METHOD FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A LIQUID SAMPLE USING SMALL VOLUME SAMPLES AND FAST TEST TIMES
First Claim
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1. A method of determining the concentration of an analyte in a liquid sample comprising:
- providing a test sensor including a sample receiving cavity having a volume of less than about 1.5 μ
l, the sensor including at least one working electrode and at least one counter electrode disposed within the sample receiving cavity, the sensor further including a reagent layer comprising an enzyme and a mediator, the reagent layer being disposed on at least the working electrode, at least one of the enzyme and mediator being selected to react with the analyte to generate an electrochemical signal representative of the concentration of the analyte in the liquid sample;
admitting the liquid sample into the sample receiving cavity;
detecting the time at which the liquid sample enters the sample cavity;
following said detecting, controlling the voltage or current across the working and counter electrodes; and
within ten seconds of said detecting, obtaining a readout of the concentration of the analyte in the liquid sample.
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Abstract
Analytes in a liquid sample are determined by methods utilizing sample volumes of less than about 1.5 μl and test times within ten seconds. The methods are preferably performed using small test strips including a sample receiving chamber filled with the sample by capillary action.
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Citations
14 Claims
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1. A method of determining the concentration of an analyte in a liquid sample comprising:
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providing a test sensor including a sample receiving cavity having a volume of less than about 1.5 μ
l, the sensor including at least one working electrode and at least one counter electrode disposed within the sample receiving cavity, the sensor further including a reagent layer comprising an enzyme and a mediator, the reagent layer being disposed on at least the working electrode, at least one of the enzyme and mediator being selected to react with the analyte to generate an electrochemical signal representative of the concentration of the analyte in the liquid sample;
admitting the liquid sample into the sample receiving cavity;
detecting the time at which the liquid sample enters the sample cavity;
following said detecting, controlling the voltage or current across the working and counter electrodes; and
within ten seconds of said detecting, obtaining a readout of the concentration of the analyte in the liquid sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification