Porous three dimensional nest scaffolding
First Claim
1. A scaffold for location in a patient, the scaffold comprising:
- a substrate;
at least one nest connected to the substrate, the nest extending away from the substrate to define an enclosed volume on the substrate associated with the nest, the nest having openings that extend from an outer surface of the nest to the associated enclosed volume; and
a plurality of cells associated with the scaffold.
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Accused Products
Abstract
The invention provides porous three dimensional scaffold structures that may be used to deliver a bioactive agent, such as cells, into a location within the body. In one example form, the porous three dimensional structure may be a stent. In another example form, the porous three dimensional structure may be a microscale or nanoscale device for the delivery of the bioactive agent. The scaffold may include a substrate and one or more nests connected to the substrate. The nest(s) extend away from the substrate to define an enclosed volume on the substrate within each nest. The nests have openings that extend from an outer surface of the nest to the enclosed volume within each nest. The scaffold includes a bioactive agent disposed within the enclosed volume of at least one nest on the substrate. The bioactive agent is delivered to the patient when the scaffold is located within the patient.
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Citations
47 Claims
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1. A scaffold for location in a patient, the scaffold comprising:
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a substrate;
at least one nest connected to the substrate, the nest extending away from the substrate to define an enclosed volume on the substrate associated with the nest, the nest having openings that extend from an outer surface of the nest to the associated enclosed volume; and
a plurality of cells associated with the scaffold. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A scaffold for location in a patient, the scaffold comprising:
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a non-woven substrate;
at least one non-woven nest connected to the substrate, the nest extending away from the substrate to define an enclosed volume on the substrate associated with the nest, the nest having openings that extend from an outer surface of the nest to the associated enclosed volume; and
a bioactive agent disposed within the enclosed volume on the substrate. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A device for delivery of a bioactive agent to a vessel of a patient, the device comprising:
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a substrate;
at least one nest connected to the substrate, the nest extending away from the substrate to define an enclosed volume on the substrate associated with the nest, the nest having openings that extend from an outer surface of the nest to the associated enclosed volume; and
a bioactive agent disposed within the enclosed volume on the substrate, wherein the device is a nanoscale device. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A radially expandable lumenal scaffold comprising:
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a deformable substrate;
at least one nest connected to the substrate, the nest extending away from the substrate to define an enclosed volume on the substrate associated with the nest, the nest having openings that extend from an outer surface of the nest to the associated enclosed volume; and
a bioactive agent disposed within the enclosed volume on the substrate, wherein the substrate is wrapped about an axis to form the scaffold. - View Dependent Claims (41, 42, 43)
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44. A radially expandable lumenal scaffold comprising:
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a deformable substrate;
at least one nest connected to the substrate, the nest extending away from the substrate to define an enclosed volume on the substrate associated with the nest, the nest having openings that extend from an outer surface of the nest to the associated enclosed volume; and
a bioactive agent disposed within the enclosed volume on the substrate, wherein the substrate is folded to form the scaffold. - View Dependent Claims (45, 46, 47)
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Specification