METHOD AND DEVICE FOR ANALYTE MEASUREMENT
First Claim
1. An apparatus for measuring concentration of a target analyte in a sample containing a plurality of alternate analytes, the apparatus comprising:
- a light generation module adapted to generate a plurality of light wavelength bands each band of a narrow wavelength;
the light generation module adapted to switch each of the plurality of light wavelength bands between two or more predetermined intensities;
a light combination module adapted to combine the plurality of light bands into a narrow beam;
a focusing module adapted to direct the narrow beam onto the sample;
a light detection module adapted to detect light from the apparatus having passed through or reflected from the sample;
a measurement module adapted to measure the intensity of the light which has passed through or reflected from the sample; and
a determination module adapted to determine the concentration of the target analyte based on the intensity of the light which has passed through or reflected from the sample.
1 Assignment
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Accused Products
Abstract
A device for non-invasively measuring concentration of one or more analytes in a living subject or a biological sample, wherein the device includes several light sources, a system for controlling the timing and intensity of the light source outputs, a system for passing the light through the subject or sample, a system for measuring the amount of light transmitted, and a system for relating the measurement to the concentration of the analyte in question. The light sources are narrow band sources at different wavelengths, and are capable of being rapidly switched between two levels of intensity. The actual number of light sources required and the wavelengths of the sources are dependent upon the specific analyte being measured.
51 Citations
63 Claims
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1. An apparatus for measuring concentration of a target analyte in a sample containing a plurality of alternate analytes, the apparatus comprising:
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a light generation module adapted to generate a plurality of light wavelength bands each band of a narrow wavelength; the light generation module adapted to switch each of the plurality of light wavelength bands between two or more predetermined intensities; a light combination module adapted to combine the plurality of light bands into a narrow beam; a focusing module adapted to direct the narrow beam onto the sample; a light detection module adapted to detect light from the apparatus having passed through or reflected from the sample; a measurement module adapted to measure the intensity of the light which has passed through or reflected from the sample; and a determination module adapted to determine the concentration of the target analyte based on the intensity of the light which has passed through or reflected from the sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 33, 34, 35, 36, 37)
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17. An apparatus for measuring concentration of a target analyte in a sample containing a plurality of alternate analytes, the apparatus comprising:
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a light generation module adapted to generate a plurality of light wavelength bands each band of a narrow wavelength; wherein the light generation module further comprises a plurality of light sources, each of the plurality of light sources adapted to generate one or more of the plurality of light bands; wherein the light generation module is further adapted to monitor the internal temperature of at least one of the plurality of light sources using at least one of;
(1) a thermocouple;
(2) a thermistor; and
(3) a voltage drop measurement apparatus adapted to measure voltage drop across a semiconductor junction of the at least one of the plurality of light sources; andwherein the light generation module is further adapted to calibrate output of the plurality of light sources according to their internal temperatures. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An apparatus for measuring concentration of a target analyte in a sample containing a plurality of alternate analytes, the apparatus comprising:
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a light generation module adapted to generate a plurality of light wavelength bands each band of a narrow wavelength; a light combination module adapted to combine the plurality of light bands into a narrow beam; a focusing module adapted to direct the narrow beam onto the sample; a light detection module adapted to detect light from the apparatus having passed through or reflected from the sample; a measurement module adapted to measure the intensity of the light which has passed through or reflected from the sample; a determination module adapted to determine the concentration of the target analyte based on the intensity of the light which has passed through or reflected from the sample; wherein the light generation module further comprises a plurality of light sources, each of the plurality of light sources adapted to generate one or more of the plurality of light bands; wherein one or more of the plurality of light sources generating a single light band are duplicated at different spatial locations within the light generation module; and wherein the determination module is further adapted to use the differences in light transmission between duplicated sources to correct measurements of the target analyte concentration. - View Dependent Claims (28, 29, 30, 31, 32)
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38. A method of measuring concentration of a target analyte in a sample containing a plurality of alternate analytes, the method comprising:
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generating a plurality of independently controlled light wavelength bands; switching the plurality of light bands between two or more predetermined waveband intensity distributions; combining the plurality of light bands into a narrow light beam; directing the narrow light beam onto the sample; detecting the light beam having passed through or reflected from the sample; measuring the intensity of the light beam which has passed through or reflected from the sample; determining the concentration of the target analyte based on the difference in the net intensity between two predetermined waveband intensity distributions in the light beam which has passed through or reflected from the sample; and correcting the analyte concentration measurement using light transmission data from one or more light sources which have been duplicated at different locations in space. - View Dependent Claims (39)
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40. A method of measuring concentration of a target analyte in a sample containing a plurality of alternate analytes, the method comprising:
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generating a plurality of light wavelength bands; switching each of the plurality of light wavelength bands between two or more predetermined wavelength intensity distributions; combining the plurality of light bands into a narrow beam; directing the narrow beam onto the sample; detecting the narrow beam having passed through or reflected from the sample; measuring the intensity of the narrow beam which has passed through or reflected from the sample; and determining the concentration of the target analyte based on the intensity of the narrow beam which has passed through or reflected from the sample. - View Dependent Claims (41, 42, 43, 44, 45, 46, 47, 48, 49)
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50. A method of measuring concentration of a target analyte in a sample containing a plurality of alternate analytes, the method comprising:
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generating a plurality of light wavelength bands each band of a narrow wavelength; switching each of the plurality of light wavelength bands between two or more predetermined wavelength intensity distributions; wherein generating a plurality of light wavelength bands further comprises generating a plurality of light bands using a plurality of light sources; and further comprising monitoring the internal temperature of at least one of the plurality of light sources using at least one of;
(1) a thermocouple;
(2) a thermistor; and
(3) a voltage drop measurement apparatus adapted to measure voltage drop across a semiconductor junction of the at least one of the plurality of light sources; and
calibrating output of the plurality of light sources according to their internal temperatures. - View Dependent Claims (51, 52, 53, 54, 55, 56)
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57. A method of measuring concentration of a target analyte in a sample containing a plurality of alternate analytes, the method comprising:
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generating a plurality of light wavelength bands; combining the plurality of light bands into a narrow beam; directing the narrow beam onto the sample; detecting the narrow beam having passed through or reflected from the sample; measuring the intensity of the narrow beam which has passed through or reflected from the sample; determining the concentration of the target analyte based on the intensity of the narrow beam which has passed through or reflected from the sample; wherein generating a plurality of light bands further comprises generating a plurality of light bands using a plurality of light sources, each of the plurality of light sources adapted to generate one or more of the plurality of light bands; wherein one or more of the plurality of light sources generating a single light band are duplicated at different spatial locations within the light generation module; and wherein determining the concentration of the target analyte further comprises using the differences in light transmission between duplicated sources to correct measurements of the target analyte concentration. - View Dependent Claims (58, 59, 60, 61, 62, 63)
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Specification