System and method for optimized delivery of an aerosol to the respiratory tract
First Claim
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1. A system for delivery of an aerosolized formulation to the respiratory tract of a host, comprising:
- an inspiration sensor operative to perform one or more of the following functions;
detect an initiation of respiration, detect a cessation of inspiration, detect a flow rate, and calculate a volume of a gas flowing past the inspiration sensor;
an aerosol generator operative to aerosolize and release a formulation to be delivered to the respiratory tract of the human or animal;
a computer system including an aerosol controller system and in communication with the inspiration sensor and the aerosol generator and operative to perform the following functions;
i. receive information from the inspiration sensor;
ii. process information received from the inspiration sensor and determine at least one respiration parameter;
iii. determine the desired time during a respiration cycle for initiation and cessation of aerosol release based upon one or more respiration parameters and on one or more delivery parameters, wherein the delivery parameters include inputted delivery parameters and calculated delivery parameters, and wherein the computer system determines calculated delivery parameters based on one or more respiration parameters and optionally one or more inputted delivery parameters;
iv. communicate with the aerosol generator to activate and terminate the release of aerosolized formulation;
v. repeat steps i through iv and automatically adjust for any changes in the respiration parameters or delivery parameters; and
vi. repeat i through v until a desired amount of formulation has been delivered.
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Abstract
The present disclosure relates to systems, methods, and devices for controlling delivery of aerosolized formulations to patients in need of treatment, which optimizes aerosol deposition to the respiratory tract of the patient and can be adapted for use in spontaneously breathing patients or in those requiring mechanical ventilation.
181 Citations
45 Claims
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1. A system for delivery of an aerosolized formulation to the respiratory tract of a host, comprising:
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an inspiration sensor operative to perform one or more of the following functions;
detect an initiation of respiration, detect a cessation of inspiration, detect a flow rate, and calculate a volume of a gas flowing past the inspiration sensor;
an aerosol generator operative to aerosolize and release a formulation to be delivered to the respiratory tract of the human or animal;
a computer system including an aerosol controller system and in communication with the inspiration sensor and the aerosol generator and operative to perform the following functions;
i. receive information from the inspiration sensor;
ii. process information received from the inspiration sensor and determine at least one respiration parameter;
iii. determine the desired time during a respiration cycle for initiation and cessation of aerosol release based upon one or more respiration parameters and on one or more delivery parameters, wherein the delivery parameters include inputted delivery parameters and calculated delivery parameters, and wherein the computer system determines calculated delivery parameters based on one or more respiration parameters and optionally one or more inputted delivery parameters;
iv. communicate with the aerosol generator to activate and terminate the release of aerosolized formulation;
v. repeat steps i through iv and automatically adjust for any changes in the respiration parameters or delivery parameters; and
vi. repeat i through v until a desired amount of formulation has been delivered. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A system for delivery of an aerosolized formulation to the respiratory tract of a ventilated host, comprising:
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a ventilator, to which the ventilated host is attached;
an inspiration sensor in communication with an inspiratory pathway of the ventilator and operative to perform one or more of the following functions;
detect an initiation of respiration, detect a cessation of inspiration, detect a flow rate, and calculate a volume of a gas flowing past the inspiration sensor;
an aerosol generator operative to aerosolize and release a formulation to be delivered to the respiratory tract of the host, wherein said aerosol generator is in communication with the inspiratory pathway of the ventilator to allow release of the aerosolized formulation from the aerosol generator into the inspiratory pathway;
a waste sensor in communication with an expiratory pathway of the ventilator operative to detect an amount of exhaled waste;
a computer system in communication with the inspiration sensor, waste sensor, and the aerosol generator operative to perform the following functions;
i. receive information from the inspiration sensor and the waste sensor;
ii. process information received from the inspiration sensor and determine at least one respiration parameter;
iii. process information received from the waste sensor and determine a waste percentage;
iv. determine a desired time during a respiration cycle for initiation and cessation of aerosol release based upon one or more respiration parameters and on one or more delivery parameters, wherein the delivery parameters include inputted delivery parameters and calculated delivery parameters, and wherein the computer system determines calculated delivery parameters based on one or more respiration parameters and optionally one or more inputted delivery parameters and optionally the waste percentage;
v. communicate with the aerosol generator to activate and terminate the release of aerosolized formulation;
vii. repeat steps i through v and automatically adjust for any changes in the respiration parameters or delivery parameters; and
viii. repeat steps i through vii until a desired amount of formulation has been delivered.
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27. A method for optimizing delivery of an aerosolized formulation to the respiratory tract of a human or animal, comprising:
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a. detecting respiration data;
b. determining respiration parameters from respiration data;
c. determining calculated delivery parameters from respiration data and one or more inputted delivery parameters;
d. determining the desired time during a respiration cycle for initiation and cessation of aerosol release based upon one or more respiration parameters and on one or more calculated delivery parameters;
e. communicating with an aerosol generator to activate and terminate the release of aerosolized formulation;
f. repeating steps a through e and adjusting for any changes in the respiration parameters or delivery parameters; and
g. repeating a through f until a desired amount of formulation has been delivered. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A method for optimizing delivery of an aerosolized formulation to the respiratory tract of a human or animal, comprising:
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a. acquiring inputted delivery parameters, wherein inputted delivery parameters are selected from one or more of the following parameters;
a patient-specific parameter, a formulation-specific parameter, an airway connection-specific parameter, an estimated start and stop time for aerosol generation, a specified length of time to complete delivery of a desired volume of formulation, and a delivery efficiency setting;
b. determining calculated delivery parameters from one or more inputted delivery parameters;
c. determining the desired time during a respiration cycle for initiation and cessation of aerosol release based upon one or more calculated delivery parameters;
d. communicating with an aerosol generator to activate and terminate the release of aerosolized formulation;
e. detecting an amount of waste selected from wrap-around waste and exhaled waste;
f. adjusting calculated delivery parameters with respect to the amount of waste detected;
g. repeating steps a through f and automatically adjusting for any changes in the amount of waste detected or the delivery parameters; and
h. repeating a through g until a desired amount of formulation has been delivered. - View Dependent Claims (43, 44, 45)
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42. A system comprising:
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an aerosol controller logic configured to;
determine a desired time during a respiration cycle for initiation and cessation of aerosol generation based upon one or more calculated delivery parameters calculated from one or more respiration parameters and one or more inputted delivery parameters, and optionally a waste percentage; and
automatically adjust the desired time for initiation and cessation of aerosol generation based upon any changes in calculated delivery parameters.
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Specification