Integrated dissolution processing and sample transfer system
First Claim
1. A system for dissolution testing, comprising:
- a plurality of dissolution vessels;
a dose carrier positioned above the plurality of dissolution vessels;
a first carousel removably disposed on the dose carrier, the first carousel configured to receive a tablet;
a second carousel removably disposed on the dose carrier, the second carousel configured to receive a basket, the basket configured to receive a capsule;
a drive head positioned above the dose carrier; and
a basket arbor and a mixing paddle removably attached to the drive head, wherein the basket arbor and the mixing paddle are interchangeable.
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Accused Products
Abstract
The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 μl to 1 ml from the dissolution vessels to wells of an external receptacle.
97 Citations
20 Claims
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1. A system for dissolution testing, comprising:
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a plurality of dissolution vessels;
a dose carrier positioned above the plurality of dissolution vessels;
a first carousel removably disposed on the dose carrier, the first carousel configured to receive a tablet;
a second carousel removably disposed on the dose carrier, the second carousel configured to receive a basket, the basket configured to receive a capsule;
a drive head positioned above the dose carrier; and
a basket arbor and a mixing paddle removably attached to the drive head, wherein the basket arbor and the mixing paddle are interchangeable. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for dissolution testing, the method comprising:
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providing a dissolution testing system comprising a dose carrier, a first dissolution vessel, a second dissolution vessel, a first carousel, and a second carousel;
loading a tablet into the first carousel;
loading a capsule into a basket, and loading the basket into the second carousel;
removably disposing the first and second carousels on the dose carrier;
introducing dissolution media into the first and second dissolution vessels;
submerging the tablet in the media in the first dissolution vessel; and
submerging the basket in the media in the second dissolution vessel. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A computer-usable medium including a program for dissolution processing and sample transfer, the program comprising:
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computer readable code for storing data representing the number of individual doses and types of dosage forms that have been loaded onto a dissolution processing and sample testing system;
computer readable code for introducing a volume of dissolution media into a dissolution vessel;
computer readable code for disposing an individual dose in the dissolution media within the dissolution vessel;
computer readable code for agitating the individual dose within the dissolution vessel;
computer readable code for removing an aliquot of sample solution from the dissolution vessel; and
computer readable code for delivering the sample solution aliquot to an external receptacle.
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Specification