Agents and devices for providing blood clotting functions to wounds

• US 20070190110A1
• Filed: 02/06/2007
• Published: 08/16/2007
• Est. Priority Date: 02/10/2006
• Status: Abandoned Application

• Current Assignee: Cornelis Pameijer, Steven Jensen
• Original Assignee: Cornelis Pameijer, Steven Jensen
• Inventors: Pameijer, Cornelis, Jensen, Steven
• Application Number:
  US11/703,491
• Publication Number:
  US 20070190110A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61L 15/28 Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 2300/402 Anaestetics, analgesics, e.g. lidocaine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/412 Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 2300/418 Agents promoting blood coagulation, blood-clotting agents, embolising agents
• CPC Class Codes: A61L 2300/624 Nanocapsules
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 33/0076 Chemical modification of the substrate
• CPC Class Codes: C08B 15/04 Carboxycellulose, e.g. prepared by oxidation with nitrogen dioxide
• CPC Class Codes: C08L 1/04 Oxycellulose; Hydrocellulose , e.g. microcrystalline cellulose
• CPC Class Codes: D06M 10/00 Physical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents, or magnetic fields; Physical treatment combined with treatment with chemical compounds or elements
• CPC Class Codes: D06M 11/64 with nitrogen oxides; with oxyacids of nitrogen or their salts with pernitric acids or their salts D06M11/50

Abstract

Hemostatic agents and devices are made from oxidized cellulose fiber, the oxidized cellulose having a carboxylation content increased by the action of nitrogen dioxide on virgin cellulose fiber. A composition may be incorporated into the oxidized cellulose fiber to cause a pharmacological effect on a wound to which the hemostatic agents and devices are applied. When applied, the oxidized cellulose fiber causes blood emanating from the wound to clot. The oxidized cellulose fiber can either be resorbed into the wound or removed from the wound after healing. A hemostatic bandage includes a pad of unwoven oxidized cellulose fibers mounted on a substrate. Methods of arresting a flow of blood emanating from a wound using such devices are also disclosed. Methods of fabricating oxidized cellulose are also disclosed.

Claims

1. A hemostatic agent, comprising:

oxidized cellulose fiber having a carboxylation content increased relative to cellulose fiber that has not been oxidized, said increased carboxylation content being increased by the action of nitrogen dioxide on virgin cellulose fiber; and

wherein application of said oxidized cellulose fiber to a wound causes blood emanating from said wound to clot; and

wherein said oxidized cellulose fiber is resorbable into said wound.

2. The hemostatic agent of claim 1, wherein said nitrogen dioxide is generated by the catalytic reaction of at least one of manganese dioxide and manganese disulfide with nitric acid.

3. The hemostatic agent of claim 1, wherein said nitrogen dioxide is generated by the reaction of formaldehyde with nitric acid.

4. The hemostatic agent of claim 1, wherein said oxidized cellulose fiber comprises unwoven strands.

5. The hemostatic agent of claim 4, wherein said unwoven strands define a three-dimensional network.

6. The hemostatic agent of claim 1, wherein said virgin cellulose fiber is derived from cotton.

7. The hemostatic agent of claim 1, further comprising a composition incorporated into said oxidized cellulose fiber, said composition having a pharmaceutical effect on said wound.

8. The hemostatic agent of claim 7, wherein said composition is selected from the group consisting of antibiotics, bone stimulating drugs, corticosteroids, pain suppressing medications, anti-inflammatory drug, anti-viral drugs, anti-fungal drugs, homeopathic remedies, bone morphogenic proteins, osteoblast stimulating drugs, odontoblast stimulating drugs, compositions that accelerate healing, pain reducers, infection preventives, calcium hydroxide powder, mineral trioxide aggregate, bioactive glasses, and combinations of the foregoing.

9. The hemostatic agent of claim 7, wherein said composition incorporated into said oxidized cellulose fiber is imbedded into said oxidized cellulose fiber.

10. The hemostatic agent of claim 7, wherein said composition incorporated into said oxidized cellulose fiber is entrapped in a three-dimensional network of said oxidized cellulose fiber.

11. The hemostatic agent of claim 7, wherein said composition incorporated into said oxidized cellulose fiber is bound to nanoparticles which are incorporated into a three-dimensional network of said oxidized cellulose fiber.

12. The hemostatic agent of claim 1, wherein said carboxylation content is increased up to about 5% relative to said cellulose fiber that has not been oxidized.

13. The hemostatic agent of claim 1, wherein said action of said nitrogen dioxide on said virgin cellulose fiber minimizes a formation of fragments that produce aldehydes and ketone moieties.

14. The hemostatic agent of claim 1, wherein said nitrogen dioxide gas is produced by the action of formaldehyde on nitric acid.

15. A hemostatic device, comprising:

a pellet of unwoven oxidized cellulose fiber implantable into a wound, said oxidized cellulose fiber having a carboxylation content increased by the action of nitrogen dioxide on virgin cellulose fiber; and

wherein upon implanting said pellet into said wound, said oxidized cellulose fiber causes blood emanating from said wound to clot.

16. The hemostatic device of claim 15, wherein said nitrogen dioxide is generated by the catalytic reaction of at least one of manganese dioxide and manganese disulfide with nitric acid.

17. The hemostatic device of claim 15, wherein said nitrogen dioxide is generated by the reaction of formaldehyde with nitric acid.

18. The hemostatic device of claim 15, further comprising a composition incorporated into said oxidized cellulose fiber for release into said wound, said composition having a pharmacological effect on said wound.

19. The hemostatic device of claim 18, wherein said composition is selected from the group consisting of antibiotics, bone stimulating drugs, corticosteroids, pain suppressing medications, anti-inflammatory drugs, anti-viral drugs, anti-fungal drugs, homeopathic remedies, bone morphogenic proteins, osteoblast stimulating drugs, odontoblast stimulating drugs, compositions that accelerate healing, pain reducers, infection preventives, calcium hydroxide powder, mineral trioxide aggregate, bioactive glasses, and combinations of the foregoing.

20. The hemostatic device of claim 18, wherein said release of said composition is a sustained release.

21. The hemostatic device of claim 18, wherein said composition is attached to said oxidized cellulose fibers.

22. The hemostatic device of claim 18, wherein said composition is entrapped in a three-dimensional network of said oxidized cellulose fibers.

23. The hemostatic device of claim 18, wherein said composition is bound to nanoparticles which are then incorporated into a three-dimensional network of said oxidized cellulose fibers.

24. The hemostatic device of claim 15, wherein said oxidized cellulose fiber is resorbable into the tissue of said wound.

25. The hemostatic device of claim 15, wherein said oxidized cellulose fiber is removable from the tissue of said wound subsequent to the clotting of said blood.

26. The hemostatic device of claim 15, wherein said action of said nitrogen dioxide on said virgin cellulose fiber minimizes a formation of fragments that produce aldehydes and ketone moieties.

27. A method of arresting a flow of blood emanating from a wound, said method comprising the steps of:

providing unwoven oxidized cellulose fiber, said oxidized cellulose fiber having a carboxylation content increased relative to cellulose fiber that has not been oxidized, said increased carboxylation content being increased by the action of nitrogen dioxide on virgin cellulose fiber;

applying said unwoven oxidized cellulose fiber to said wound, thereby causing hemostasis to result.

28. The method of claim 27, further comprising incorporating a composition into said unwoven oxidized cellulose fiber for release into said wound.

29. The method of claim 28, wherein said composition is selected from the group consisting of antibiotics, bone stimulating drugs, corticosteroids, pain suppressing medications, anti-inflammatory drugs, anti-viral drugs, anti-fungal drugs, homeopathic remedies, bone morphogenic proteins, osteoblast stimulating drugs, odontoblast stimulating drugs, compositions that accelerate healing, pain reducers, infection preventives, calcium hydroxide powder, mineral trioxide aggregate, bioactive glasses, and combinations of the foregoing.

30. The method of claim 28, further comprising allowing said unwoven oxidized cellulose fiber to be resorbed into the tissue of said wound.

31. The method of claim 28, further comprising removing said unwoven oxidized cellulose fiber from said wound.

32. A method of fabricating oxidized cellulose, said method comprising the steps of:

generating nitrogen dioxide gas in a first vessel;

piping said nitrogen dioxide gas to a second vessel containing cellulose fibers;

purging said second vessel with an excess amount of said nitrogen dioxide gas;

sealing said second vessel and allowing said second vessel to remain sealed for a predetermined period of time to increase a carboxylation content of said cellulose fibers; and

degassing said oxidized cellulose fibers.

33. The method of claim 32, further forming said oxidized cellulose fibers into pellets.

34. The method of claim 33, further comprising gamma-radiating said pellets.

35. The method of claim 32, further comprising incorporating a composition into said oxidized cellulose fibers, said composition having a pharmacological effect on a wound to which said oxidized cellulose fibers are applied.

36. A bandage applicable to a bleeding wound, said bandage comprising:

a substrate;

a pad of unwoven oxidized cellulose fibers mounted on said substrate, said oxidized cellulose fiber having a carboxylation content increased relative to cellulose fiber that has not been oxidized, said increased carboxylation content being increased by the action of nitrogen dioxide on virgin cellulose fiber;

wherein applying said pad to blood emanating from said wound causes said blood to clot and wherein said composition provides a pharmacological effect to said wound.

37. The bandage of claim 36, wherein said substrate includes holes to allow for the dissipation of moisture evaporating from a skin surface to which said bandage is applied.

38. The bandage of claim 36, further comprising a composition incorporated into said oxidized cellulose fibers of said pad for delivery to said wound.

39. The bandage of claim 38, wherein said composition is selected from the group consisting of antibiotics, bone stimulating drugs, corticosteroids, pain suppressing medications, anti-inflammatory drugs, anti-viral drugs, anti-fungal drugs, homeopathic remedies, bone morphogenic proteins, osteoblast stimulating drugs, odontoblast stimulating drugs, compositions that accelerate healing, pain reducers, infection preventives, calcium hydroxide powder, mineral trioxide aggregate, bioactive glasses, and combinations of the foregoing.