PHARMACEUTICAL COMPOSITIONS IN PARTICULATE FORM
First Claim
1. A method of preparing a pharmaceutical composition in the form of a powder within a chamber, the method comprising the steps of:
- a) atomizing a liquid formulation of a therapeutic or prophylactic agent to produce atomized droplets;
b) freezing the atomized droplets by introducing a cold medium into the chamber to form frozen particles; and
c) collecting and drying the frozen particles to produce a dry powder.
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Accused Products
Abstract
A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.
106 Citations
12 Claims
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1. A method of preparing a pharmaceutical composition in the form of a powder within a chamber, the method comprising the steps of:
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a) atomizing a liquid formulation of a therapeutic or prophylactic agent to produce atomized droplets;
b) freezing the atomized droplets by introducing a cold medium into the chamber to form frozen particles; and
c) collecting and drying the frozen particles to produce a dry powder. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of creating a powder within a chamber, the method comprising the steps of:
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providing a flow of liquid droplets containing a powder forming ingredient to form a flow of liquid droplets;
treating the liquid droplets with a flow of coolant inside the chamber to freeze the liquid droplets to form frozen particles prior to deposition;
depositing the frozen particles on a collector; and
after deposition of the frozen particles, drying the deposited frozen particles to form a dry powder. - View Dependent Claims (8, 9, 10, 11, 12)
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Specification