METALLIC COMPOSITE COATINGS FOR DELIVERY OF THERAPEUTIC AGENTS FROM THE SURFACE OF IMPLANTABLE DEVICES
First Claim
Patent Images
1. A method of forming a bioactive composite coating on a device comprising the steps of:
- providing an electrolytic solution comprising metal ions;
contacting the device with the electrolytic solution;
applying an electric charge across the device to form a first layer on the device;
providing an electrochemical solution comprising metal ions and a biologically active agent; and
contacting the device having said first layer with the electrochemical solution to form a second bioactive metal composite layer on the device.
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Abstract
A metallic composite coating, and methods for forming same, for an implantable medical device is disclosed. The composite coating comprises at least one metal or metallic tie layer formed on the surface of the device, followed by an electroless electrochemical cladding of one or more additional layers over the tie layer. One or more therapeutic or biologically active agents are co-deposited with at least one of the electroless electrochemical claddings.
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Citations
42 Claims
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1. A method of forming a bioactive composite coating on a device comprising the steps of:
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providing an electrolytic solution comprising metal ions;
contacting the device with the electrolytic solution;
applying an electric charge across the device to form a first layer on the device;
providing an electrochemical solution comprising metal ions and a biologically active agent; and
contacting the device having said first layer with the electrochemical solution to form a second bioactive metal composite layer on the device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of forming a composite coating, having one or more therapeutic agents, on an implantable structure comprising the steps of:
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providing a first electrochemical solution containing metal ions and a reducing agent;
contacting the implantable structure with said first electrochemical solution to form a first metallic matrix layer on the implantable structure;
providing a second electrochemical solution containing metal ions, a reducing agent and one or more therapeutic agents; and
contacting the implantable structure, having said first metallic matrix layer, with the second electrochemical solution to form a second metallic matrix layer containing said one or more therapeutic agents on the implantable structure. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method of forming a bioactive composite coating on a device comprising the steps of:
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providing an electrolytic solution containing metal ions;
contacting the device with the electrolytic solution;
applying an electric charge across the device to form a first layer on the device;
providing a first electrochemical solution containing metal ions and a reducing agent;
contacting the device with said first electrochemical solution to form a second layer on the device;
providing a second electrochemical solution containing metal ions, a reducing agent and at least one biologically active agent; and
contacting the device, having said first layer and said second layer, with the second electrochemical solution to form a third bioactive metal composite layer on the device. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method of forming a composite coating, having one or more therapeutic agents, on an implantable structure having a surface, comprising the steps of:
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providing an electrochemical solution containing metal ions and one or more therapeutic agents;
contacting the implantable structure with said electrochemical solution to form a composite coating including a metallic matrix and said one or more therapeutic agents within said metallic matrix; and
wherein the surface of the implantable structure is not sensitized prior to contact with electrochemical solution. - View Dependent Claims (40)
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41. A method of forming a bioactive composite coating on a device having a surface, comprising the steps of:
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providing an electrochemical solution containing metal ions and at least one biologically active agent;
contacting the surface of the device with said electrochemical solution to form a bioactive composite coating including a metallic matrix and said at least one or biologically active agent within said metallic matrix; and
wherein the device does not have a catalyst deposited on the surface prior to contact with the electrochemical solution. - View Dependent Claims (42)
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Specification