Analysis element for use in method of testing specimen

• US 20070178009A1
• Filed: 03/15/2005
• Published: 08/02/2007
• Est. Priority Date: 03/18/2004
• Status: Abandoned Application

• Current Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Original Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Inventors: Sudo, Yukio, Abe, Yoshihiko, Sakaino, Yoshiki
• Application Number:
  US10/592,230
• Publication Number:
  US 20070178009A1
• Time in Patent Office: Days
• US Class Current: 422/56
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2562/0295 Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150099 by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150274 Manufacture or production processes or steps for blood sampling devices
• CPC Class Codes: A61B 5/150343 Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes sampling from within body cavities A61B5/150015, A61B5/150045
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence
• CPC Class Codes: G01N 21/4738 Diffuse reflection precedence is given to G01N21/55 - G01N21/57 if specular component is taken into consideration, e.g. also for testing fluids, fibrous materials
• CPC Class Codes: G01N 21/75 Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated systems in which material is burnt in a flame or plasma G01N21/72, G01N21/73
• CPC Class Codes: G01N 31/22 using chemical indicators G01N31/02 takes precedence

Abstract

An analysis element for use in a blood test method enabling easy and simple operations that are performed quickly up to measurement, an analysis element for use in a blood test method that operations up to the measurement for many components can be quickly performed, and that is safe and has a sufficient measurement accuracy thereof, and an analysis element for use in a test method using body fluids and urines of humans and animals, plain water, seawater, soil extract, agricultural products, marine products, processed-food extracts, and liquid for use in scientific research as specimens, are provided, the present invention relates to a multi-component measurement dry analysis element for use in a method for testing a specimen, the method using an area sensor as a detector to obtain a result of measurement according to information represented by 1000 pixels or more per one component, and to perform simultaneous measurements of plural components.

Claims

1. A multi-component measurement dry analysis element for use in a method for testing a specimen, the method using an area sensor as a detector to obtain a result of measurement according to information of 1000 pixels or more per one component and to perform simultaneous measurements of plural components.

2. The multi-component measurement dry analysis element according to claim 1, which comprises a flow channel, a color-developing reactive reagent and a portion supporting said color-developing reactive reagent,

wherein at least one of a width, a depth, and a length of the flow channel is not less than 1 mm, and

wherein a width of the portion supporting the color-developing reactive reagent is not less than twice the width of the flow channel, and/or, a length of the portion supporting the color-developing reactive reagent is not less than 0.4 times the length of the flow channel.

3. The multi-component measurement dry analysis element according to claim 2, which comprises a filtering portion containing a water-insoluble substance that has an equivalent circle diameter of not more than 5, μ

m and a length equal to or longer than an equivalent circle radius.

4. The multi-component measurement dry analysis element according to claim 2, which comprises a filtering portion containing fibers having an equivalent circle diameter of not more than 5 μ

m.

5. The multi-component measurement dry analysis element according to claim 2, which comprises a filtering portion containing:

fibers having an equivalent circle diameters of not more than 5 μ

m; and

a porous membrane.

6. The multi-component measurement dry analysis element according to claim 2, which comprises a filtering portion containing:

glass fibers having an equivalent circle diameters of not more than 5 μ

m; and

a porous membrane.

7. The multi-component measurement dry analysis element according to claim 2, which comprises a dry multilayer film as a reagent layer in the portion supporting the color-developing reactive reagent.

8. The multi-component measurement dry analysis element according to claim 2, which comprises a dry multilayer film, to which a porous membrane is adhered, as a reagent layer in the portion supporting the color-developing reactive reagent.

9. The multi-component measurement dry analysis element according to claim 2, which comprise a dry multilayer film, to which fine particles having a diameter of not more than 100 μ

m, are adhered, as a reagent layer in the portion supporting the color-developing reactive reagent.

10. The multi-component measurement dry analysis element according to claim 2, wherein the portion supporting the color-developing reactive reagent is a cell connected to the flow channel.

11. The multi-component measurement dry analysis element according to claim 2, which comprises a dry multilayer film as a reagent layer of the portion supporting the color-developing reactive reagent, wherein a specimen is supplied to a reagent through a polymer porous element.

12. The multi-component measurement dry analysis element according to claim 2, which comprises a dry multilayer film as a reagent layer of the portion supporting the color-developing reactive reagent, wherein a specimen is supplied to a reagent through a space formed by engraving the flow channel itself.

15. A blood collection unit comprising:

the multi-component measurement dry analysis element according to claim 2;

and

a blood collecting instrument containing at least two portions capable of sliding from each other while maintaining substantially airtight state,

wherein the blood collecting instrument houses the multi-component measurement dry analysis element, and the at least two portions are slidably combined to form an enclosed space therein capable of being depressurized.

16. The blood collection unit according to claim 15, wherein the blood collecting instrument has a puncture needle having a diameter of not more than 100 μ

m and having a needle tip angle of not more than 20°

.

19. The multi-component measurement dry analysis element according to claim 2, wherein the specimen is a liquid for use in tests of environment-related materials.

20. The multi-component measurement dry analysis element according to claim 2, wherein the specimen is a liquid for use in tests of agricultural products, marine products, or foods.

21. The multi-component measurement dry analysis element according to claim 2, wherein the specimen is a liquid for use in scientific research.

13. A multi-component measurement dry analysis element for use in a method for testing a specimen, the method using a line sensor as a detector to perform simultaneous measurements of plural components, wherein the multi-component measurement dry analysis element comprises:

a flow channel;

a color-developing reactive reagent;

a portion supporting the color-developing reactive reagent; and

a filtering portion containing a water-insoluble substance that has an equivalent circle diameter of not more than 5 μ

m and a length equal to or longer than an equivalent circle radius,

wherein at least one of a width, a depth and a length of the flow channel is not less than 1 mm, and

wherein a width of the portion supporting the color-developing reactive reagent is not less than twice the width of said flow channel, and/or, a length of the portion supporting the color-developing reactive reagent is not less than 0.4 times the length of the flow channel.

17. A blood collection unit comprising:

the multi-component measurement dry analysis element according to claim 13;

and

a blood collecting instrument containing at least two portions capable of sliding from each other while maintaining substantially airtight state,

wherein the blood collecting instrument houses the multi-component measurement dry analysis element, and the at least two portions are slidably combined to form an enclosed space therein capable of being depressurized.

18. The blood collection unit according to claim 17, wherein the blood collecting instrument has a puncture needle having a diameter of not more than 100 μ

m and having a needle tip angle of not more than 20°

.

14. A multi-component measurement dry analysis element for use in a method for testing a specimen, the method using an electrochemical sensor as a detector to perform simultaneous measurements of plural components, wherein the multi-component measurement dry analysis element comprises:

a flow channel;

a reactive reagent;

a portion supporting the reactive reagent; and

a filtering portion containing a water-insoluble substance that has an equivalent circle diameter of not more than 5 μ

m and a length equal to or longer than an equivalent circle radius,

wherein at least one of a width, a depth and a length of the flow channel is not less than 1 mm.