Apparatus and method for controlling insulin infusion with state variable feedback
First Claim
1. A method of infusing a fluid into a body of a user, the method comprising:
- delivering a basal amount of fluid to a body of a user at a predetermined basal rate;
determining a bolus amount of fluid to be delivered to the body of the user, determining at least one state variable;
determining, based on the at least one state variable, an additional amount of fluid to be delivered to the body of the user with the bolus amount of fluid;
infusing the determined bolus amount of fluid and the determined additional amount of fluid to the user; and
reducing the basal rate by the additional amount of fluid delivered with the bolus amount of fluid.
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Accused Products
Abstract
An infusion system, which may be a closed loop infusion system or “semi-closed-loop” system, uses state variable feedback to controls the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that are displayed or sounded or otherwise provide indications to the user prior to insulin delivery. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The delivery system infuses a liquid into the user at a rate dictated by the commands from the controller. The system may use three state variables, subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an addition amount of liquid to be infused as a bolus and to be removed from the basal delivery of the liquid.
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Citations
22 Claims
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1. A method of infusing a fluid into a body of a user, the method comprising:
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delivering a basal amount of fluid to a body of a user at a predetermined basal rate;
determining a bolus amount of fluid to be delivered to the body of the user, determining at least one state variable;
determining, based on the at least one state variable, an additional amount of fluid to be delivered to the body of the user with the bolus amount of fluid;
infusing the determined bolus amount of fluid and the determined additional amount of fluid to the user; and
reducing the basal rate by the additional amount of fluid delivered with the bolus amount of fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of infusing insulin into a body of a user, the method comprising:
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delivering a basal amount of insulin at a predetermined basal rate;
obtaining a blood glucose concentration of a user;
generating a controller input based on the blood glucose concentration;
generating commands by a proportional plus, integral plus, derivative (PID) controller from the controller input;
determining, based on the commands from the PID controller, a bolus amount of insulin to be delivered to the body of the user, determining at least one state variable selected from the group consisting of subcutaneous insulin concentration, plasma insulin concentration, and insulin effect;
determining, based on the at least one state variable and at least one corresponding gain, an additional amount of insulin to be delivered to the body of the user with the bolus amount of insulin;
infusing the determined bolus amount of insulin and the determined additional amount of insulin to the user; and
reducing the basal rate by the additional amount of insulin delivered with the bolus amount of insulin.
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14. An apparatus for infusing a fluid into a body of a user, the apparatus comprising:
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a housing;
a pump inside the housing for delivering a fluid into a body of a user; and
at least one controller to control delivery of the fluid from the housing by the pump, wherein the at least one controller;
controls delivery of a basal amount of fluid to a body of a user at a predetermined basal rate, determines a bolus amount of fluid to be delivered to the body of the user, determines at least one state variable, determines, based on the at least one state variable, an additional amount of fluid to be delivered to the body of the user with the bolus amount of fluid, controls delivery of the determined bolus amount of fluid and the determined additional amount of fluid to the user, and reduces the basal rate by the additional amount of fluid delivered with the bolus amount of fluid. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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Specification