Remotely RF powered conformable thermal applicators

• US 20070168001A1
• Filed: 11/16/2006
• Published: 07/19/2007
• Est. Priority Date: 11/17/2005
• Status: Active Grant

• Current Assignee: Intematix Corporation
• Original Assignee: Intematix Corporation
• Inventors: Wang, Gang, Yang, Haitao, Melman, Jonathan, Xiang, Xiao-Dong, Dionne, Gerald
• Granted Patent: US 7,945,335 B2
• Time in Patent Office: Days
• US Class Current: 607/101
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61K 49/1818 particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052

Abstract

Embodiments of the present invention are generally related to apparatus and methodology of thermal applicators in cancer therapy. In particular, the present embodiments are directed to a technique called “nanoparticle ferromagnetic resonance heating,” where ferromagnetic resonance heating in addition to an RF hyperthermia treatment is used to cause cell apoptosis and necrosis. An apparatus for carrying out a ferromagnetic resonance heating treatment of a tumor, comprises a volume concentration of super paramagnetic particles contained within the interior of the tumor, the concentration ranging from about 0.1 to about 1 percent; a magnetic field source configured to deliver a gradient DC magnetic field to the region of the tumor; and an energy source configured to deliver to the tumor an RF field at a frequency ranging from about 100 to 200 MHz. The apparatus of claim 1, wherein the super paramagnetic particles are selected from the group consisting of maghemite (γ-Fe₂O₃) based compounds, and yttrium iron garnet (Y₃Fe₅O₁₂) based compounds.

Claims

1. An apparatus for carrying out a ferromagnetic resonance heating treatment of a tumor, the apparatus comprising:

a volume concentration of super paramagnetic particles contained within the interior of the tumor, the concentration ranging from about 0.1 to about 1 percent;

a magnetic field source configured to deliver a gradient DC magnetic field to the region of the tumor; and

an energy source configured to deliver to the tumor an RF field at a frequency ranging from about 100 to 200 MHz.

2. The apparatus of claim 1, wherein the super paramagnetic particles are selected from the group consisting of maghemite (γ

-Fe₂O₃) based compounds, and yttrium iron garnet (Y₃Fe₅O₁₂) based compounds.