Halosuccinimide biocide

• US 20070196359A1
• Filed: 02/23/2006
• Published: 08/23/2007
• Est. Priority Date: 02/23/2006
• Status: Abandoned Application

• Current Assignee: Minntech Corporation
• Original Assignee: Minntech Corporation
• Inventors: Stanley, Patricia, Walter, Bert, Matta, John
• Application Number:
  US11/360,067
• Publication Number:
  US 20070196359A1
• Time in Patent Office: Days
• US Class Current: 424/126
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 37/32 Cyclic imides of polybasic carboxylic acids or thio analogues thereof

Abstract

The present invention relates to biocides. More particularly, the present invention relates to a novel solution that is an effective high level disinfectant biocide. The present invention biocide includes a halide substituted N-succinimide in an aqueous solution in the pH range of 2-6. The biocide also includes N-succinimide as a stabilizer. In some embodiments the biocide may further include an anti-corrosive agent.

Claims

1. An aqueous biocide composition comprising

a) an N-halosuccinimide or derivative thereof;

b) a succinimide or a derivative thereof;

c) an anticorrosive agent; and

d) an aqueous carrier having a pH less than about 6.

2. The biocide composition of claim 1 wherein the N-halosuccinimide is a compound of the formula:

where;

X is Cl, Br or I;

R1, R2, R3 and R4, alone or together are hydrogen, CH3-, CH3-(CH2)n-, or an aromatic ring; and

n is 1-8.

3. The biocide composition of claim 2 wherein the N-halosuccinimide forms a compound of the formula:

where;

Y is C, SO or PO2;

the aromatic ring can be further substituted by R; and

R is a nitro, sulfo, or phospho group.

4. The biocide composition of claim 1 wherein the N-halosuccinimide is a compound of the formula:

where;

X is Cl, Br or I; and

R1, R2, R3 and R4 are hydrogen.

5. The biocide composition of claim 1 wherein the N-halosuccinimide is the N-chlorosuccinimide or the N-bromosuccinimide.

6. The biocide composition of claim 1 wherein the N-halosuccinimide comprises 0.1 to 3% of the composition.

7. The biocide composition of claim 1 wherein the succinimide or derivative thereof is a compound of the formula:

where;

X and R1-R4 are hydrogen, CH3-, CH3-(CH2)n-, or a substituted or unsubstituted aromatic ring; and

n is 1-8.

8. The biocide composition of claim 1 wherein the succinimide or derivative thereof is succinimide.

9. The biocide composition of claim 1 wherein the succinimide or derivative thereof comprises approximately 0.1-10% of the composition.

10. The biocide composition of claim 1 wherein the anticorrosive agent is effective to inhibit metal corrosion.

11. The biocide composition of claim 1 wherein the anticorrosive agent is selected from the group consisting of triazoles, alkylamines, and ethoxylates.

12. The biocide composition of claim 1 wherein the anticorrosive agent comprises 0.01-1% of the composition.

13. The biocide composition of claim 1 wherein the aqueous carrier has a pH in the range of about 2 to about 6.

14. The biocide composition of claim 1 further comprising additional additives.

15. The biocide composition of claim 1 further comprising one or more of the group consisting of surfactants, cosolvents, colorants, odorants, and buffers.

16. The biocide composition of claim 1 further comprising a buffer.

23. The method of claim 1 wherein succinimide is added to the aqueous composition.

17. A method of sterilizing a surface comprising

a) contacting a surface with a biocide composition for a time sufficient to totally kill 10⁶ microbial endospores, the composition including an N-halosuccinimide or derivative thereof, a succinimide or a derivative thereof, an anticorrosive agent, and an aqueous carrier having a pH less than about 6, and

b) rinsing the surface to remove residual biocide composition.

18. The method of claim 17 wherein contacting the surface comprises contacting the surface of a medical device.

19. The method of claim 17 wherein the contacting the surface comprises contacting the surface for about 30-600 seconds.

20. The method of claim 17 wherein contacting the surface comprises contacting the surface for about 15-240 minutes.

21. A method of stabilizing a N-halosuccinimide in an acidic aqueous composition comprising adding an effect amount of succinimide or derivative thereof to the aqueous composition.

22. The method of claim 21 wherein the effective amount of succinimide or a derivative thereof in a range of 0.1-10% of the composition.

24. A method of making an aqueous biocide composition comprising the steps of:

a) preparing an acetate buffer of approximately pH 3;

b) adding halosuccinimide whereby the halosuccinimide is about 1.5% of the composition;

c) adding succinimide to whereby the succinimide is about 9% of the composition; and

d) adding anti-corrosive agent whereby the anti-corrosive agent is about 0.5% of the concentration.