Modulation of survivin expression
2 Assignments
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Accused Products
Abstract
Compounds and compositions are provided for modulating the expression of survivin. The compounds, exemplified by those acting through an RNAi antisense mechanism of action, include double-stranded and single-stranded constructs, as well as siRNAs, canonical siRNAs, blunt-ended siRNAs and single-stranded antisense RNA compounds. Methods of using these compounds for modulation of survivin expression and for treatment of diseases associated with expression of survivin are provided.
26 Citations
96 Claims
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1-71. -71. (canceled)
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72. A compound comprising a chemically modified or unmodified double-stranded nucleic acid compound that is 19-23 nucleobases in length,
wherein a first strand has at least 19 contiguous nucleobases of a polynucleotide selected from the group consisting of SEQ ID NOs: - 17, 23, 25, 27, 29, 31, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 59, 61, 65, 67, 69, 73, and 81,
and wherein a second strand is 100% complementary to the first strand. - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96)
- 17, 23, 25, 27, 29, 31, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 59, 61, 65, 67, 69, 73, and 81,
Specification