Transabdominal examination, monitoring and imaging of tissue
First Claim
1. An optical method for in vivo, non-invasive, transabdominal examination of fetal tissue comprising:
- providing an optical module including an array of optical input ports and detection ports located in a selected geometrical pattern that provide a multiplicity of photon migration paths inside the uterus of a pregnant female subject;
placing said optical module on the exterior of the abdomen of the pregnant female subject based on locating a fetus by an ultrasound system;
emitting visible or infrared light from a light source and introducing said emitted light at least one said optical input port into the uterus and receiving photons that have migrated in the uterus to at least one of said detection ports;
detecting said received photons by at least one optical detector optically coupled to said least one detection port;
controlling said introducing and detecting steps to collect optical data corresponding to photons of light that have partially migrated inside a fetal tissue region; and
processing said optical data to characterize the fetal tissue region.
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Accused Products
Abstract
An optical examination technique employs an optical system (15, 45, 100, 150, 200, 260 or 300) for in vivo, non-invasive examination of internal tissue of a subject. The optical system includes an optical module (12 or 14), a controller and a processor. The optical module is arranged for placement on the exterior of the abdomen or chest. The module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths targeted to examine a selected tissue region, such as an internal organ or an in utero fetus. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths. The processor receives signals corresponding to the detected light and forms at least one data set used for tissue examination.
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Citations
31 Claims
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1. An optical method for in vivo, non-invasive, transabdominal examination of fetal tissue comprising:
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providing an optical module including an array of optical input ports and detection ports located in a selected geometrical pattern that provide a multiplicity of photon migration paths inside the uterus of a pregnant female subject;
placing said optical module on the exterior of the abdomen of the pregnant female subject based on locating a fetus by an ultrasound system;
emitting visible or infrared light from a light source and introducing said emitted light at least one said optical input port into the uterus and receiving photons that have migrated in the uterus to at least one of said detection ports;
detecting said received photons by at least one optical detector optically coupled to said least one detection port;
controlling said introducing and detecting steps to collect optical data corresponding to photons of light that have partially migrated inside a fetal tissue region; and
processing said optical data to characterize the fetal tissue region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An optical apparatus for in vivo, non-invasive, transabdominal examination of fetal tissue comprising:
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a light source and a light detector;
an optical module including an array of optical input ports and detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths providing an optical field inside a uterus of a female subject, each said optical input port being constructed to introduce visible or infrared light emitted from said light source, each said optical detection port being constructed to receive photons of light that have migrated from at least one of said input ports and provide said received light to said light detector;
said optical module being positionable on an exterior surface of a female subject and constructed to provide direction of said optical field based on a prior ultrasound scan;
a controller constructed and arranged to control operation of said light source and said light detector to detect photons that have migrated over at least one of said photon migration paths inside fetal tissue; and
a processor connected to receive signals from said detector and arranged to characterize the fetal tissue region. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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22. An optical system for in vivo, non-invasive examination of internal tissue of a subject comprising:
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an optical module including an array of optical input ports and detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside an examined region of the biological tissue, each said optical input port being constructed to introduce visible or infrared light emitted from a light source, each said optical detection port being constructed to receive photons of light that have migrated in the examined tissue region from at least one of said input ports and provide said received light to a light detector;
a controller constructed and arranged to control operation of said light source and said light detector to detect light that has migrated over at least one of said photon migration paths; and
a processor connected to receive signals from said detector and arranged to form at least two data sets, a first of said data sets representing blood volume in the examined tissue region and a second of said data sets representing blood oxygenation in the examined tissue region;
said processor being arranged to correlate said first and second data sets to detect abnormal tissue in the examined tissue region. - View Dependent Claims (23, 24, 27, 28, 29, 30)
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25. An optical system for in vivo, non-invasive examination of internal tissue of a subject comprising:
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an optical module including an array of optical input ports and detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside an examined region of the biological tissue, each said optical input port being constructed to introduce visible or infrared light emitted from a light source, each said optical detection port being constructed to receive photons of light that have migrated in the tissue from at least one of said input ports and provide said received light to a light detector;
a controller constructed and arranged to control operation of said light source and said light detector to detect light that has migrated over at least one of said photon migration paths; and
a processor connected to receive signals from said detector and arranged to form at least two data sets, a first of said data sets being collected by irradiating an examined tissue region of interest and a second of said data sets being collected by irradiating a reference tissue region having similar light scattering and absorptive properties as the examined tissue region, said processor being arranged to correlate said first and second data sets to detect abnormal tissue in the examined tissue region.
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26. An optical system for in vivo, non-invasive examination of internal tissue of a subject comprising:
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an optical module including an array of optical input ports and detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside an examined region of the biological tissue or a model representing biological tissue, each said optical input port being constructed to introduce visible or infrared light emitted from a light source, each said optical detection port being constructed to receive photons of light that have migrated in the tissue or the model from at least one of said input ports and provide said received light to a light detector;
a controller constructed and arranged to control operation of said light source and said light detector to detect light that has migrated over at least one of said photon migration paths; and
a processor connected to receive signals from said detector and arranged to form at least two data sets of two tissue regions, a first of said data sets being collected by irradiating an examined tissue region and a second of said data sets being collected by irradiating a region of a tissue model having selected light scattering and absorptive properties, said processor being arranged to correlate said first and second data sets to detect abnormal tissue in the examined tissue region.
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31-43. -43. (canceled)
Specification