High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair
First Claim
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1. An implantable device comprising a reticulated resiliently-compressible elastomeric matrix comprising a plurality of pores, wherein the implantable device further comprises a reinforcement in at least one dimension.
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Abstract
This invention relates to reticulated elastomeric matrices, their manufacture, their post-processing, such as their reinforcement, compressive molding or annealing, and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for surgical devices, tissue augmentation, tissue repair, therapeutic, nutritional, or other useful purposes.
264 Citations
101 Claims
- 1. An implantable device comprising a reticulated resiliently-compressible elastomeric matrix comprising a plurality of pores, wherein the implantable device further comprises a reinforcement in at least one dimension.
- 28. An implantable device comprising a reticulated resiliently-compressible elastomeric matrix comprising a plurality of pores, wherein the implantable device is compressive molded after it is reticulated.
- 60. An implantable device comprising a reticulated resiliently-compressible elastomeric matrix comprising a plurality of pores, wherein the implantable device is annealed after it is reticulated.
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76. A polymerization process for preparing an elastomeric matrix, the process comprising admixing:
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a) 100 parts by weight of a polyol component, b) from about 10 to about 90 parts by weight of an isocyanate component, c) from about 0.5 to about 6.0 parts by weight of a blowing agent, d) optionally, from about 0.05 to about 8.0 parts by weight of a cross-linking agent, e) optionally, from about 0.05 to about 8.0 parts by weight of a chain extender, f) optionally, from about 0.05 to about 3.0 parts by weight of at least one catalyst, g) optionally, from about 0.1 to about 8.0 parts by weight of at least one cell opener, h) from about 0.1 to about 8.0 parts by weight of a surfactant, and i) optionally, up to about 15 parts by weight of a viscosity modifier;
to provide the elastomeric matrix. - View Dependent Claims (77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96)
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97. A process for preparing an at least partially reticulated elastomeric matrix, the process comprising:
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1) admixing;
a) 100 parts by weight of an elastomeric material, b) optionally, from about 2 to about 70 parts by weight of a more hydrophilic polymeric material, c) optionally, from about 0.1 to about 20 parts by weight of a cross-linking agent, and d) optionally, from about 1 to about 20 parts by weight of a blowing agent to form a mixture;
2) exposing the mixture to microwave irradiation at a frequency of from about 2.2 GHz to about 6.0 GHz, optionally while also heating the mixture to a temperature of from about 70°
C., to about 225°
C.;
to provide the at least partially reticulated elastomeric matrix. - View Dependent Claims (98, 99, 100, 101)
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Specification