Activation of cardiac alpha receptors by spinal cord stimulation produces cardioprotection against ischemia, arrhythmias, and heart failure

• US 20070191895A1
• Filed: 11/21/2006
• Published: 08/16/2007
• Est. Priority Date: 04/20/2001
• Status: Abandoned Application

• Current Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Original Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Inventors: Armour, John, Foreman, Robert, Linderoth, Bengt, DeJongste, Michael, Ardell, Jeffrey
• Application Number:
  US11/603,841
• Publication Number:
  US 20070191895A1
• Time in Patent Office: Days
• US Class Current: 607/14
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension

Abstract

The present invention relates in general to methodologies for the treatment quenching preconditioning and communication between the peripheral cardiac nervous system and an electrical stimulus. In particular, the present invention utilizes spinal cord stimulation to alter and/or affect the peripheral cardiac nervous system and thereby protect cardiac function.

Claims

1. A method for protecting cardiac function and reducing cardiac malfunction, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

placing the stimulator adjacent a neural structure capable of carrying the electrical signal from the neural structure to the peripheral cardiac nervous system; and

activating the stimulator for a predetermined period of time to generate the electrical signal to protect cardiac function and reduce cardiac malfunction.

2. The method of claim 1, wherein the neural structure is a spinal cord.

3. The method of claim 1, wherein the neural structure is a portion of a thoracic spinal cord.

4. The method of claim 1, wherein the cardiac malfunction which is reduced is a ventricular malfunction.

5. The method of claim 4, wherein the ventricular malfunction is a ventricular arrhythmia.

6. The method of claim 1, wherein the cardiac malfunction which is reduced is an atrial malfunction.

7. The method of claim 6, wherein the atrial malfunction is an atrial arrhythmia.

8. The method of claim 6, wherein the atrial malfunction is an atrial fibrillation.

9. A method for treating an animal having a cardiac pathology by protecting cardiac function and reducing cardiac malfunction, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

placing the stimulator adjacent a neural structure capable of carrying the electrical signal from the neural structure to at least one of the peripheral cardiac nervous system and the heart; and

activating the stimulator for a predetermined period of time to generate the electrical signal to modulate at least one of the peripheral cardiac nervous system and the heart, and thereby protecting at least one of the peripheral cardiac nervous system and the heart to treat the heart.

10. The method of claim 9, wherein the neural structure is a spinal cord.

11. The method of claim 9, wherein the neural structure is a portion of a thoracic spinal cord.

12. The method of claim 9, wherein the cardiac malfunction which is reduced is a ventricular malfunction.

13. The method of claim 12, wherein the ventricular malfunction is a ventricular arrhythmia.

14. The method of claim 9, wherein the cardiac malfunction which is reduced is an atrial malfunction.

15. The method of claim 14, wherein the atrial malfunction is an atrial arrhythmia.

16. The method of claim 14, wherein the atrial malfunction is an atrial fibrillation.

17. A method for electrically communicating with at least one of a peripheral cardiac nervous system and a heart, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

placing the stimulator adjacent a neural structure capable of carrying the electrical signal from the neural structure to at least one of the peripheral cardiac nervous system and the heart; and

activating the stimulator for a predetermined period of time to generate the electrical signal to communicate with at least one of the peripheral cardiac nervous system and the heart.

18. The method of claim 17, wherein the neural structure is a spinal cord.

19. The method of claim 17, wherein the neural structure is a portion of a thoracic spinal cord.

20. A method of modulating electrical neuronal and humoral responses of at least one of a peripheral cardiac nervous system and a heart, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

placing the stimulator adjacent a neural structure capable of carrying the electrical signal from the neural structure to at least one of the peripheral cardiac nervous system and the heart; and

activating the stimulator for a predetermined period of time to thereby generate the electrical signal to modulate the electrical neuronal and humoral response of at least one of the peripheral cardiac nervous system and the heart.

21. The method of claim 20, wherein the neural structure is a spinal cord.

22. The method of claim 20, wherein the neural structure is a portion of a thoracic spinal cord.

23. A method of activating spinal cord neurons to induce a conformational change in a peripheral cardiac nervous system, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

placing the stimulator adjacent a spinal cord to carry the electrical signal from the spinal cord to a peripheral cardiac nervous system; and

activating the stimulator for a predetermined period of time to thereby generate the electrical signal to thereby activate spinal cord neurons in proximity of the stimulator so as to induce a conformational change in the peripheral cardiac nervous system.

24. A method for the prolonged activation of spinal cord neurons to induce a conformational change in a peripheral cardiac nervous system, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

placing the stimulator adjacent a spinal cord to carry the electrical signal from the spinal cord to a peripheral cardiac nervous system; and

activating the stimulator for a predetermined period of time to thereby generate the electrical signal to thereby activate spinal cord neurons in proximity of the stimulator so as to induce a conformational change in the peripheral cardiac nervous system wherein the activation effects persist for a period of time extending beyond the activation of the stimulator.

25. A method for transiently nullifying neuronal activation of a peripheral cardiac nervous system caused by cardiac malfunction, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

placing the stimulator adjacent a neural structure capable of carrying the electrical signal from the neural structure to the peripheral cardiac nervous system; and

activating the stimulator for a predetermined period of time to thereby generate the electrical signal to transiently nullify neuronal activation of a peripheral cardiac nervous system caused by cardiac malfunction.

26. The method of claim 25, wherein the neural structure is a spinal cord.

27. The method of claim 25, wherein the neural structure is a portion of a thoracic spinal cord.

28. A method for prolonged nullification of neuronal activation of a peripheral cardiac nervous system caused by cardiac malfunction, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

placing the stimulator adjacent a neural structure capable of carrying the electrical signal from the neural structure to the peripheral cardiac nervous system; and

activating the stimulator for a predetermined period of time to thereby generate the electrical signal to nullify the neuronal activation of the peripheral cardiac nervous system caused by cardiac malfunction for a prolonged period of time extending beyond stimulator activation.

29. The method of claim 28, wherein the neural structure is a spinal cord.

30. The method of claim 28, wherein the neural structure is a portion of a thoracic spinal cord.

31. A method for transiently modulating neuronal activation of a peripheral cardiac nervous system caused by cardiac malfunction, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

placing the stimulator adjacent a neural structure capable of carrying the electrical signal from the neural structure to the peripheral cardiac nervous system; and

activating the stimulator for a predetermined period of time to thereby generate the electrical signal to transiently modulate the neuronal activation of the peripheral cardiac nervous system caused by cardiac malfunction.

32. The method of claim 31, wherein the neural structure is a spinal cord.

33. The method of claim 31, wherein the neural structure is a portion of a thoracic spinal cord.

34. A method for prolonged modulation of neuronal activation of a peripheral cardiac nervous system caused by cardiac malfunction, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

placing the stimulator adjacent a neural structure capable of carrying the electrical signal from the neural structure to the peripheral cardiac nervous system; and

activating the stimulator for a predetermined period of time to thereby generate the electrical signal to modulate the neuronal activation of the peripheral cardiac nervous system caused by cardiac malfunction for a prolonged period of time extending beyond stimulator activation.

35. The method of claim 34, wherein the neural structure is a spinal cord.

36. The method of claim 34, wherein the neural structure is a portion of a thoracic spinal cord.

37. A method of inhibiting, treating or reducing a cardiac malfunction, comprising the steps of:

providing a stimulator capable of generating an electrical signal;

operatively associating the stimulator with a neural structure capable of stimulating a portion of the peripheral cardiac nervous system upon receiving the electrical signal from the stimulator; and

activating the stimulator thereby generating the electrical signal which stimulates the portion of the peripheral cardiac nervous system and inhibits, treats or reduces the cardiac malfunction.

38. The method of claim 37, wherein the neural structure is a spinal cord.

39. The method of claim 37, wherein the neural structure is a portion of a thoracic spinal cord.

40. The method of claim 37, wherein the cardiac malfunction which is reduced is an atrial malfunction.

41. The method of claim 40, wherein the atrial malfunction is an atrial arrhythmia.

42. The method of claim 40, wherein the atrial malfunction is an atrial fibrillation.

43. The method of claim 37, wherein the cardiac malfunction is a myocardial infarct induced by ventricular ischemia.

44. The method of claim 37, wherein the portion of the peripheral cardiac nervous system which is stimulated comprises adrenergic neurons.

45. The method of claim 44, wherein the stimulation of the adrenergic neurons acts via alpha-adrenoreceptors.

46. The method of claim 37, wherein the cardiac malfunction is an atrial fibrillation, atrial tachyarrhythmia, or bradycardia.

47. The method of claim 37, wherein the treatment of the cardiac malfunction is performed prior to conducting a subsequent procedure to treat the cardiac malfunction.