Method, apparatus, surgical technique, and stimulation parameters for autonomic neuromodulation for the treatment of obesity

• US 20070162085A1
• Filed: 03/09/2007
• Published: 07/12/2007
• Est. Priority Date: 07/23/2001
• Status: Abandoned Application

• Current Assignee: DiLorenzo Biomedical, LLC
• Original Assignee: DiLorenzo Biomedical, LLC
• Inventors: DiLorenzo, Daniel
• Application Number:
  US11/716,451
• Publication Number:
  US 20070162085A1
• Time in Patent Office: Days
• US Class Current: 607/40
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

The present invention teaches a method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.

Claims

1. An apparatus for use controlling weight in an organism by modulating the sympathetic nervous system comprising:

A. a pulse generator;

B. a neuromodulator, which modulates the activity of a portion of the sympathetic nervous system, to control weight of said organism;

C. a connector, providing connection between said pulse generator and said neuromodulator.

2. The apparatus of claim 1 wherein modulation of activity of a portion of the sympathetic nervous system influences metabolism.

3. The apparatus of claim 1 wherein modulation of activity of a portion of the sympathetic nervous system influences satiety.

4. The apparatus of claim 1 wherein modulation of activity of a portion of the sympathetic nervous system influences appetite.

5. The apparatus of claim 1 wherein said modulator is implanted using minimally invasive technique.

6. The apparatus of claim 1 wherein said modulator is noninvasive.

7. An apparatus for modulating the autonomic index in an organism comprising:

A. a pulse generator;

B. a neuromodulator, designed to modulate fibers of the sympathetic nervous system, to control weight of said organism;

C. a connector, providing connection between said pulse generator and said neuromodulator.

8. The apparatus of claim 7, wherein said neuromodulator modulates fibers of the sympathetic nervous system to control weight of said organism.

9. The apparatus of claim 7, wherein said neuromodulator modulates fibers of the sympathetic nervous system to reduce weight of said organism.

10. The apparatus of claim 7, wherein said neuromodulator modulates fibers of the sympathetic nervous system to treat obesity in said organism.

11. The apparatus of claim 7, wherein said neuromodulator is an electrode catheter.

12. A method for controlling weight in an organism comprising:

A. placing a neuromodulator in communication with a component of the sympathetic nervous system;

B. delivering a neuromodulation signal to said component of the sympathetic nervous system to influence the weight of said organism.

13. The method of claim 12 further comprising identifying a patient whose weight is larger than desired.

14. The method of claim 12, wherein said organism is a patient whose weight is larger than desired.

15. The method of claim 12 further comprising identifying a patient who is obese.

16. The method of claim 12, wherein said organism is an obese patient.

17. The method of claim 12 wherein placing of a neuromodulator is performed in a minimally invasive manner.

18. The method of claim 12 wherein placing of a neuromodulator is performed in a noninvasive manner.

19. The method of claim 12 wherein said neuromodulation signal increases activity of a portion of the sympathetic nervous system.

20. The method of claim 12 wherein said neuromodulation signal decreases activity of a portion of the sympathetic nervous system.

21. The method of claim 12 wherein said neuromodulation signal increases metabolic rate.

22. The method of claim 12 wherein said neuromodulation signal induces satiety.

23. The method of claim 12 wherein said neuromodulation signal reduced appetite.

24. The method of claim 12 wherein said neuromodulation signal causes weight loss in said organism.

25. The method of claim 12 wherein said neuromodulation signal causes weight gain in said organism.