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Positive Selection Procedure for Optically Directed Selection of Cells

  • US 20070196815A1
  • Filed: 03/19/2007
  • Published: 08/23/2007
  • Est. Priority Date: 08/02/2000
  • Status: Abandoned Application
First Claim
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1. A method for positive cell selection comprising:

  • providing a substrate with multiple locations;

    immobilizing one or more cells comprising a photosensitive repair system and capable of exhibiting an imagable property when excited, indicating a desirable cell, either onto or within said substrate;

    detecting the desirable cells by applying an excitation light source to the substrate to excite the imagable property of at least one of the one or more cells;

    recording locations containing the desirable cells and locations not containing the desirable cells;

    generating a repair image from the locations of the desirable cells;

    applying a lethal light source to the substrate wherein the lethal light source is lethal to the cells, if the cells are not exposed to a repair light source capable of activating the photosensitive repair systems of the cells scanned; and

    projecting a repair light source according to the repair image onto the substrate, the projection having light and dark portions wherein the light portions are capable of activating the photosensitive repair systems of the cells projected upon.

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