3-HYDROXYPROPIONIC ACID AND OTHER ORGANIC COMPOUNDS

• US 20070184524A1
• Filed: 10/09/2006
• Published: 08/09/2007
• Est. Priority Date: 11/20/2000
• Status: Active Grant

• Current Assignee: Cargill Incorporated
• Original Assignee: Cargill Incorporated
• Inventors: Selifonova, Olga, Jessen, Holly, Selmer, Thorsten, Gokarn, Ravi, Buckel, Wolfgang, Gort, Steven
• Granted Patent: US 7,393,676 B2
• Time in Patent Office: Days
• US Class Current: 435/69.100
• CPC Class Codes: C12N 15/52 Genes encoding for enzymes or proenzymes
• CPC Class Codes: C12N 9/0004 Oxidoreductases (1.)
• CPC Class Codes: C12P 7/18 polyhydric
• CPC Class Codes: C12P 7/40 containing a carboxyl group including Peroxycarboxylic acids
• CPC Class Codes: C12P 7/42 Hydroxy-carboxylic acids
• CPC Class Codes: C12P 7/52 Propionic acid; Butyric acids
• CPC Class Codes: C12P 7/625 Polyesters of hydroxy carboxylic acids
• CPC Class Codes: Y02P 20/52 using catalysts, e.g. selective catalysts

Abstract

Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.

Claims

1-96. -96. (canceled)

97. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a sequence set forth in SEQ ID NO;

2, 10, 26, 35, 37, 39, 41, 141, 160, or 161;

(b) a sequence having at least 10 contiguous amino acid residues of a sequence set forth in SEQ ID NO;

2, 10, 26, 35, 37, 39, 41, 141, 160, or 161;

(c) a sequence that has at least 65 percent sequence identity with a sequence set forth in SEQ ID NO;

2, 10, 26, 35, 37, 39, 41, 141, 160, or 161;

(d) a sequence that has at least 65 percent sequence identity with at least 10 contiguous amino acid residues of a sequence set forth in SEQ ID NO;

2, 10, 26, 35, 37, 39, 41, 141, 160, or 161; and

(e) a sequence set forth in SEQ ID NO;

2, 10, 26, 35, 37, 39, 41, 141, 160, or 161 that contains at least one conservative substitution.