APPARATUS AND METHODS FOR ACOUSTIC DIAGNOSIS

• US 20070191740A1
• Filed: 12/29/2006
• Published: 08/16/2007
• Est. Priority Date: 01/20/2005
• Status: Abandoned Application

• Current Assignee: Abhilash Menon, Hemchandra Shertukde, Peter Beckmann, Raymond Mclaughlin, Rekha Shertukde
• Original Assignee: Abhilash Menon, Hemchandra Shertukde, Peter Beckmann, Raymond Mclaughlin, Rekha Shertukde
• Inventors: Shertukde, Rekha, Shertukde, Hemchandra, McLaughlin, Raymond, Beckmann, Peter, Menon, Abhilash
• Application Number:
  US11/618,510
• Publication Number:
  US 20070191740A1
• Time in Patent Office: Days
• US Class Current: 600/586
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: A61B 7/04 Electric stethoscopes microphones, acoustic transducers therefor H04R
• CPC Class Codes: A61B 8/56 Details of data transmission or power supply
• CPC Class Codes: A61B 8/565 involving data transmission via a network

Abstract

The apparatus and methods disclosed herein relate to diagnosis of disease through the detection of signals from portions of a body. The signals may be acoustic signals, which can be used to diagnose the presence, severity and/or location of occlusions in arteries, such as the coronary arteries. The signals may be detected through noninvasive methods such as, for example, passive reception. Such methods can avoid many of the problems associated with invasive angiogram and angioplasty procedures. The apparatus and methods described herein are not limited to use for diagnosing occlusions in the coronary arteries, but can be used for a wide variety of biomedical diagnosis in human and nonhuman animals.

Claims

1. A diagnostic method comprising:

sensing, by at least one sensor, acoustic energy emitted by blood flow in an artery of a patient;

producing, by said at least one sensor, at least one signal in response to said sensed acoustic energy;

validating said signal so as to determine whether at least a portion of said at least one signal is emitted by a heartbeat;

conditioning said at least one signal;

identifying a portion of said at least one conditioned signal;

performing a wavelet transform on said portion to produce a wavelet diagnostic parameter indicative of an attribute of said blood flow; and

outputting information relating to said attribute of said blood flow.

2. The diagnostic method of claim 1, wherein said artery is a coronary artery.

3. The diagnostic method of claim 1, wherein said sensed acoustic energy comprises frequency components in a range from about 300 Hz to about 2000 Hz.

4. The diagnostic method of claim 1, wherein said act of conditioning comprises at least one of digitizing, filtering, amplifying, and calculating a frequency representation of said at least one signal.

5. The diagnostic method of claim 1, wherein said wavelet transform uses a mother wavelet selected from the group consisting of a Haar, a Morlet, a Daubechies, a Mexican hat, a Hermitian, and an orthogonal mother wavelet.

6. The diagnostic method of claim 1, wherein said attribute of said blood flow relates to fluid turbulence in said artery.

7. The diagnostic method of claim 6, wherein said attribute is a Hurst coefficient.

8. The diagnostic method of claim 6, wherein said fluid turbulence is related to an occlusion of said artery.

9. The diagnostic method of claim 1, wherein said wavelet diagnostic parameter is related to a distribution of said acoustic energy with respect to a frequency scale parameter.

10. The diagnostic method of claim 1, wherein the portion of said at least one conditioned signal corresponds to at least a portion of a diastolic period of a heartbeat.

11. The diagnostic method of claim 1, wherein the act of identifying said portion further comprises detecting at least one heartbeat with a heartbeat sensor.

12. The diagnostic method of claim 11, wherein said heartbeat sensor comprises an electrocardiogram sensor or a pulse sensor.

13. The diagnostic method of claim 1, wherein said act of outputting further comprises displaying said information on a display device.

14. The diagnostic method of claim 1, further comprising diagnosing an abnormality of said artery from said wavelet diagnostic parameter.

15. The diagnostic method of claim 14, wherein said abnormality relates to an arterial stenosis or occlusion.

16. The diagnostic method of claim 14, wherein said act of diagnosing further comprises comparing said wavelet diagnostic parameter with a comparison diagnostic parameter.

17. The diagnostic method of claim 16, wherein said comparison diagnostic parameter is determined from an invasive procedure.

18. The diagnostic method of claim 14, further comprising determining a structure or an orientation of anatomical structures so as to determine an anatomical correspondence between said abnormality in said artery and the structure or the orientation of the anatomical structures.

19. The diagnostic method of claim 18, wherein said act of determining a structure or an orientation of anatomical structures further comprises using an anatomical sensor selected from the group consisting of an ultrasound device, a magnetic resonance imaging device, an X-ray device, an electrocardiogram device, an electroencephalogram device, and a computer aided tomography device.

20. The diagnostic method of claim 1, further comprising attaching said at least one sensor to said patient.