Devices And Methods For Measuring Clinically Relevant Analytes In Fluids
First Claim
1. A device for measuring a level of a clinically relevant analyte in a fluid, including:
- a flow path for conducting said fluid through the device;
a predetermined amount of said analyte arranged on said flow path such that the analyte mixes with fluid that passes it to form a calibration sample of the fluid;
detector means arranged on said flow path for detecting respective analyte levels in an unadulterated sample of the fluid and in the calibration sample.
3 Assignments
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Accused Products
Abstract
Methods and devices for the measurement of clinically relevant analytes in fluids are provided. The devices and methods are particularly relevant for detection of glucose in blood and allow internal calibration of measurements. One device includes a flow path for conducting the fluid through the device; a predetermined amount of the analyte arranged on the flow path such that the analyte mixes with fluid that passes it to form a calibration sample of the fluid and detector means arranged on the flow path for detecting respective analyte levels in an unadulterated sample of the fluid and in the calibration sample. Another device provides a predetermined amount of a calibration analyte of a different species to the clinically relevant analyte arranged on the flow path, and first and second detector means for detecting the levels of the clinically relevant analyte and the calibration analyte. One method includes the steps of mixing a sample of the fluid with a known amount of the analyte to form a calibration sample, measuring the analyte levels in both the calibration sample and the unadulterated sample and adjusting the level measured in the unadulterated sample using the level measured in the calibration sample. Another method mixes a known amount of a calibration analyte of a different species to the clinically relevant analyte with the fluid; measures the levels of the clinically relevant analyte and the calibration analyte and adjusts the measured level of the clinically relevant analyte accordingly.
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Citations
41 Claims
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1. A device for measuring a level of a clinically relevant analyte in a fluid, including:
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a flow path for conducting said fluid through the device;
a predetermined amount of said analyte arranged on said flow path such that the analyte mixes with fluid that passes it to form a calibration sample of the fluid;
detector means arranged on said flow path for detecting respective analyte levels in an unadulterated sample of the fluid and in the calibration sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 20, 21, 22, 23, 24)
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15. A device for measuring a level of a clinically relevant analyte in a fluid, the device including:
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a flow path for conducting said fluid through the device;
a predetermined amount of a calibration analyte arranged on said flow path such that the calibration analyte mixes with fluid that passes it to form a calibration sample, the calibration analyte being a different species to said clinically relevant analyte;
first detector means arranged on said flow path for detecting a level of said clinically relevant analyte in the calibration sample; and
second detector means arranged on said flow path for detecting a level of said calibration analyte in the calibration sample. - View Dependent Claims (16, 17, 18, 19)
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25. A method for testing, in a portable device, levels of clinically relevant analytes in a fluid including the steps of:
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mixing a sample of the fluid with a known amount of said analyte to form a calibration sample;
measuring the analyte level in an unadulterated sample of the fluid;
measuring the analyte level in said calibration sample; and
adjusting the analyte level measured in said unadulterated sample using the analyte level measured in said calibration sample. - View Dependent Claims (26, 27, 28, 29, 30, 31, 35, 36, 37, 38, 39, 40, 41)
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32. A method for testing, in a portable device, levels of a clinically relevant analyte in a fluid, including the steps of:
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mixing a known amount of a calibration analyte into a sample of said fluid, the calibration analyte being a different species to said clinically relevant analyte;
measuring the level of said clinically relevant analyte in said sample;
measuring the level of said calibration analyte in said sample;
adjusting the measured level of said clinically relevant analyte using the measured level of said calibration analyte. - View Dependent Claims (33, 34)
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Specification