THERAPEUTIC AGENT ELUDING IMPLANT WITH PERCUTANEOUS SUPPLY

• US 20070179609A1
• Filed: 01/26/2007
• Published: 08/02/2007
• Est. Priority Date: 01/27/2006
• Status: Abandoned Application

• Current Assignee: Medicinelodge, Inc (Nelso Antolotti)
• Original Assignee: Medicinelodge, Inc (Nelso Antolotti)
• Inventors: Justin, Daniel F., Sinnott, M. Mary, Fallin, T. Wade, Goble, E. Marlowe, Lewis, Chad W., Gerbec, Daniel E., Mohr, Karen
• Application Number:
  US11/627,709
• Publication Number:
  US 20070179609A1
• Time in Patent Office: Days
• US Class Current: 623/16.110
• CPC Class Codes: A61B 17/60 for external osteosynthesis, e.g. distractors, contractors
• CPC Class Codes: A61B 17/7001 Screws or hooks combined with longitudinal elements which do not contact vertebrae A61B17/7058 takes precedence
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/86 Pins or screws or threaded wires; nuts therefor A61B17/72 take precedence
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61F 2/0059 Cosmetic or alloplastic implants A61F2/10 - A61F2/16, A61F2/28 take precedence
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61F 2/2803 for mandibular reconstruction temporo-mandibular joints A61F2/3099; bone plates for the jaw A61B17/8071
• CPC Class Codes: A61F 2/30721 Accessories
• CPC Class Codes: A61F 2/3099 for temporo-mandibular [TM, TMJ] joints endoprostheses for mandibular reconstruction A61F2/2803
• CPC Class Codes: A61F 2/32 for the hip
• CPC Class Codes: A61F 2/34 Acetabular cups
• CPC Class Codes: A61F 2/36 Femoral heads ; Femoral endoprostheses
• CPC Class Codes: A61F 2/3662 Femoral shafts
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/3804 for elbows
• CPC Class Codes: A61F 2/3859 Femoral components
• CPC Class Codes: A61F 2/3877 Patellae or trochleae
• CPC Class Codes: A61F 2/389 Tibial components A61F2/3868 takes precedence
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2/4081 : Glenoid components, e.g. cups
• CPC Class Codes: A61F 2/4202 : for ankles
• CPC Class Codes: A61F 2/4261 : for wrists
• CPC Class Codes: A61F 2/4425 : made of articulated components
• CPC Class Codes: A61F 2/447 : substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
• CPC Class Codes: A61F 2002/2807 : Chin implants
• CPC Class Codes: A61F 2002/30125 : elliptical or oval
• CPC Class Codes: A61F 2002/30131 : horseshoe- or crescent- or C-shaped or U-shaped
• CPC Class Codes: A61F 2002/30429 : made by inserting a hook into a cooperating slot
• CPC Class Codes: A61F 2002/30449 : the adhesive being cement
• CPC Class Codes: A61F 2002/30487 : Circumferential cooperating grooves and beads on cooperating lateral surfaces of a mainly longitudinal connection
• CPC Class Codes: A61F 2002/305 : Snap connection
• CPC Class Codes: A61F 2002/30593 : hollow
• CPC Class Codes: A61F 2002/30624 : Hinged joint, e.g. with transverse axle restricting the movement
• CPC Class Codes: A61F 2002/30677 : Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/3068 : the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2002/30785 : parallel
• CPC Class Codes: A61F 2002/30787 : inclined obliquely with respect to each other
• CPC Class Codes: A61F 2002/30822 : Circumferential grooves
• CPC Class Codes: A61F 2002/30878 : with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
• CPC Class Codes: A61F 2002/30884 : Fins or wings, e.g. longitudinal wings for preventing rotation within the bone cavity
• CPC Class Codes: A61F 2002/30904 : serrated profile, i.e. saw-toothed
• CPC Class Codes: A61F 2002/30991 : Mandibular components
• CPC Class Codes: A61F 2002/30993 : Temporal components
• CPC Class Codes: A61F 2002/3401 : with radial apertures, e.g. radial bores for receiving fixation screws
• CPC Class Codes: A61F 2002/3611 : Heads or epiphyseal parts of femur
• CPC Class Codes: A61F 2002/3625 : Necks
• CPC Class Codes: A61F 2002/3631 : with an integral complete or partial peripheral collar or bearing shoulder at its base
• CPC Class Codes: A61F 2002/3813 : for ulno-humeral joints
• CPC Class Codes: A61F 2002/3822 : Humeral components
• CPC Class Codes: A61F 2002/3831 : Ulnar components
• CPC Class Codes: A61F 2002/4018 : Heads or epiphyseal parts of humerus
• CPC Class Codes: A61F 2002/4029 : Necks
• CPC Class Codes: A61F 2002/4205 : Tibial components
• CPC Class Codes: A61F 2002/4207 : Talar components
• CPC Class Codes: A61F 2002/4264 : for radio-carpal joints
• CPC Class Codes: A61F 2002/443 : having two transversal endplates and at least one intermediate component
• CPC Class Codes: A61F 2220/0025 : Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2220/005 : using adhesives
• CPC Class Codes: A61F 2230/0008 : elliptical or oval
• CPC Class Codes: A61F 2230/0013 : Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2250/0068 : the pharmaceutical product being in a reservoir
• CPC Class Codes: A61M 2210/02 : Bones
• CPC Class Codes: A61M 5/14244 : adapted to be carried by the patient, e.g. portable on the body

Abstract

The present invention provides integration between an implant system and therapeutic agent delivery system. The implant may include a prosthesis that restores biomechanical function while decreasing long-term disability and pain by replacing damaged or degenerate tissues, or a reconstructive implant such as a bone plate. The therapeutic agent delivery system may include one or more channels either permanently or reversibly attached to the implant. The channels may receive medication from an external pump via a percutaneous catheter. The channels deliver the medication to one or more medicating surfaces of the implant to treating proximate tissues.

Claims

1. A system comprising:

a prosthesis comprising;

a channel shaped to convey a therapeutic agent; and

a medicating surface adjacent to an intra-articular space, the medicating surface having a first opening in communication with the channel to release the therapeutic agent into the intra-articular space.

2. A system as recited in claim 1, further comprising a conduit permanently attached to the prosthesis to percutaneously deliver the therapeutic agent to the channel.

3. A system as recited in claim 2, further comprising a coupling configured to provide a permanent link between the conduit and the channel.

4. A system as recited in claim 1, further comprising a conduit reversibly attached to the prosthesis to percutaneously deliver the therapeutic agent to the channel.

5. A system as recited in claim 4, further comprising a coupling configured to provide a removable link between the conduit and the channel.

6. A system as recited in claim 4, further comprising a coupling configured to provide a biodegradable link between the conduit and the channel.

7. A system as recited in claim 1, wherein the channel comprises a centroid positioned substantially collinear with an exterior surface of the prosthesis.

8. A system as recited in claim 1, wherein the channel comprises a centroid positioned outside an exterior surface of the prosthesis.

9. A system as recited in claim 1, wherein the medicating surface further comprises a second opening having a size different from a size of the first opening.

10. A system as recited in claim 1, further comprising a conduit configured to be captured by the channel to percutaneously deliver the therapeutic agent to the first opening.

11. A system as recited in claim 1, wherein the prosthesis is selected from the group consisting of a knee prosthesis, a hip prosthesis, an ankle prosthesis, a shoulder prosthesis, an artificial spinal disc, an intervertebral fusion prosthesis, a facet prosthesis, an elbow prosthesis, and a temporomandibular joint prosthesis.

12. A system as recited in claim 11, wherein the prosthesis comprises a knee prosthesis configured to replace at least one articular surface of a knee.

13. A method for treating a joint, the method comprising:

preparing a surface of a bone of the joint;

attaching a prosthesis to the prepared bone surface, the prosthesis comprising a channel shaped to convey a therapeutic agent, and a medicating surface having a first opening in communication with the channel;

wherein attaching the prosthesis to the prepared bone surface comprises positioning the first opening to release a therapeutic agent into the intra-articular space of the joint.

14. The method of claim 13, further comprising urging the therapeutic agent to flow percutaneously through a conduit permanently attached to the prosthesis, into the channel from the conduit, and into the intra-articular space via the first opening.

15. The method of claim 13, further comprising:

reversibly attaching a conduit to the prosthesis; and

urging the therapeutic agent to flow percutaneously through the conduit, into the channel from the conduit, and into the intra-articular space via the first opening.

16. The method of claim 13, further comprising urging the therapeutic agent to flow percutaneously through a conduit captured by the channel, into the channel, and into the intra-articular space via the first opening.

17. The method of claim 13, wherein the joint comprises a knee, wherein attaching the prosthesis to the prepared bone surface comprises replacing at least one articular surface of the knee.

18. A system comprising:

a prosthesis configured to articulate with an adjacent bone or implant, the prosthesis comprising;

a channel shaped to convey a therapeutic agent; and

a medicating surface in contact with soft tissue, the medicating surface having a first opening in communication with the channel to release the therapeutic agent to the soft tissue.

19. A system as recited in claim 18, further comprising a conduit permanently attached to the prosthesis to percutaneously deliver the therapeutic agent to the channel.

20. A system as recited in claim 19, further comprising a coupling configured to provide a permanent link between the conduit and the channel.

21. A system as recited in claim 18, further comprising a conduit reversibly attached to the prosthesis to percutaneously deliver the therapeutic agent to the channel.

22. A system as recited in claim 21, further comprising a coupling configured to provide a removable link between the conduit and the channel.

23. A system as recited in claim 21, further comprising a coupling configured to provide a biodegradable link between the conduit and the channel.

24. A system as recited in claim 18, wherein the channel comprises a centroid positioned substantially collinear with an exterior surface of the prosthesis.

25. A system as recited in claim 18, wherein the channel comprises a centroid positioned outside an exterior surface of the prosthesis.

26. A system as recited in claim 18, wherein the medicating surface further comprises a second opening having a size different from a size of the first opening.

27. A system as recited in claim 18, further comprising a conduit configured to be captured by the channel to percutaneously deliver the therapeutic agent to the first opening.

28. A system as recited in claim 18, wherein the prosthesis is selected from the group consisting of a knee prosthesis, a hip prosthesis, an ankle prosthesis, a shoulder prosthesis, an artificial spinal disc, an intervertebral fusion prosthesis, a facet prosthesis, an elbow prosthesis, and a temporomandibular joint prosthesis.

29. A system as recited in claim 28, wherein the prosthesis comprises a knee prosthesis configured to replace at least one articular surface of a knee.

30. A method for treating a joint, the method comprising:

preparing a surface of a bone of the joint;

attaching a prosthesis to the prepared bone surface, the prosthesis comprising a channel shaped to convey a therapeutic agent, and a medicating surface having a first opening in communication with the channel;

wherein the prosthesis is configured to replace at least one articular surface of the joint;

wherein attaching the prosthesis to the prepared bone surface comprises positioning the first opening to release a therapeutic agent to the soft tissue.

31. The method of claim 30, further comprising urging the therapeutic agent to flow percutaneously through a conduit permanently attached to the prosthesis, into the channel from the conduit, and into the intra-articular space via the first opening.

32. The method of claim 30, further comprising:

reversibly attaching a conduit to the prosthesis; and

urging the therapeutic agent to flow percutaneously through the conduit, into the channel from the conduit, and into the intra-articular space via the first opening.

33. The method of claim 30, further comprising urging the therapeutic agent to flow percutaneously through a conduit captured by the channel, into the channel, and into the intra-articular space via the first opening.

34. The method of claim 30, wherein the joint comprises a knee, wherein attaching the prosthesis to the prepared bone surface comprises replacing at least one articular surface of the knee.

35. A system comprising:

an implant configured to attach to an outer surface of a bone to span a fracture of the bone to facilitate healing of the fracture, the implant comprising;

a channel shaped to convey a therapeutic agent; and

a medicating surface having an opening in communication with the channel to release the therapeutic agent.

36. A system as recited in claim 35, further comprising a conduit permanently attached to the implant to percutaneously deliver the therapeutic agent to the channel.

37. A system as recited in claim 35, further comprising a conduit reversibly attached to the implant to percutaneously deliver the therapeutic agent to the channel.

38. A system as recited in claim 35, wherein the channel comprises a centroid positioned substantially collinear with an exterior surface of the implant.

39. A system as recited in claim 35, wherein the channel comprises a centroid positioned outside an exterior surface of the implant.

40. A system as recited in claim 35, wherein the medicating surface further comprises a second opening having a size different from a size of the first opening.

41. A system as recited in claim 35, further comprising a conduit configured to be captured by the channel to percutaneously deliver the therapeutic agent to the first opening.

42. A method for treating a bone fracture, the method comprising:

positioning an implant on a surface of the bone such that the implant spans the fracture, the implant comprising a channel shaped to convey a therapeutic agent, and a medicating surface having a first opening in communication with the channel; and

attaching the implant to the prepared bone surface.

43. The method of claim 42, further comprising urging the therapeutic agent to flow percutaneously through a conduit permanently attached to the implant, into the channel from the conduit, and to proximate tissue via the first opening.

44. The method of claim 42, further comprising:

reversibly attaching a conduit to the implant; and

urging the therapeutic agent to flow percutaneously though the conduit, into the channel from the conduit, and to proximate tissue via the first opening.

45. The method of claim 42, further comprising urging the therapeutic agent to flow percutaneously through a conduit captured by the channel, into the channel, and to proximate tissue via the first opening.