Bandage For Facilitating Transdermal Respiration And Healing

• US 20070166357A1
• Filed: 04/06/2006
• Published: 07/19/2007
• Est. Priority Date: 01/16/2006
• Status: Active Grant

• Current Assignee: Peach Technologies, LLC
• Original Assignee: Peach Technologies, LLC
• Inventors: Shaffer, Thomas, Wolfson, Marla, Stern, Robert
• Granted Patent: US 9,017,717 B2
• Time in Patent Office: Days
• US Class Current: 424/443
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 2013/00246 in a special way pervious to air or vapours
• CPC Class Codes: A61F 2013/00855 pervious to air or vapours
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
• CPC Class Codes: A61L 15/20 containing organic materials
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/10 containing or releasing inorganic materials
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow

Abstract

A bandage includes a reservoir filled with a perfluorochemical fluid, saturated with oxygen. Oxygen passes through a permeable membrane to the skin or wound to promote healing, and carbon dioxide travels from the skin or wound to the reservoir.

Claims

1. A bandage comprising a reservoir containing perfluorochemical fluid, the reservoir being sealed by a gas-permeable membrane.

2. A bandage according to claim 1 wherein the perfluorochemical fluid has at least one gaseous material dissolved therein.

3. A bandage according to claim 1 wherein the perfluorochemical fluid contains less than a predetermined amount of carbon dioxide dissolved in the perfluorochemical fluid, the predetermined amount of carbon dioxide dissolved in the perfluorochemical fluid having a partial pressure of 45 mm Hg.

4. A bandage according to claim 2 wherein the gas-permeability of the membrane increases as a function of temperature.

5. A bandage according to claim 2 wherein the gaseous material is oxygen.

6. A bandage according to claim 5 further comprising an oxygen-impermeable cover, the reservoir being sealed between the cover and the membrane.

7. A bandage according to claim 1 wherein the perfluorochemical fluid is selected from the group consisting of C₄F₉CH═

CH₄C₉, i-C₃F₉CH═

CHC₆F₁₃, C₆F₁₃CH═

CHC₆F₁₃, C,₁₀F,₁₈, C₈F₁₇Br, (C₆F₁₃)₂O, CF₃CFOCF₂CF₃, (CF₃)₂CFO(CF₂)₃(CF₃)₂CFO(CF₂)₄OCF(CF₃)₂, (CF₃)₂CFO(CF₂)₆OCF(CF₃)₂, F-2-butyltetrahydrofuran,F-n-cyclohexylpyrrolidine, F-n-methyldecahydroquinoline, F-n-methyldecahydroisoquinoline, F-adamantane, F-methyladamantane, F-1,3-dimethyladamantane, F-dimethylbicyclo[3,3,1]nonane, F-trimethylb icyclo[3,3,1]nonane, F-tripropylamine, F-tributylamine, C-4alkyl decalins C₁₄F₂₄/C₁₄F₂₆, C₁₀F₁₈, C₈F₁₇Br,C₆F₁₄-perfluorohexanes, FC-77, and mixtures thereof.

8. A bandage according to claim 1 wherein the perfluorochemical fluid comprises at least one fluorinated hydrocarbon having at least one-half of the corresponding hydrocarbon'"'"'s hydrogen atoms substituted by fluorine.

9. A bandage according to claim 5 further comprising dissolving other therapeutic gases in the perfluorochemical fluid to enhance the oxygenation of the perfluorochemical fluid.

10. A bandage according to claim 9 wherein other gases are selected from the group consisting of helium and nitric oxide.

11. A treatment process comprising:

(a) applying to the skin of an animal a bandage comprising a reservoir containing perfluorochemical fluid, the reservoir being sealed by a gas-permeable membrane, and

(b) maintaining contact between the bandage and the skin for a predetermined period of time.

12. A treatment process according to claim 11 wherein the bandage comprises a removable seal covering the membrane, and additionally comprising removing the seal before applying the bandage to the skin.

13. A treatment process according to claim 11 wherein the perfluorochemical fluid has at least one gaseous material dissolved therein.

14. A treatment process according to claim 11, wherein the perfluorochemical fluid initially contains less than a predetermined amount of carbon dioxide dissolved in the perfluorochemical fluid before application of the bandage to the skin, the predetermined amount of carbon dioxide dissolved in the perfluorochemical fluid having a partial pressure of 45 mm Hg.

15. A treatment process according to claim 11 wherein the permeability of the membrane to the gaseous material increases as a function of temperature.

16. A treatment process according to claim 13 wherein the gaseous material is oxygen.

17. A treatment process according to claim 13 wherein the bandage further comprises an oxygen-impermeable cover, the reservoir being sealed between the cover and the membrane.

18. A treatment process according to claim 11 wherein the perfluorochemical fluid is selected from the group consisting of C₄F₉CH═

CH₄C₉, i-C₃F₉CH═

CHC₆F₁₃, C₆F₁₃CH═

CHC₆F₁₃, C₁₀F₁₈, C₈F₁₇Br, (C₆F₁₃₎₂O, CF₃CFOCF₂CF₃,(CF₃)₂CFO(CF₂)₃CF₃(CF₃)₂CFO(CF₂)₄OCF(CF₃)₂, (CF₃)₂CFO(CF₂)₆OCF(CF₃)₂, F-2-butyltetrahydrofuran,F-n-cyclohexylpyrrolidine, F-n-methyidecahydroquinoline, F-n-methyldecahydroisoquinoline, F-adamantane, F-methyladamantane, F-1,3-dimethyladamantane, F-dimethylbicyclo[3,3,1]nonane, F-trimethylbicyclo[3,3,1]nonane, F-tripropylamine, F-tributylamine, C-4 alkyl decalins C₁₄F₂₄/C₁₄F₂₆, C,₁₀F₁₈, C₈F₁₇Br, C₆F₁₄-perfluorohexanes, FC-77, and mixtures thereof.

19. A treatment process according to claim 13 further comprising dissolving other therapeutic gases in the perfluorochemical fluid to enhance the oxygenation of the perfluorochemical fluid.

20. A treatment process according to claim 19 wherein other gases are selected from the group consisting of helium and nitric oxide.