QUANTIFYING SYSTOLIC AND DIASTOLIC CARDIAC PERFORMANCE FROM DYNAMIC IMPEDANCE WAVEFORMS

• US 20070191901A1
• Filed: 04/25/2007
• Published: 08/16/2007
• Est. Priority Date: 06/04/2004
• Status: Abandoned Application

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Schecter, Stuart
• Application Number:
  US11/740,196
• Publication Number:
  US 20070191901A1
• Time in Patent Office: Days
• US Class Current: 607/17
• CPC Class Codes: A61B 5/0036 including treatment, e.g., using an implantable medical device, ablating, ventilating
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61B 5/7242 using integration
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

The present invention is related to implantable cardiac devices such as pacemakers and defibrillators that deliver cardiac resynchronization therapy (CRT), and to a method of optimizing acquisition of multi-vector impedance signals from electrodes present on implanted lead systems. Acquired impedance signals associated with dynamic intracardiac impedance are related to specific time frames of the cardiac cycle as to derive indices representative of systolic and diastolic cardiac performance. The impedance signals are further adjusted by non-dynamic or static impedance signals associated with pulmonary impedance as to derive composite indices representative of cardiac performance and pulmonary vascular congestion. The pulmonary impedance signals are preferably obtained during relative periods of apnea in a patient.

Claims

1. A method of controlling a cardiac resynchronization therapy (CRT) device comprising:

measuring a dynamic intrathoracic impedance from three or more electrode sites, wherein at least one electrode site is a non-intracardiac electrode site;

determining a control parameter associated with the dynamic intracardiac impedance data of a patient;

measuring a pulmonary impedance using the non-intracardiac electrode site and another of said three or more electrode sites;

reducing the control parameter based upon the thoracic impedance; and

setting an operational parameter of said CRT device based on a difference between said control parameter and a reference value.

2. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 1, wherein measuring the impedances comprises measuring the impedances from multiple vectors between the three or more electrode sites.

3. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 1, wherein the non-intracardiac electrode site is selected from a group consisting essentially of a device can of the CRT device, a pericardial lead, a left ventricle lateral coronary sinus lead, and a superior vena cava coil.

4. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 1, further comprising acquiring dynamic impedance data associated with both a systolic phase and a diastolic phase of the patient.

5. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 4, wherein the dynamic impedance data associated with the diastolic phase of the patient has an inverse relationship with the control parameter.

6. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 1, further comprising delivering an electrical stimulus during an absolute refractory phase of the patient based upon the operational parameter.

7. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 1, further comprising acquiring the dynamic intracardiac impedance data using a variable sampling rate.

8. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 1, wherein determining the control parameter is performed within said CRT device.

9. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 1, wherein reducing the control parameter is performed within said CRT device.

10. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 1, wherein measuring the dynamic intrathoracic impedance is performed over two or more cardiac cycles.

11. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 10, wherein the two or more cardiac cycles are consecutive cardiac cycles.

12. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 10, further comprising correlating the dynamic intrathoracic impedance with a concurrent respiratory cycle.

13. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 12, further comprising selecting a subset of the dynamic intrathoracic impedance correlating to a specific respiratory phase of the respiratory cycle.

14. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 13, wherein the specific respiratory phase is the end-expiratory phase.

15. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 13, wherein the specific respiratory phase is the end-inspiratory phase.

16. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 10, further comprising:

associating the dynamic intrathoracic impedance with a respiratory rate; and

selecting a subset of the dynamic intrathoracic impedance within a range of respiratory rates.

17. The method for controlling a cardiac resynchronization therapy (CRT) device as in claim 1, wherein the reference value is a prior control parameter determined at rest.

18. A cardiac resynchronization therapy (CRT) system comprising:

a cardiac resynchronization therapy (CRT) device configured to;

a) apply therapy to a patient based on a plurality of operational parameters;

b) detect a dynamic intrathoracic impedance of the patient, wherein the dynamic intrathoracic impedance comprises a dynamic intracardiac impedance component and a pulmonary impedance component; and

c) calculate a control parameter from the dynamic intracardiac impedance component and a pulmonary impedance component;

d) evaluate if said control parameter is acceptable; and

e) set said operational parameters based on said control parameter, if said control parameter is found acceptable.

19. The cardiac resynchronization therapy (CRT) system as in claim 18, wherein the control parameter has a negative relationship with the pulmonary impedance component.

20. The programming system as in claim 18, wherein the dynamic intrathoracic impedance of the patient further comprises a dynamic pulmonary impedance component.