Assessing risk of cerebrovascular thrombosis by measuring C4d on platelets
First Claim
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1. A method for assessing risk of cerebrovascular thrombosis in an individual comprising the steps of:
- (a) determining the platelet surface level of a complement pathway component C4d in the individual, and (b) comparing the level of C4d of the individual with a standard control, wherein an increase in the level of C4d from the standard control indicates an increased risk of cerebrovascular thrombosis in the individual.
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Abstract
This invention provides for a convenient, economical, and sensitive test for assessing the risk of a person suffering from a thrombotic stroke. More specifically, it has been determined that persons at risk for cerebrovascular thrombosis have an elevated deposition of C4d on their platelets.
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Citations
14 Claims
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1. A method for assessing risk of cerebrovascular thrombosis in an individual comprising the steps of:
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(a) determining the platelet surface level of a complement pathway component C4d in the individual, and (b) comparing the level of C4d of the individual with a standard control, wherein an increase in the level of C4d from the standard control indicates an increased risk of cerebrovascular thrombosis in the individual. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for diagnosing or monitoring cerebrovascular thrombosis in an individual comprising the steps of:
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(a) determining the platelet surface level of a complement pathway component C4d in the individual, and (b) comparing the level of C4d of the individual with a standard control, wherein an increase in the level of C4d from the standard control indicates the presence of cerebrovascular thrombosis or a worsening of cerebrovascular thrombosis in the individual. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A computer readable medium for predicting, diagnosing, or monitoring cerebrovascular thrombosis in an individual, the computer readable medium comprising:
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(a) code for receiving data corresponding to a level of the complement pathway component C4d on the surface of platelets from an individual;
(b) code for retrieving a standard control; and
(c) code for comparing the data in (a) with the standard control in (b).
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Specification