METHOD AND APPARATUS FOR HEAT OR ELECTROMAGNETIC CONTROL OF GENE EXPRESSION
First Claim
Patent Images
1. A system, comprising;
- a gene regulatory signal delivery device that emits a regulatory signal which directly or indirectly regulates a regulatable, field sensitive transcriptional control element; and
a controller coupled to the gene regulatory signal delivery device, the controller adapted to control the emission of the regulatory signal based on at least a sensed physiological parameter or a command, wherein the gene regulatory signal delivery device comprises an electromagnetic field generator adapted to emit an electromagnetic field having a predetermined frequency and strength and/or comprises a thermal radiator adapted to emit a thermal energy.
1 Assignment
0 Petitions
Accused Products
Abstract
A gene regulatory system controls biomarker, gene therapy or endogenous gene expression by emitting one or more forms of energy that regulate gene expression. The system may include a sensor to sense a signal indicative of a need for therapy. The regulation of gene expression is controlled based on the sensed signal and/or a user command. In one embodiment, the system delivers one or more electrical therapies in conjunction with controlling gene therapy or endogenous gene expression.
-
Citations
41 Claims
-
1. A system, comprising;
-
a gene regulatory signal delivery device that emits a regulatory signal which directly or indirectly regulates a regulatable, field sensitive transcriptional control element; and
a controller coupled to the gene regulatory signal delivery device, the controller adapted to control the emission of the regulatory signal based on at least a sensed physiological parameter or a command, wherein the gene regulatory signal delivery device comprises an electromagnetic field generator adapted to emit an electromagnetic field having a predetermined frequency and strength and/or comprises a thermal radiator adapted to emit a thermal energy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 40, 41)
-
-
11. A system, comprising;
-
an implantable medical device system including;
a sensor to sense a physiological parameter indicative of a predetermined condition;
an implant telemetry module to receive an external command;
a gene regulatory signal delivery device that emits a regulatory signal which directly or indirectly regulates a regulatable, field sensitive transcriptional control element; and
an implant controller coupled to the sensor and the implant telemetry module, the implant controller including a gene expression control module adapted to control the emission of the regulatory signal based on at least one of a sensed physiological parameter and the external command; and
an external system including an external telemetry module to transmit the external command to the implant telemetry module, wherein the gene regulatory signal delivery device comprises an electromagnetic field generator which emits an electromagnetic field having a predetermined frequency and strength and/or comprises a thermal radiator which emits a thermal energy. - View Dependent Claims (12, 13, 14, 15, 16, 17)
-
-
18. A method, comprising:
-
sensing a physiological parameter indicative of a predetermined condition;
detecting the predetermined condition from the sensed physiological parameter; and
delivering to mammalian cells a regulatory signal which directly or indirectly regulates expression from a regulatable, field sensitive transcriptional control element in the cells in response to at least the detection of the predetermined condition, wherein the regulatable, field sensitive transcriptional control element is operably linked to an open reading frame to form an expression cassette or the regulatable, field sensitive transcriptional control element is operably linked to an open reading frame in an endogenous gene, wherein thermal energy and/or electromagnetic energy of a predetermined frequency and strength is delivered. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 38, 39)
-
Specification