Promac signature application
First Claim
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1. A method for diagnosing a neurodegenerative disorder in a subject comprising detecting the expression of a panel of ProMac signature genes in a biological sample of the subject, wherein a higher than normal level of expression of the panel of ProMac signature genes is indicative of a neurodegenerative disorder in the subject.
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Abstract
The present invention is directed to ProMac signature genes and methods and kits for using the ProMac signature genes for diagnostic, prognostic, or monitoring ProMac associated diseases.
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46 Claims
- 1. A method for diagnosing a neurodegenerative disorder in a subject comprising detecting the expression of a panel of ProMac signature genes in a biological sample of the subject, wherein a higher than normal level of expression of the panel of ProMac signature genes is indicative of a neurodegenerative disorder in the subject.
- 17. A kit comprising one or more probes useful for detecting the expression of a panel of ProMac signature genes in a sample from a subject.
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29. A method for distinguishing a first neurodegenerative disorder from a second neurodegenerative disorder comprising
evaluating the expression of a panel of ProMac secondary signature genesassociated with the first and the second neurodegenerative disorder in a biological sample from the subject, and correlating the expression of the panel of ProMac secondary signature genes with the determination of the first neurodegenerative disorder or the second neurodegenerative disorder, wherein the first neurodegenerative disorder is cerebral neuron degeneration and the second neurodegenerative disorder is motor neuron degeneration.
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35. A method for monitoring the treatment of a neurodegenerative disease in a subject comprising monitoring the expression of a panel of ProMac signature genes in a biological sample from the subject, wherein the level of expression of the panel of ProMac signature genes positively correlates with the progress of the neurodegenerative disease in the subject.
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36. A method for monitoring the treatment of a ProMac associated disease in a subject comprising monitoring the expression of a panel of ProMac signature genes in a biological sample from the subject, wherein the level of expression of the panel of ProMac signature genes positively correlates with the progress of the ProMac associated disease in the subject.
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37. A method for monitoring the level of disease associated macrophages in a subject comprising monitoring the expression of a panel of ProMac signature genes in a biological sample from the subject, wherein the level of expression of the panel of ProMac signature genes positively correlates with the level of disease associated macrophages in the subject.
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38. A method for evaluating an agent comprising contacting the agent with a macrophage and evaluating the expression of a panel of ProMac signature genes in the presence and absence of the agent, wherein a change caused by the agent is indicative of the agent as a modulator of ProMac.
- 39. A method for providing a prognosis of a ProMac associated disease in a subject comprising detecting the expression of a panel of ProMac signature genes in a biological sample from the subject, wherein the expression of the panel of ProMac signature genes is negatively associated with a positive outcome of the ProMac associated disease.
- 44. A method for providing a prognosis of a ProMac associated disease in a subject comprising detecting the expression of a panel of ProMac secondary signature genes in a biological sample from the subject, wherein the expression of the panel of ProMac secondary signature genes is negatively associated with a positive outcome of the ProMac associated disease.
Specification