the actuator having a first position in which the pusher element is retractable with the sheath, and a second position in which the pusher element remains stationary as the sheath is retracted.

127. An apparatus as in claim 125, wherein the pusher element comprises a pin slidably disposed in a slot in the outer sheath

128. A method for delivering prostheses to a body lumen, the method comprising:

positioning an elongated flexible member at a first treatment site having a first lesion length, the elongated flexible member having a plurality of prostheses axially arranged thereon and covered by an outer sheath;

selecting a length setting from a plurality of length settings on a control mechanism disposed on the elongated flexible member, the length setting corresponding to a first group of prostheses for deployment;

actuating the control mechanism disposed on the elongated flexible member so as to retract the outer sheath a predetermined distance based on the length setting so that the first group of prostheses are unconstrained from expansion;

separating the first group of prostheses from any remaining prostheses; and

deploying the first group of prostheses at the site of the lesion.

129. A method as in claim 128, wherein selecting a length comprises linearly moving an actuator.

130. A method as in claim 128, wherein selecting a length comprises rotationally moving an actuator.

131. A method as in claim 128, wherein selecting a length comprises actuating a pair of triggers pivotably coupled to a handle.

132. A method as in claim 128, wherein selecting a length comprises actuating a lever.

133. A method as in claim 128, wherein selecting a length comprises actuating a switch.

134. A method as in claim 128, wherein deploying the first group comprises radially expanding an expandable member disposed on the elongate flexible member.

135. A method as in claim 134, wherein the expandable member is a balloon.

136. A method as in claim 128, wherein the plurality of prostheses carry a therapeutic agent adapted to be released therefrom.

137. A method as in claim 136, wherein the therapeutic agent comprises an anti-restenosis agent.

138. A method as in claim 128, wherein the plurality of prostheses have ends in engagement with each other prior to deployment.

139. A method as in claim 128, wherein actuating the control mechanism comprises actuating the control mechanism with a thumb or finger.

140. A method as in claim 128, wherein separating the first group comprises actuating the control mechanism so as to create a space free of the prostheses between a proximal prosthesis in the first group and a distal end of the outer sheath with the prostheses in the unexpanded condition.

141. A method as in claim 140, wherein actuating the control mechanism creates the space with a predetermined length.

142. A method as in claim 141, wherein separating the first group further comprises adjusting the length of the space by actuating the control mechanism after creating the space with the predetermined length.

143. A method as in claim 128, wherein actuating the control mechanism comprises moving the actuator through a fixed distance thereby retracting the outer sheath a distance equal to the length of one prosthesis or a predetermined multiple thereof.

144. A method as in claim 141, wherein actuating the control mechanism comprises moving the actuator through a fixed distance thereby retracting the outer sheath a distance equal to the length of one prosthesis or a predetermined multiple thereof plus the space.

145. A method as in claim 128, wherein selecting a length setting comprises adjusting the position of a selector switch having a plurality of positions corresponding to different numbers of the prostheses to be included in the first group.

146. A method as in claim 128, wherein selecting a length comprises adjusting at least one of a plurality of axially movable sliders, the sliders being movable through a fixed distance.

147. A method as in claim 146, wherein a first of the sliders is movable through a first fixed distance and a second of the sliders is movable through a second fixed distance different than the first distance.

148. A method as in claim 147, wherein moving the first slider through the first fixed distance exposes a number of prostheses outside the sheath different than when moving the slider through the second fixed distance.

149. A method as in claim 128, wherein selecting a length setting comprises providing feedback to an operator, the feedback indicating the selected length.

150. A method as in claim 149, wherein the feedback comprises a visual indicator.

151. A method as in claim 149, wherein the feedback comprises a detent engaged by the control mechanism.

152. A method as in claim 128, wherein actuating the control mechanism further comprises preventing the prostheses from axially moving toward the proximal end of the elongated flexible member.

153. A method for delivering prostheses to a body lumen, the method comprising:

positioning an elongated flexible member at a first treatment site having a first lesion length, the elongated flexible member having at least a first and a second prosthesis axially arranged thereon and covered by an outer sheath;

selecting a length setting from at least two length settings on a control mechanism disposed on the elongated flexible member, the length setting corresponding to a number of prostheses for deployment;

actuating the control mechanism wherein actuating the control mechanism in the first setting retracts the outer sheath to expose only the first prosthesis and create a pre-selected spacing between the first prosthesis and the second prosthesis, and wherein actuating the control mechanism in the second setting retracts the outer sheath to expose both the first and the second prostheses and create a pre-selected spacing between the second prosthesis and a distal end of the outer sheath; and

deploying the number of prostheses at the site of the lesion.

154. A method as in claim 153, wherein actuating the control mechanism comprises actuating the control mechanism with a thumb or finger.

155. A method as in claim 153, wherein selecting a length setting comprises adjusting the position of a selector switch having a plurality of positions corresponding to different numbers of the prostheses to be included in the first group.

156. A method as in claim 153, wherein selecting a length comprises adjusting at least one of a plurality of axially movable sliders, the sliders being movable through a fixed distance.

157. A method as in claim 153, wherein selecting a length setting comprises providing feedback to an operator, the feedback indicating the selected length.

158. A method as in claim 157, wherein the feedback comprises a visual indicator.

159. A method as in claim 157, wherein the feedback comprises a detent engaged by the control mechanism.

160. A method as in claim 153, wherein actuating the control mechanism further comprises preventing the prostheses from axially moving toward the proximal end of the elongated flexible member.

161. A method as in claim 153, wherein actuating the control mechanism comprises linearly moving the control mechanism.

162. A method as in claim 153, wherein selecting a length comprises linearly moving an actuator.

163. A method as in claim 153, wherein selecting a length comprises actuating a switch.

164. A method as in claim 153, wherein selecting a length comprises moving an actuator with a thumb.

165. A method as in claim 153, wherein selecting a length comprises moving an actuator with a finger or thumb.

166. A method as in claim 153, wherein actuating the control mechanism comprises moving the control mechanism with a finger or thumb.

167. A method as in claim 153, wherein deploying the number of prostheses comprises radially expanding an expandable member disposed on the elongate flexible member.

168. A method as in claim 167, wherein the expandable member is a balloon.

169. A method as in claim 153, wherein the at least first and second prostheses carry a therapeutic agent adapted to be released therefrom.

170. A method as in claim 169, wherein the therapeutic agent comprises an anti-restenosis agent.

171. A method as in claim 153, wherein the at least first and second prostheses have ends in engagement with each other prior to deployment.