Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects
First Claim
1. A method for treating an osteochondral defect or a chondral defect in a subject, comprising implanting a composite in a site of the osteochondral or chondral defect, the composite including:
- a) a hyaluronic acid derivative, wherein carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or O-acyl isourea, or both N-acylurea and O-acyl isourea; and
b) at least one member of the group consisting of a cell, a cellular growth factor and a cellular differentiation factor, which is impregnated in, or coupled to, the hyaluronic acid derivative.
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Abstract
A method for treating an osteochondral defect or a chondral defect in a subject includes implanting a composite in a site of the osteochondral or chondral defect. The composite includes a hyaluronic acid derivative; and at least one member of the group consisting of a cell, a cellular growth factor and a cellular differentiation factor, which is impregnated in, or coupled to, the hyaluronic acid derivative. In one embodiment, carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or O-acyl isourea, or both N-acylurea and O-acyl isourea. In another embodiment, the hyaluronic acid derivative is prepared by reacting an uncrosslinked hyaluronic acid with a biscarbodimide in the presence of a pH buffer in a range of between about 4 and about 8. The composite can be used for regenerating or stimulating regeneration of meniscal tissues in a subject in need thereof.
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Citations
28 Claims
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1. A method for treating an osteochondral defect or a chondral defect in a subject, comprising implanting a composite in a site of the osteochondral or chondral defect, the composite including:
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a) a hyaluronic acid derivative, wherein carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or O-acyl isourea, or both N-acylurea and O-acyl isourea; and
b) at least one member of the group consisting of a cell, a cellular growth factor and a cellular differentiation factor, which is impregnated in, or coupled to, the hyaluronic acid derivative. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for regenerating or promoting regeneration of cartilage and/or bone in an osteochondral or chondral defect in a subject, comprising:
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a) forming a scaffold that includes a hyaluronic acid derivative and a support, wherein carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or O-acyl isourea, or both N-acylurea and O-acyl isourea;
b) impregnating in, or coupling to, the scaffold at least one member of the group consisting of a cell, and a cellular growth and differentiation factor in the scaffold; and
c) implanting the scaffold that is impregnated or coupled with said at least one member of the group consisting of a cell, and a cellular growth and differentiation factor at a site of the osteochondral or chondral defect of the subject, thereby providing a mechanism for delivery of the cell, cellular growth factor or cellular differentiation factor to the site of the osteochondral or chondral defect to regenerate or promote regeneration of cartilage and bone in the osteochondral or chondral defect. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification