Method and apparatus for isolating the vascular component in digital temerature monitoring

• US 20070173727A1
• Filed: 08/14/2006
• Published: 07/26/2007
• Est. Priority Date: 07/06/2004
• Status: Abandoned Application

• Current Assignee: Endothelix, Inc.
• Original Assignee: Endothelix, Inc.
• Inventors: O'Brien, Timothy, Johnson, Mark, Jamieson, Craig, Naghavi, Morteza
• Application Number:
  US11/504,225
• Publication Number:
  US 20070173727A1
• Time in Patent Office: Days
• US Class Current: 600/483
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61B 5/6806 Gloves
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips

Abstract

Methods and apparatus are provided for identifying and minimizing neurovascular contributions to determinations of endothelial function, including by digital temperature monitoring such that an accurate status of vascular reactivity can be obtained. Methods are also provided for identifying individuals having increased sympathetic nervous system activity impacting peripheral vascular function as well as for determining a status of diabetic foot.

Claims

1. A method for identifying and controlling neurovascular influence in endothelial function measurement in a patient, comprising:

measuring skin temperatures on a test body part and a contralateral control body part simultaneously;

determining if the skin temperatures are above a set minimum temperature;

if the set minimum temperature is attained, automatically providing a vasostimulant to the subject to substantially cease blood flow to the test body part;

continuously monitoring the skin temperature changes of the test and control body parts during provision of the vasostimulant;

automatically removing the vasostimulant to allow blood flow to the body part;

comparing the skin temperatures to both the test and control body parts before, during and after removal of the vasostimulant; and

determining whether the measured temperature over time of the control body part is substantially stable.

2. The method of claim 1, wherein the patient is stabilized for a period of between 5 and 30 minutes prior to beginning measurement of skin temperatures.

3. The method of claim 1, wherein the set minimum temperature is about 28°

C.

4. The method of claim 1, wherein the contralateral body part comprises a plurality of contralateral body parts.

5. The method of claim 1, wherein the body part is a first hand on the subject, and the contralateral body part is a second hand on the subject.

6. The method of claim 1, wherein the body part is a first foot on the subject, and the contralateral body part is a second foot on the subject.

7. The method of claim 1, wherein the body part is a finger on the subject, and the contralateral body part is a corresponding finger on the subject.

8. The method of claim 1, further comprising determining a Doppler flow in the test and/or control body parts.

9. The method of claim 1, further comprising determining a blood flow rate by near infrared spectroscopy.

10. The method of claim 1, wherein the temperature response to the vasostimulant is analyzed to screen the patient for white coat hypertension.

11. The method of claim 1, wherein the temperature response to the vasostimulant is analyzed to monitor the patient'"'"'s response to mental stress.

12. The method of claim 1, further comprising changing the skin temperature of the body part by heating and/or cooling the body part with a thermal device.

13. The method of claim 1, wherein the temperature response to the vasostimulant is analyzed to determining whether the patient has diabetic foot.

14. The method of claim 1, wherein the temperature response to the vasostimulant is analyzed to determining a status and progression of diabetic foot in the patient.

15. The method of claim 1, wherein the temperature response to the vasostimulant is analyzed to determining a response of the patient to diabetic therapies.

16. The method of claim 1, wherein the steps are implemented by a computer program controlling a thermal energy senor engine, a vasostimulant engine, and a plotting engine.

17. The method of claim 1, wherein the temperature is monitored body parts having a reduced neurovascular component selected from a finger webbing, a palm and a forearm.

18. A method for identifying a status of diabetic foot in a patient, comprising:

determining a measure of perfusion on both feet of a diabetic patient before during and after providing a vasostimulant to the patient;

comparing the measures of perfusion between the feet.

19. The method of claim 18, wherein a baseline measure of perfusion of both feet of the patient is performed and a further measure of perfusion is performed after administration of nitrite/nitrate compound.

20. The method of claim 18, wherein the measure of perfusion is selected from the group consisting of:

digital temperature monitoring, Doppler ultrasonography, infrared thermography, and combinations thereof.