System and method for monitoring health using exhaled breath
First Claim
1. A method for monitoring endogenous compounds in a patient, comprising:
- sampling a patient'"'"'s expired breath;
analyzing the breath concentration of at least one endogenous compound marker using sensor technology, wherein the concentration of the at least one endogenous compound marker is proportionate to a corresponding concentration of at least one endogenous compound in the patient;
calculating the concentration of the endogenous compound marker in the patient'"'"'s breath; and
based on the calculated concentration of the endogenous compound marker in the patient'"'"'s breath, calculating the corresponding concentration of the endogenous compound in the patient.
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Abstract
The present invention includes systems and methods for monitoring endogenous compound concentration in blood by detecting markers, such as odors, upon exhalation by a patient, wherein such markers are the endogenous compound itself or result from the endogenous compound. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor endogenous compound levels in blood. The invention further includes a reporting system capable of tracking endogenous compound concentrations in blood (remote or proximate locations) and providing the necessary alerts with regard to emergent or harmful conditions in a patient.
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Citations
96 Claims
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1. A method for monitoring endogenous compounds in a patient, comprising:
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sampling a patient'"'"'s expired breath;
analyzing the breath concentration of at least one endogenous compound marker using sensor technology, wherein the concentration of the at least one endogenous compound marker is proportionate to a corresponding concentration of at least one endogenous compound in the patient;
calculating the concentration of the endogenous compound marker in the patient'"'"'s breath; and
based on the calculated concentration of the endogenous compound marker in the patient'"'"'s breath, calculating the corresponding concentration of the endogenous compound in the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 77, 78, 79, 80)
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20. An endogenous compound monitoring system comprising:
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a means for collecting a sample of a patient'"'"'s breath;
a sensor technology for analyzing the breath concentration of at least one endogenous compound marker, wherein the concentration of the at least one endogenous compound marker is proportionate to a corresponding concentration of at least one endogenous compound in the patient, wherein the sensor technology generates a signal regarding the analyzed concentration; and
a processor connected to the sensor technology, which receives and analyzes the signal from the sensor to calculate and communicate the corresponding concentration of the endogenous compound in the patient based on the concentration of the endogenous compound marker in the patient'"'"'s breath. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 81, 82, 83, 84)
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36. An anesthetic agent delivery system for delivering a desired dose of anesthetic agent to a patient comprising:
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an anesthetic supply having a controller for controlling the amount of anesthetic agent provided by the supply;
a breath analyzer for analyzing the patient'"'"'s breath for concentration of at least one substance indicative of the anesthetic agent concentration in the patient'"'"'s bloodstream that provides a signal to indicate the anesthetic agent concentration delivered to the patient; and
a system controller connected to the anesthetic supply which receives the signal and controls the amount of anesthetic agent based on the signal. - View Dependent Claims (37, 38, 85, 86, 87, 88)
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39. An anesthetic agent delivery and monitoring system for delivering balanced anesthesia to a patient through a breathing circuit and an IV comprising:
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an anesthetic gas supply having a controller for controlling the amount of volatile anesthetic agent provided by the supply to the breathing circuit;
an intravenous anesthetic agent supply having a controller for controlling the amount of IV anesthetic agent administered to the patient intravenously;
an inspired gas analyzer for analyzing the concentration of anesthetic gas in the breathing circuit;
an expired gas analyzer for analyzing the patient'"'"'s breath for concentration of at least one substance indicative of anesthetic agent concentrations in the patient'"'"'s bloodstream that provides at least one signal to indicate the anesthetic agent concentration delivered to the patient; and
a system controller connected to each of the anesthetic supplies which receives the signal and controls the amount of anesthetic agents administered based on the signal. - View Dependent Claims (40, 41, 89, 90, 91, 92)
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42. An apparatus for administering balanced anesthesia to a patient comprising:
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at least one supply of at least one intravenous anesthetic agent;
intravenous delivery means for controllably intravenously delivering said at least one intravenous anesthetic agent to the patent;
at least one supply of at least one inhalational anesthetic agent;
a breathing circuit for delivery of said inhalational anesthetic agent;
all inspired gas analyzer for analyzing gas in said breathing circuit for said inhalational agent;
an expired gas analyzer for analyzing the patient'"'"'s breath for concentration of at least one substance indicative of anesthetic agents in the patient'"'"'s bloodstream that provides a signal to indicate anesthetic agent concentration delivered to the patient;
a system controller connected to the intravenous delivery means which receives the signal and controls the amount of anesthetic agent based on the signal; and
a system controller connected to the breathing circuit which receives the signal and controls the amount of anesthetic agent based on the signal. - View Dependent Claims (93, 94, 95, 96)
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43. A method of monitoring a patient during administration of at least one therapeutic drug, said method comprising:
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administering to the patient at least one therapeutic drug;
exposing at least one sensor to expired gases from the patient;
detecting one or more target markers from the therapeutic drug with said sensor. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 75, 76)
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72. A therapeutic drug delivery and monitoring system for delivering an appropriate dosage of the therapeutic drug to a patient:
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at least one therapeutic drug supply having a controller for controlling the amount of therapeutic drug provided by the supply to the patient;
an expired gas sensor for analyzing the patient'"'"'s breath for the presence and concentration of at least one target marker indicative of therapeutic drug concentrations in the patient'"'"'s bloodstream, and for sending a signal regarding the concentration of the therapeutic drug in the patient'"'"'s bloodstream; and
a system controller connected to the therapeutic drug supply, which receives and analyzes the signal from the sensor and controls the amount of therapeutic drug administered to the patient based on the signal. - View Dependent Claims (73, 74)
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Specification