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Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects

  • US 20070202084A1
  • Filed: 12/13/2006
  • Published: 08/30/2007
  • Est. Priority Date: 12/14/2005
  • Status: Abandoned Application
First Claim
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1. A method for treating an osteochondral defect or a chondral defect in a subject, comprising implanting a composite in a site of the osteochondral or chondral defect, the composite including:

  • a) a hyaluronic acid derivative, wherein carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or O-acyl isourea, or both N-acylurea and O-acyl isourea; and

    b) at least one member of the group consisting of a cell, a cellular growth factor and a cellular differentiation factor, which is impregnated in, or coupled to, the hyaluronic acid derivative.

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