Radio frequency induced drug elution

• US 20070191816A1
• Filed: 02/13/2006
• Published: 08/16/2007
• Est. Priority Date: 02/13/2006
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: McMorrow, David, Behan, Niall, Motherwell, John, Malone, Anthony, Flanagan, Aiden, O'Brien, Barry
• Application Number:
  US11/353,800
• Publication Number:
  US 20070191816A1
• Time in Patent Office: Days
• US Class Current: 604/890.1
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2210/009 magnetic
• CPC Class Codes: A61F 2250/0001 Means for transferring electromagnetic energy to implants
• CPC Class Codes: A61F 2250/0035 differing in release or diffusion time
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61N 2/002 in combination with another treatment

Abstract

A medical device including at least one reservoir, adapted to contain a material, such as a therapeutic agent, and sealed by a cover. The reservoir is openable, so as to release the material, for example, by (i) disintegration of the cover, (ii) movement of the cover to an open position, and/or (iii) a change of composition or properties of the cover allowing the material to pass therethrough. The power required to open the reservoir is provied by a current induced in a coil associated with the medical device by a change in magnetic flux in the area of the medical device.

Claims

1. A medical device comprising:

at least one primary coil;

at least one reservoir adapted to contain a material, said at least one reservoir connected to or embedded in the at least one primary coil;

a cover configured to seal the at least one reservoir in a first state of the cover and to allow the material to exit the at least one reservoir in a second state of the cover; and

wherein said cover is configured such that it transitions between the first and second states when said coil is exposed to a magnetic flux.

2. The medical device of claim 1, wherein the cover in the second state is at least partially disintegrated.

3. The medical device of claim 1, wherein the cover in the second state completely covers the reservoir but is configured to allow the material to pass directly through it.

4. The medical device of claim 1, where the cover in the second state is shifted away from or towards the reservoir so as to unseal the reservoir.

5. The medical device of claim 1, wherein the cover in the second state has at least one smaller dimension than in the first state.

6. The medical device of claim 1, wherein the primary coil is connected such that a current induced in the primary coil by the magnetic flux passes through the cover.

7. The medical device of claim 1, wherein the medical device further comprises a substrate in which the at least one reservoir is formed.

8. The medical device of claim 1, wherein the medical device comprises a stent.

9. The medical device of claim 8, wherein the stent has a coil configuration and at least a portion of the coil configuration of the stent itself forms the primary coil.

10. The medical device of claim 8, wherein the primary coil is attached to a surface of the stent.

11. The medical device of claim 1, further comprising a second coil, wherein the at least one primary coil and the second coil are configured such that they each conduct a different level of current upon exposure to the same magnetic flux.

12. The medical device of claim 1, wherein said cover is a first cover and wherein said medical device further comprises a second reservoir covered by a second cover configured to seal the second reservoir in a first state and to allow material to exit the second reservoir in a second state, said first cover configured to transition between its first and second states when a first current passes through it, said second cover configured to transition between its first and second states when a second current different from the first current passes through it.

13. The medical device of claim 1, wherein the magnetic flux has a radio frequency.

14. The medical device of claim 1, further comprising at least one switch configured to control electrical communication between the cover and the primary coil.

15. The medical device of claim 14, further comprising a controller configured to control the at least one switch.

16. The medical device of claim 1, wherein the material is a therapeutic agent.

17. The medical device of claim 12, wherein the material is a first therapeutic agent and the second reservoir contains a second therapeutic agent.

18. The medical device of claim 1, wherein the at least one reservoir is formed in a polymer sleeve.

19. The medical device of claim 1, wherein the magnetic flux is time varying.