APPARATUS, SYSTEM AND METHOD FOR TISSUE OXIMETRY

• US 20070172392A1
• Filed: 12/13/2006
• Published: 07/26/2007
• Est. Priority Date: 12/13/2005
• Status: Abandoned Application

• Current Assignee: Ohio State University
• Original Assignee: Ohio State University
• Inventors: Roy, Sashwati, Khanna, Savita, Sen, Chandan, Srinivas, Sangly
• Application Number:
  US11/610,465
• Publication Number:
  US 20070172392A1
• Time in Patent Office: Days
• US Class Current: 422/82.80
• CPC Class Codes: A61B 5/14556 by fluorescence A61B5/14555 takes precedence

Abstract

An apparatus, system and method for measuring oxygen concentration for exciting and detecting oxygen-sensitive fluorescence in biological tissues to detect oxygen levels (e.g., the partial pressure of oxygen).

Claims

1. An apparatus for measuring an oxygen level, the apparatus comprising:

a plurality of optical fibers;

an enclosure surrounding the optical fibers to form a fiber optic bundle; and

an oxygen-sensitive dye disposed at a first end of the fiber optic bundle,

wherein at least one of the optical fibers is an excitation fiber for transmitting an intensity modulated light forming a sine wave to the dye,

wherein at least one of the optical fibers is an emission fiber for transmitting an emission from the dye, and

wherein the emission results from the intensity modulated light contacting the dye.

2. The apparatus of claim 1, wherein the oxygen level is a partial pressure of oxygen.

3. The apparatus of claim 1, wherein the oxygen-sensitive dye is one of Tris(1, 10 phenatroline) ruthenium (II) and Pd-meso-tetra (4-carboxyphenyl) porphyrin.

4. The apparatus of claim 1, wherein the dye is bound to silica microparticles in silicone rubber.

5. The apparatus of claim 1, wherein the first end of the fiber optic bundle is inserted into a wound prior to the intensity modulated light being transmitted through the excitation fiber.

6. The apparatus of claim 1, wherein the oxygen level measured by the apparatus is used to control a dosage of oxygen administered during oxygen therapy.

7. The apparatus of claim 1, wherein a second end of the fiber optic bundle is bifurcated into a first arm and a second arm,

wherein the first arm includes all excitation fibers, and

wherein the second arm includes all emission fibers.

8. The apparatus of claim 7, wherein the first arm is connected to an excitation module for generating the intensity modulated light,

wherein the second arm is connected to an emission module for detecting the emission, and

wherein the emission module determines a phase delay between the intensity modulated light and the emission.

9. The apparatus of claim 8, wherein at least one of the excitation module and the emission module comprises a radio receiver and transmitter.

10. An apparatus for measuring an oxygen level, the apparatus comprising:

a heating element for raising the temperature of skin at a site to be measured;

a sensor unit including an oxygen-sensitive dye;

an excitation source for generating excitation light in the form of an intensity modulated sine wave;

a detector for detecting an emission from the dye in response to the excitation light contacting the dye; and

a phase detector for detecting a phase delay between the excitation light and the emission.

11. The apparatus of claim 10, wherein the excitation source comprises at least one light emitting diode.

12. The apparatus of claim 10, wherein the detector comprises an avalanche photodiode.

13. The apparatus of claim 10, wherein the detector comprises a photomultiplier.

14. The apparatus of claim 10, wherein the phase detector comprises a dual phase lock-in amplifier.

15. The apparatus of claim 10, wherein the phase delay is transmitted to a computer for processing, and

wherein the processing includes determining the oxygen level from the phase delay.

16. The apparatus of claim 15, wherein the oxygen level is displayed by the computer.

17. A method of measuring an oxygen level, the method comprising:

generating an excitation wave as an intensity modulated light forming a sine wave;

focusing the excitation wave on an oxygen-sensitive dye;

detecting an emission wave emitted in response to the excitation wave contacting the dye;

determining a phase delay between the excitation wave and the emission wave.

18. The method of claim 17, further comprising locating the dye inside a wound prior to focusing the excitation wave on the dye.