Methods and systems for mixing a multi-part fluoride varnish composition

• US 20070183986A1
• Filed: 02/06/2006
• Published: 08/09/2007
• Est. Priority Date: 02/06/2006
• Status: Abandoned Application

• Current Assignee: Ultradent Products Incorporated
• Original Assignee: Ultradent Products Incorporated
• Inventors: Wagner, Jeff, Loveridge, Dan, Allred, Peter
• Application Number:
  US11/348,055
• Publication Number:
  US 20070183986A1
• Time in Patent Office: Days
• US Class Current: 424/52
• CPC Class Codes: A61K 8/044 Suspensions
• CPC Class Codes: A61K 8/21 Fluorides; Derivatives thereof
• CPC Class Codes: A61K 8/36 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/9767 Pinaceae [Pine family], e.g. pine or cedar
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/988 Honey; Royal jelly, Propolis
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Methods and related systems for mixing a multi-phase fluoride varnish composition preparatory to applying it to a person'"'"'s teeth. The method includes the steps of providing a multi-phase fluoride varnish composition including a liquid hydrophobic adhesive phase and a solid fluoride salt (e.g., sodium fluoride) phase that is substantially insoluble in the liquid adhesive phase, and applying turbulence to the multi-phase composition within a closed vessel in order to substantially suspend the solid fluoride salt phase within the liquid hydrophobic adhesive phase while preventing spillage of the composition.

Claims

1. A method for mixing a multi-phase fluoride varnish composition preparatory to applying it to a person'"'"'s teeth, comprising:

providing a multi-phase fluoride varnish composition comprising a liquid hydrophobic adhesive phase and a solid fluoride salt phase that is substantially insoluble in the liquid hydrophobic adhesive phase, the multi-phase fluoride varnish composition being contained within a closed vessel; and

applying turbulence to the multi-phase fluoride varnish composition within the closed vessel in order to substantially suspend the solid fluoride salt phase within the liquid hydrophobic adhesive phase while preventing spillage of the varnish composition.

2. A method as recited in claim 1, wherein the closed vessel comprises a hollow cylindrical container including an inner wall and a plug slidably disposed within the hollow cylindrical container, the plug forming a seal against the inner wall, and wherein the step of applying turbulence to the multi-phase fluoride varnish composition comprises cycling the composition in and out of the hollow cylindrical container with the plug.

3. A method as recited in claim 2, wherein the multi-phase fluoride varnish composition is cycled in and out between about 2 and about 15 times.

4. A method as recited in claim 2, wherein the multi-phase fluoride varnish composition is cycled in and out between about 3 and about 12 times.

5. A method as recited in claim 2, wherein the multi-phase fluoride varnish composition is cycled in and out between about 5 and about 10 times.

6. A method as recited in claim 2, wherein the hollow cylindrical container comprises a syringe barrel of a first syringe and the plug comprises a plunger of a first syringe, the plunger being slidably disposed within the syringe barrel such that the closed vessel comprises a first syringe.

7. A method as recited in claim 6, wherein the closed vessel further comprises a second syringe coupleable to the first syringe, the closed vessel comprising a syringe-to-syringe mixing apparatus when the first syringe is coupled to the second syringe, the step of applying turbulence comprising cycling the multi-phase fluoride varnish composition back and forth between the first syringe and the second syringe of the syringe-to-syringe mixing apparatus.

8. A method as recited in claim 6, wherein the closed vessel further comprises a flexible bladder coupleable to a distal end of the first syringe, the step of applying turbulence comprising cycling the multi-phase fluoride varnish composition back and forth between the first syringe and the flexible bladder in order to substantially suspend the solid fluoride salt phase within the liquid hydrophobic adhesive phase.

9. A method as recited in claim 6, wherein the closed vessel further comprises a spring loaded barrel coupleable to a distal end of the first syringe, the step of applying turbulence comprising cycling the multi-phase fluoride varnish composition back and forth between the syringe barrel and the spring loaded barrel in order to substantially suspend the solid fluoride salt phase within the liquid hydrophobic adhesive-phase.

10. A method as recited in claim 9, wherein the multi-phase fluoride varnish composition is cycled back and forth between the syringe and the spring loaded barrel by alternatingly pressing and releasing the plunger of the first syringe.

11. A method as recited in claim 1, further comprising applying the multi-phase fluoride varnish composition to a person'"'"'s teeth.

12. A method as recited in claim 11, wherein the multi-phase fluoride varnish composition provides a visual contrast against the surface of the person'"'"'s teeth so as to allow a dental practitioner to easily determine where the multi-phase fluoride varnish composition has been applied.

13. A method as recited in claim 11, wherein the multi-phase fluoride varnish composition remains adhered to the person'"'"'s teeth so as to provide fluoride treatment to the teeth for at least about 8 hours.

14. A method as recited in claim 11, wherein the multi-phase fluoride varnish composition remains adhered to the person'"'"'s teeth so as to provide fluoride treatment to the teeth for at least about one day.

15. A method as recited in claim 11, wherein the multi-phase fluoride varnish composition remains adhered to the person'"'"'s teeth so as to provide fluoride treatment to the teeth for at least about two days.

16. A method as recited in claim 1, wherein the multi-phase fluoride varnish composition has a viscosity of at least about 1000 centipoise.

17. A method as recited in claim 1, wherein the multi-phase fluoride varnish composition has a viscosity between about 1300 centipoise and about 3500 centipoise.

18. A method as recited in claim 1, wherein the multi-phase fluoride varnish composition has a viscosity between about 1700 centipoise and about 2800 centipoise.

19. A system for mixing a multi-phase fluoride varnish composition preparatory to applying it to a person'"'"'s teeth, comprising:

a closed vessel for holding a multi-phase fluoride varnish composition;

a quantity of a multi-phase fluoride varnish composition comprising a liquid hydrophobic adhesive phase and a solid fluoride salt phase that is insoluble in the liquid hydrophobic adhesive phase, the quantity of multi-phase fluoride varnish composition being contained within the closed vessel; and

means for providing turbulence to the multi-phase fluoride varnish composition within the closed vessel so as to substantially suspend the solid fluoride salt phase within the liquid hydrophobic adhesive phase while preventing spillage of the varnish composition.

20. A system as recited in claim 19, wherein the closed vessel comprises a hollow cylindrical container including an inner wall and the means for providing turbulence comprises a plug slidably disposed within the hollow cylindrical container, the plug forming a seal against the inner wall.

21. A system as recited in claim 20, wherein the hollow cylindrical container comprises a syringe barrel of a first syringe and the plug comprises a plunger of a first syringe, the plunger being slidably disposed within the syringe barrel such that the closed vessel comprises a first syringe.

22. A system as recited in claim 21, wherein the closed vessel further comprises a second syringe coupleable to the first syringe, the closed vessel comprising a syringe-to-syringe mixing apparatus when the first syringe is coupled to the second syringe.

23. A system as recited in claim 21, wherein the closed vessel further comprises a flexible bladder coupleable to a distal end of the first syringe.

24. A system as recited in claim 23, wherein the flexible bladder is sufficiently stiff so as to be biased to a deflated configuration.

25. A system as recited in claim 21, wherein the closed vessel further comprises a spring loaded barrel coupleable to a distal end of the first syringe.

26. A system as recited in claim 19, wherein the closed vessel contains a single use quantity of the multi-phase fluoride varnish composition such that the closed vessel may be discarded after a single use.

27. A system as recited in claim 19, wherein the liquid hydrophobic adhesive phase comprises at least one of shellac or colophonium.

28. A system as recited in claim 19, wherein the multi-phase fluoride varnish composition further comprises at least one thickener.

29. A system as recited in claim 28, wherein the thickener comprises fumed silica.

30. A system as recited in claim 19, wherein the multi-phase fluoride varnish composition further comprises at least one sweetener.

31. A system as recited in claim 19, wherein the multi-phase fluoride varnish composition further comprises at least one flavorant.

32. A system as recited in claim 19, wherein the solid fluoride salt phase comprises sodium fluoride.

33. A system as recited in claim 19, wherein the solid fluoride salt phase is included in an amount between about 0.1% and about 10% by weight of the multi-phase fluoride varnish composition.

34. A system as recited in claim 19, wherein the solid fluoride salt phase is included in an amount between about 1% and about 8% by weight of the multi-phase fluoride varnish composition.

35. A system as recited in claim 19, wherein the solid fluoride salt phase is included in an amount between about 3% and about 7% by weight of the multi-phase fluoride varnish composition.

36. A system as recited in claim 19, wherein the multi-phase fluoride varnish composition has a viscosity of at least about 1000 centipoise.

37. A system as recited in claim 19, wherein the multi-phase fluoride varnish composition has a viscosity between about 1300 centipoise and about 3500 centipoise.

38. A system as recited in claim 19, wherein the multi-phase fluoride varnish composition has a viscosity between about 1700 centipoise and about 2800 centipoise.

39. A system for mixing a multi-phase fluoride varnish composition preparatory to applying it to a person'"'"'s teeth, comprising:

a closed vessel comprising a hollow cylindrical container including an inner wall;

a quantity of a multi-phase fluoride varnish composition comprising a liquid hydrophobic adhesive phase and a solid fluoride salt phase that is insoluble in the liquid hydrophobic adhesive phase, the quantity of multi-phase fluoride varnish composition being contained within the closed vessel; and

a plug disposed within the hollow cylindrical container, the plug forming a seal against the inner wall, the plug being slidably disposed within the hollow cylindrical container so as to selectively provide turbulence to the multi-phase fluoride varnish composition within the closed vessel so as to substantially suspend the solid fluoride salt phase within the liquid hydrophobic adhesive phase.