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Synthetic chemokine receptor ligands and methods of use thereof

  • US 20070172446A1
  • Filed: 05/13/2004
  • Published: 07/26/2007
  • Est. Priority Date: 05/16/2003
  • Status: Abandoned Application
First Claim
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1. A synthetic CXCR3 polypeptide ligand comprising a polypeptide of from about 70 to about 125 amino acids in length, optionally further including an additional methionine attached to the ordinarily first amino acid at the N-terminus, the amino acid sequence of the polypeptide comprising, in sequence, discrete sub-sequences corresponding in amino acid identity and number to sub-sequences of different, naturally occurring CXCR3 ligands selected from IP-10, I-TAC, and Mig, where the amino acid sequence of the synthetic CXCR3 polypeptide differs from the amino acid sequence of naturally occurring CXCR3 ligands IP-10, I-TAC, and Mig.

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