Apparatus for evaluating a patient's hemodynamic status using heart-lung interaction

• US 20070179386A1
• Filed: 01/31/2007
• Published: 08/02/2007
• Est. Priority Date: 01/31/2006
• Status: Abandoned Application

• Current Assignee: Edwards Lifesciences AG (Edwards Lifesciences Corporation)
• Original Assignee: UP Management GmbH & Co Med-Systems KG.
• Inventors: Knoll, Reinhold, Pfeiffer, Ulrich, Michard, Frederic
• Application Number:
  US11/700,500
• Publication Number:
  US 20070179386A1
• Time in Patent Office: Days
• US Class Current: 600/485
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/0836 Measuring rate of CO2 production
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61M 16/0057 Pumps therefor

Abstract

Apparatus for evaluating a mechanically ventilated patient'"'"'s hemodynamic status, adapted to provide a respiratory variation diagram of a hemodynamic variable, and being capable of deriving the value of a hemodynamic parameter for each mechanical breath cycle as well as an assessment of its suitability for the hemodynamic analysis on basis of the respiratory variation diagram. A method is also provided.

Claims

1. An apparatus for evaluating a hemodynamic status of a mechanically ventilated patient, comprising:

a device adapted to analyze a respiratory variation of a hemodynamic variable, and being capable of deriving a value of a hemodynamic parameter for each mechanical breath cycle as well as an assessment of a suitability of the value of the hemodynamic parameter for a hemodynamic analysis on the basis of a respiratory variation diagram.

2. The apparatus according to claim 1, wherein the hemodynamic variable is an arterial pulse pressure (PP) and the hemodynamic parameter is an arterial pulse pressure variation (PPV).

3. The apparatus according to claim 2, further comprising an arterial catheter for measuring the arterial pulse pressure (PP).

4. The apparatus according to claim 2 wherein the apparatus is adapted to make use of the equation

$\mathrm{PPV}=2$

PP 



max - PP 



min PP 



max + PP 



min

wherein PPmax is a maximum arterial pulse pressure (PP) per mechanical breath cycle, and PPmin is a minimum arterial pulse pressure (PP) per mechanical breath cycle.

5. The apparatus according to claim 1, wherein the hemodynamic variable is the arterial systolic pressure and the hemodynamic parameter is the arterial systolic pressure variation.

6. The apparatus according to claim 5, further comprising an arterial catheter for measuring the arterial systolic pressure.

7. The apparatus according to claim 1 wherein the hemodynamic variable is the left ventricular stroke volume and the hemodynamic parameter is the left ventricular stroke volume variation.

8. The apparatus according to claim 7, further comprising a sensor allowing the beat by beat measurement of the left ventricular stroke volume.

9. The apparatus according to claim 1 wherein the hemodynamic variable is the pulse oximetry plethysmographic waveform and the hemodynamic parameter is the pulse oximetry plethysmographic waveform variation.

10. The apparatus according to claim 9, further comprising a pulse oximeter probe for measuring the pulse oximetry plethysmographic waveform.

11. The apparatus according to claim 1 wherein the hemodynamic variable is the pre-ejection period and the hemodynamic parameter is the pre-ejection period variation.

12. The apparatus according to claim 11, further comprising a recorder for simultaneously recording the ECG and either a pulse oximeter plethysmographic signal or an arterial pressure signal for determining the pre-ejection period.

13. The apparatus according to claim 1 wherein the apparatus is adapted to perform for each value of the hemodynamic parameter the assessment of the suitability thereof on basis of the detection of arrhythmia of the patient.

14. The apparatus according to claim 13 wherein the apparatus is adapted to detect arrhythmia of the patient by registering time intervals between beat-to-beat peaks of the hemodynamic variable, determining a mean time interval value on basis of the respiratory variation diagram, and detecting a mechanical breath cycle comprising at least one time interval exceeding a predetermined deviation from the mean time interval value in order to exclude the value of the hemodynamic parameter assigned to said mechanical breath cycle from the hemodynamic analysis.

15. The apparatus according to claim 14 wherein the predetermined deviation is 15% of the mean time interval value.

16. The apparatus according to claim 13 wherein the apparatus is adapted to detect arrhythmia of the patient by making use of an ECG.

17. The apparatus according to claim 1 wherein the apparatus is adapted to register time intervals (t) between the beat-to-beat peaks of an arterial pulse pressure (PP), determine a mean time interval value ( t) on the basis of the respiratory variation diagram, and wherein the hemodynamic variable is the normalized pulse pressure (PPn) defined as

$\mathrm{PPn}=\mathrm{PP}$



t t _ ,

and the hemodynamic parameter is the arterial pulse pressure variation (PPV).

18. The apparatus according to claim 17, further comprising an arterial catheter for measuring the arterial pulse pressure (PP).

19. The apparatus according to claim 17 wherein the apparatus is adapted to make use of the equation

$\mathrm{PPV}=2$

PPn 



max - PPn 



min PPn 



max + PPn 



min ,

wherein PPnmax is the maximum normalized arterial pulse pressure (PPn) per mechanical breath cycle, and PPnmin is the minimum normalized arterial pulse pressure (PPn) per mechanical breath cycle (30).

20. The apparatus according to claim 1 wherein the apparatus is adapted to perform for each value of the hemodynamic parameter the assessment of the suitability thereof on the basis of the detection of irregular breathing patterns of the patient.

21. The apparatus according to claim 20 wherein the apparatus is adapted to detect irregular breathing patterns of the patient by registering the values of the hemodynamic parameter, and detecting at least one mechanical breath cycle pattern comprised of at least three consecutive mechanical breath cycles comprising the values of the hemodynamic parameter exceeding a predetermined deviation from each other in order to exclude the values of the hemodynamic parameter assigned to said mechanical breath cycle pattern from the hemodynamic analysis.

22. The apparatus according to claim 21 wherein the predetermined deviation is 15% of the mean value of the values of the hemodynamic parameter assigned to said mechanical breath cycle pattern.

23. The apparatus according to claim 20 wherein the apparatus is adapted to detect irregular breathing patterns of the patient by making use of an airway pressure curve or a central venous pressure curve or a thoracic bioimpedance signal or an airway flow curve, or a capnographic curve, or a respiratory inductive plethysmographic signal or a magnetometer signal or a tidal volume measurement.

24. The apparatus according to claim 1 wherein the apparatus is adapted to display the respiratory variation diagram of the hemodynamic variable in such manner that the respiratory variation diagram is shown as vertical bar graph, wherein for each beat-to-beat curve section of the hemodynamic variable an individual bar is plotted, which is defined between the maximum value and the minimum value of beat-to-beat curve section of the hemodynamic variable.

25. A method for evaluating a hemodynamic status of a mechanically ventilated patient, comprising:

analyzing a respiratory variation of a hemodynamic variable;

deriving the value of a hemodynamic parameter for each mechanical breath cycle; and

assessing of a suitability of the value of the hemodynamic parameter for a hemodynamic analysis on the basis of a respiratory variation diagram.