System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
First Claim
1. A method for integrating genetic, phenotypic and medical data into a database according to a standardized ontology, the method consisting of:
- (i) defining and creating a standardized ontology that can accommodate all of the relevant pieces of data and data fields, (ii) generating an interface based on the standard ontology that allows an agent to describe the data fields of the input data appropriately, and then input the data, (iii) generating a cartridge that is capable of translating the data into a format that is compliant with the standardized ontology, and (iv) translating and loading the input data into the database.
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Accused Products
Abstract
The system described herein enables clinicians and researchers to use aggregated genetic and phenotypic data from clinical trials and medical records to make the safest, most effective treatment decisions for each patient. This involves (i) the creation of a standardized ontology for genetic, phenotypic, clinical, pharmacokinetic, pharmacodynamic and other data sets, (ii) the creation of a translation engine to integrate heterogeneous data sets into a database using the standardized ontology, and (iii) the development of statistical methods to perform data validation and outcome prediction with the integrated data. The system is designed to interface with patient electronic medical records (EMRs) in hospitals and laboratories to extract a particular patient'"'"'s relevant data. The system may also be used in the context of generating phenotypic predictions and enhanced medical laboratory reports for treating clinicians. The system may also be used in the context of leveraging the huge amount of data created in medical and pharmaceutical clinical trials. The ontology and validation rules are designed to be flexible so as to accommodate a disparate set of clients. The system is also designed to be flexible so that it can change to accommodate scientific progress and remain optimally configured.
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Citations
18 Claims
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1. A method for integrating genetic, phenotypic and medical data into a database according to a standardized ontology, the method consisting of:
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(i) defining and creating a standardized ontology that can accommodate all of the relevant pieces of data and data fields, (ii) generating an interface based on the standard ontology that allows an agent to describe the data fields of the input data appropriately, and then input the data, (iii) generating a cartridge that is capable of translating the data into a format that is compliant with the standardized ontology, and (iv) translating and loading the input data into the database. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification